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SIPA1L1 SIPA1L1 EGF EGF RALA RALA FGF9 FGF9 EPHA2 EPHA2 PIK3R3 PIK3R3 PDGFA PDGFA SIPA1 SIPA1 LPAR5 LPAR5 EFNA5 EFNA5 IGF1 IGF1 ADCY9 ADCY9 CRKL CRKL PFN3 PFN3 THBS1 THBS1 FPR1 FPR1 PLCB1 PLCB1 CALML5 CALML5 MAGI1 MAGI1 PLCB4 PLCB4 RAPGEF6 RAPGEF6 MAPK1 MAPK1 CALML3 CALML3 P2RY1 P2RY1 FGF19 FGF19 VAV3 VAV3 EFNA4 EFNA4 TLN1 TLN1 ADCY7 ADCY7 GRIN2B GRIN2B EFNA1 EFNA1 KRIT1 KRIT1 IGF1R IGF1R ANGPT4 ANGPT4 PARD6G PARD6G PIK3R2 PIK3R2 PIK3CA PIK3CA GNAQ GNAQ ADORA2B ADORA2B MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS MAP2K2 MAP2K2 RGL4 RGL4 MAPK12 MAPK12 PDGFB PDGFB DRD2 DRD2 CRK CRK RASSF5 RASSF5 PRKD3 PRKD3 RAPGEF2 RAPGEF2 GNAI1 GNAI1 ITGB3 ITGB3 F2RL3 F2RL3 ADCY6 ADCY6 PGF PGF RAC2 RAC2 GRIN1 GRIN1 CDC42 CDC42 FGF20 FGF20 FGFR1 FGFR1 FGF5 FGF5 KITLG KITLG FGF22 FGF22 RHOA RHOA PRKCA PRKCA PIK3CB PIK3CB GNAI2 GNAI2 ANGPT2 ANGPT2 PDGFRA PDGFRA ADORA2A ADORA2A RGS14 RGS14 RAC1 RAC1 KIT KIT GNAS GNAS PLCE1 PLCE1 BCAR1 BCAR1 EVL EVL FLT1 FLT1 GNAS-2 GNAS-2 CALML4 CALML4 LOC100989777 LOC100989777 FGF21 FGF21 TIAM1 TIAM1 RRAS RRAS PDGFD PDGFD FGF16 FGF16 FGF23 FGF23 RASGRP3 RASGRP3 PRKCI PRKCI FGFR3 FGFR3 TEK TEK GRIN2A GRIN2A PRKCB PRKCB FGFR2 FGFR2 F2R F2R HGF HGF ADCY2 ADCY2 RAF1 RAF1 CTNNB1 CTNNB1 EFNA3 EFNA3 AKT3 AKT3 LCP2 LCP2 TLN2 TLN2 RALB RALB BRAF BRAF MAPK11 MAPK11 ADCY5 ADCY5 MRAS MRAS VAV1 VAV1 PRKD1 PRKD1 ID1 ID1 FGFR4 FGFR4 VASP VASP FGF7 FGF7 ITGAM ITGAM ACTG1 ACTG1 MAP2K6 MAP2K6 ADCY8 ADCY8 PDGFRB PDGFRB VAV2 VAV2 CALM3 CALM3 MAPK13 MAPK13 PARD6A PARD6A NRAS NRAS MET MET RAPGEF4 RAPGEF4 MAGI2 MAGI2 GNAI3 GNAI3 PARD6B PARD6B ADCY3 ADCY3 ARAP3 ARAP3 ADCY4 ADCY4 ITGB1 ITGB1 PARD3 PARD3 PFN4 PFN4 PDGFC PDGFC FGF10 FGF10 SKAP1 SKAP1 SIPA1L2 SIPA1L2 ADCY1 ADCY1 LPAR1 LPAR1 RASGRP2 RASGRP2 FYB FYB NGFR NGFR ITGA2B ITGA2B NGF NGF RAP1B RAP1B FGF8 FGF8 APBB1IP APBB1IP PLCB2 PLCB2 CALML6 CALML6 RAP1A RAP1A AKT1 AKT1 RAPGEF1 RAPGEF1 PLCB3 PLCB3 FGF6 FGF6 SRC SRC FGF1 FGF1 ITGAL ITGAL DOCK4 DOCK4 PFN1 PFN1 RAPGEF5 RAPGEF5 RALGDS RALGDS VEGFD VEGFD GNAO1 GNAO1 CSF1R CSF1R FGF2 FGF2 FGF3 FGF3 MAPK14 MAPK14 FARP2 FARP2 LPAR3 LPAR3 PIK3R1 PIK3R1 SIPA1L3 SIPA1L3 FLT4 FLT4 CTNND1 CTNND1 PRKCZ PRKCZ CSF1 CSF1 KDR KDR RAPGEF3 RAPGEF3 VEGFC VEGFC LPAR2 LPAR2 FGF18 FGF18 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIPA1L1Signal induced proliferation associated 1 like 1. (1804 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RALARAS like proto-oncogene A. (206 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EPHA2EPH receptor A2. (976 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
SIPA1Signal-induced proliferation-associated 1. (1045 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (188 aa)
IGF1IlGF domain-containing protein. (196 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
THBS1Thrombospondin 1. (1173 aa)
FPR1Formyl peptide receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
MAGI1Uncharacterized protein. (1129 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
RAPGEF6Uncharacterized protein. (1609 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
EFNA4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (201 aa)
TLN1Talin 1. (2558 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
KRIT1Uncharacterized protein. (736 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
ANGPT4Angiopoietin 4. (503 aa)
PARD6GPar-6 family cell polarity regulator gamma. (333 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
GNAQG protein subunit alpha q. (313 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (357 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
RGL4Ras-GEF domain-containing protein. (588 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
RASSF5Ras association domain family member 5. (418 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1611 aa)
GNAI1G protein subunit alpha i1. (323 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
RAC2Rac family small GTPase 2. (192 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
CDC42Uncharacterized protein. (191 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
RHOAUncharacterized protein. (206 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ANGPT2Angiopoietin 2. (495 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
RGS14Regulator of G protein signaling 14. (567 aa)
RAC1Uncharacterized protein. (224 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
GNASGNAS complex locus. (1043 aa)
PLCE1Phosphoinositide phospholipase C. (2276 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
EVLEnah/Vasp-like. (423 aa)
FLT1Uncharacterized protein. (736 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
LOC100989777Uncharacterized protein. (191 aa)
FGF21Uncharacterized protein. (147 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
RRASRAS related. (176 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
FGFR3Fibroblast growth factor receptor. (780 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CTNNB1Catenin beta 1. (781 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
TLN2Talin 2. (2544 aa)
RALBRAS like proto-oncogene B. (254 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
ACTG1Actin gamma 1. (375 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (923 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1256 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1537 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PARD3Par-3 family cell polarity regulator. (1316 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SKAP1Src kinase associated phosphoprotein 1. (359 aa)
SIPA1L2Signal induced proliferation associated 1 like 2. (1722 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
RASGRP2RAS guanyl releasing protein 2. (610 aa)
FYBSH3 domain-containing protein. (635 aa)
NGFRNerve growth factor receptor. (427 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (584 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SRCTyrosine-protein kinase. (458 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1039 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (2011 aa)
PFN1Profilin; Belongs to the profilin family. (165 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (721 aa)
RALGDSUncharacterized protein. (913 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1027 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1749 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
CTNND1Catenin delta 1. (975 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (905 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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