STRINGSTRING
BAD BAD SLC8A1 SLC8A1 PDE3B PDE3B GATA4 GATA4 PPP3CB PPP3CB GUCY1B1 GUCY1B1 GNA13 GNA13 KCNMB3 KCNMB3 ADCY9 ADCY9 IRS1 IRS1 SLC8A3 SLC8A3 PLN PLN CNGA1 CNGA1 CREB3L4 CREB3L4 PLCB1 PLCB1 CALML5 CALML5 ADRA2B ADRA2B PLCB4 PLCB4 MAPK1 MAPK1 CALML3 CALML3 NFATC4 NFATC4 LOC103786316 LOC103786316 ADCY7 ADCY7 EDNRB EDNRB CACNA1F CACNA1F ATF2 ATF2 NPPC NPPC ITPR2 ITPR2 MYLK3 MYLK3 ATP2B3 ATP2B3 NPPB NPPB GNAQ GNAQ TRPC6 TRPC6 MAP2K1 MAP2K1 SRF SRF AKT2 AKT2 ATP1A4 ATP1A4 PPP1CB PPP1CB LOC100980358 LOC100980358 MAP2K2 MAP2K2 CREB3L1 CREB3L1 SLC25A31 SLC25A31 MEF2B MEF2B MYLK MYLK PPP1CC PPP1CC SLC8A2 SLC8A2 GNAI1 GNAI1 NPR2 NPR2 CREB5 CREB5 PPP1R12A PPP1R12A NFATC1 NFATC1 ADCY6 ADCY6 CACNA1C CACNA1C RHOA RHOA GNAI2 GNAI2 KCNMA1 KCNMA1 PPIF PPIF PRKCE PRKCE CALML4 CALML4 ATF6B ATF6B GTF2I GTF2I ADRB3 ADRB3 PIK3R6 PIK3R6 PRKG1 PRKG1 GTF2IRD1 GTF2IRD1 ADORA1 ADORA1 BDKRB2 BDKRB2 CREB3 CREB3 ATP1A2 ATP1A2 VDAC3 VDAC3 CREB3L3 CREB3L3 ADCY2 ADCY2 MEF2A MEF2A RAF1 RAF1 NPR1 NPR1 AKT3 AKT3 GUCY1A1 GUCY1A1 ATP1B2 ATP1B2 KCNMB2 KCNMB2 RGS2 RGS2 AGTR1 AGTR1 ADCY5 ADCY5 PIK3R5 PIK3R5 ATP1B1 ATP1B1 ADRB2 ADRB2 ATP2A1 ATP2A1 KCNMB4 KCNMB4 VASP VASP SLC25A5 SLC25A5 VDAC1 VDAC1 CNGB1 CNGB1 ADCY8 ADCY8 PDE2A PDE2A NPPA NPPA EDNRA EDNRA CALM3 CALM3 SLC25A4 SLC25A4 MYH6 MYH6 KCNU1 KCNU1 GNAI3 GNAI3 ADCY3 ADCY3 ADCY4 ADCY4 ADRA1D ADRA1D MYH7 MYH7 MEF2D MEF2D KCNMB1 KCNMB1 ATP2A3 ATP2A3 GNA11 GNA11 ROCK2 ROCK2 ATP1B3 ATP1B3 NOS3 NOS3 ATF4 ATF4 ADCY1 ADCY1 IRS4 IRS4 ATP1A1 ATP1A1 PLCB2 PLCB2 ATP1B4 ATP1B4 CALML6 CALML6 AKT1 AKT1 ROCK1 ROCK1 CACNA1S CACNA1S KCNJ8 KCNJ8 PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 NFATC2 NFATC2 PRKG2 PRKG2 MYLK2 MYLK2 NFATC3 NFATC3 MYL9 MYL9 PDE5A PDE5A ATP2B4 ATP2B4 ADRA1B ADRA1B OPRD1 OPRD1 PDE3A PDE3A ATP2A2 ATP2A2 PPP3CA PPP3CA CREB3L2 CREB3L2 PIK3CG PIK3CG CACNA1D CACNA1D ADRA1A ADRA1A ATP2B1 ATP2B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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BADBCL2 associated agonist of cell death. (168 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
PDE3BPhosphodiesterase. (1112 aa)
GATA4GATA binding protein 4. (396 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (644 aa)
GNA13Uncharacterized protein. (282 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (278 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
SLC8A3Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
ADRA2BAdrenoceptor alpha 2B. (448 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
LOC103786316FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NPPCNatriuretic peptide C. (126 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
NPPBNatriuretic peptide B. (134 aa)
GNAQG protein subunit alpha q. (313 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SRFSerum response factor. (414 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
LOC100980358Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
MEF2BMyocyte enhancer factor 2B. (368 aa)
MYLKMyosin light chain kinase. (1847 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (908 aa)
GNAI1G protein subunit alpha i1. (323 aa)
NPR2Guanylate cyclase. (1047 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1026 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
RHOAUncharacterized protein. (206 aa)
GNAI2G protein subunit alpha i2. (355 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1194 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CALML4Calmodulin like 4. (196 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GTF2IGeneral transcription factor IIi. (998 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (374 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
PRKG1cGMP-dependent protein kinase. (671 aa)
GTF2IRD1GTF2I repeat domain containing 1. (942 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
MEF2AMyocyte enhancer factor 2A. (505 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
NPR1Guanylate cyclase. (1060 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (267 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (263 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ADRB2Adrenoceptor beta 2. (429 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (873 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
VDAC1Voltage dependent anion channel 1. (289 aa)
CNGB1Cyclic nucleotide gated channel subunit beta 1. (1231 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PDE2APhosphodiesterase. (941 aa)
NPPANatriuretic peptide A. (153 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (261 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1165 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADRA1DAdrenoceptor alpha 1D. (513 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
MEF2DMyocyte enhancer factor 2D. (520 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1017 aa)
GNA11G protein subunit alpha 11. (319 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (242 aa)
NOS3Nitric oxide synthase 3. (997 aa)
ATF4Activating transcription factor 4. (340 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
IRS4Insulin receptor substrate 4. (1194 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CALML6Calmodulin like 6. (181 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
MYL9Myosin light chain 9. (172 aa)
PDE5APhosphodiesterase. (875 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ADRA1BAdrenoceptor alpha 1B. (457 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PDE3APhosphodiesterase. (1141 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1034 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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