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TRAF2 TRAF2 MAPK8 MAPK8 PIK3R3 PIK3R3 SGMS1 SGMS1 GNA13 GNA13 CERS3 CERS3 S1PR1 S1PR1 PPP2R5A PPP2R5A PPP2R1A PPP2R1A TNF TNF TNFRSF1A TNFRSF1A CTSD CTSD S1PR2 S1PR2 PPP2R2D PPP2R2D PLCB1 PLCB1 PPP2R5E PPP2R5E PLCB4 PLCB4 SPHK1 SPHK1 MAPK1 MAPK1 FCER1G FCER1G SPTLC2 SPTLC2 LOC100969990 LOC100969990 FCER1A FCER1A PIK3R2 PIK3R2 PIK3CA PIK3CA GNAQ GNAQ MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 PPP2R5D PPP2R5D ASAH1 ASAH1 ENSPPAP00000011278 ENSPPAP00000011278 BID BID MAP2K2 MAP2K2 MAPK12 MAPK12 PPP2CA PPP2CA GAB2 GAB2 PPP2R3C PPP2R3C GNAI1 GNAI1 SGPP2 SGPP2 RAC2 RAC2 SMPD2 SMPD2 SMPD1 SMPD1 RHOA RHOA PRKCA PRKCA PIK3CB PIK3CB GNAI2 GNAI2 CERS6 CERS6 BCL2 BCL2 NFKB1 NFKB1 RELA RELA PPP2R5B PPP2R5B RAC1 RAC1 PRKCE PRKCE LOC100989777 LOC100989777 DEGS1 DEGS1 ADORA1 ADORA1 BDKRB2 BDKRB2 DEGS2 DEGS2 SPHK2 SPHK2 PRKCB PRKCB CERS5 CERS5 PPP2R2A PPP2R2A RAF1 RAF1 AKT3 AKT3 PPP2CB PPP2CB TRADD TRADD SGPL1 SGPL1 FYN FYN S1PR5 S1PR5 MAPK11 MAPK11 CERS1 CERS1 ACER2 ACER2 PLD2 PLD2 SPTLC3 SPTLC3 MAPK13 MAPK13 NRAS NRAS ASAH2 ASAH2 MAPK9 MAPK9 GNAI3 GNAI3 ROCK2 ROCK2 PPP2R3A PPP2R3A NOS3 NOS3 PPP2R2C PPP2R2C LOC100995377 LOC100995377 CERS2 CERS2 BAX BAX PLCB2 PLCB2 AKT1 AKT1 ROCK1 ROCK1 PLCB3 PLCB3 MAP3K5 MAP3K5 MS4A2 MS4A2 SGMS2 SGMS2 CERS4 CERS4 ACER1 ACER1 OPRD1 OPRD1 SGPP1 SGPP1 MAPK14 MAPK14 PIK3R1 PIK3R1 SPTLC1 SPTLC1 PRKCZ PRKCZ MAPK10 MAPK10 PPP2R2B PPP2R2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
GNA13Uncharacterized protein. (282 aa)
CERS3Ceramide synthase 3. (383 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (613 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (469 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SPHK1Sphingosine kinase 1. (470 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
FCER1GUncharacterized protein. (112 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (564 aa)
LOC100969990Uncharacterized protein. (659 aa)
FCER1AFc fragment of IgE receptor Ia. (260 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
GNAQG protein subunit alpha q. (313 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa)
ASAH1Uncharacterized protein; Belongs to the acid ceramidase family. (377 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
PPP2CASerine/threonine-protein phosphatase. (294 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GNAI1G protein subunit alpha i1. (323 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (326 aa)
RAC2Rac family small GTPase 2. (192 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
SMPD1Saposin B-type domain-containing protein. (504 aa)
RHOAUncharacterized protein. (206 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CERS6Ceramide synthase 6. (392 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
RAC1Uncharacterized protein. (224 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC100989777Uncharacterized protein. (191 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
SPHK2Sphingosine kinase 2. (663 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
CERS5Ceramide synthase 5. (391 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
FYNTyrosine-protein kinase. (537 aa)
S1PR5Sphingosine-1-phosphate receptor 5; Belongs to the G-protein coupled receptor 1 family. (391 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CERS1TLC domain-containing protein. (296 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
PLD2Phospholipase. (915 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ASAH2Neutral ceramidase. (734 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
NOS3Nitric oxide synthase 3. (997 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (535 aa)
LOC100995377Uncharacterized protein. (557 aa)
CERS2Ceramide synthase 2. (380 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
MS4A2Membrane spanning 4-domains A2. (244 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
CERS4Ceramide synthase 4. (394 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
SGPP1acidPPc domain-containing protein. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
SPTLC1Aminotran_1_2 domain-containing protein. (308 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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