140 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRM8	ANF_receptor domain-containing protein. (184 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (785 aa)
	LPAR6	Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	PIP5K1B	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
	DGKA	Diacylglycerol kinase. (735 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
	GNA13	Uncharacterized protein. (282 aa)
	PDGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
	LPAR5	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	CXCR2	C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	CXCR1	C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	GRM2	Glutamate metabotropic receptor 2. (872 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	SPHK1	Sphingosine kinase 1. (470 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	FCER1G	Uncharacterized protein. (112 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	AVPR1A	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
	DGKH	Diacylglycerol kinase. (1156 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (485 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	RHEB	Uncharacterized protein. (173 aa)
	ENSPPAP00000008696	Ig-like domain-containing protein. (147 aa)
	FCER1A	Fc fragment of IgE receptor Ia. (260 aa)
	ENSPPAP00000009755	Ig-like domain-containing protein. (116 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PIK3R2	Uncharacterized protein. (663 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
	SHC3	SHC adaptor protein 3. (501 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PLA2G4E	Phospholipase A2. (868 aa)
	GRM5	Glutamate metabotropic receptor 5. (1195 aa)
	AVP	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (134 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
	RGL4	Ras-GEF domain-containing protein. (588 aa)
	AGPAT3	1-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
	ARF1	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	GAB2	GRB2 associated binding protein 2. (675 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (676 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	GRM7	Glutamate metabotropic receptor 7. (922 aa)
	DNM3	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	RHOA	Uncharacterized protein. (206 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	LOC100974009	Uncharacterized protein. (184 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	CYTH3	Cytohesin 3. (397 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	GNAS	GNAS complex locus. (1043 aa)
	ARF6	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	RRAS	RAS related. (176 aa)
	PDGFD	Platelet derived growth factor D. (329 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
	TSC2	TSC complex subunit 2. (1807 aa)
	DGKK	Diacylglycerol kinase. (1258 aa)
	PTGFR	Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	SPHK2	Sphingosine kinase 2. (663 aa)
	DGKG	Diacylglycerol kinase. (791 aa)
	PLA2G4F	Phospholipase A2. (849 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
	AVPR2	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	RALB	RAS like proto-oncogene B. (254 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5. (359 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
	DGKB	Diacylglycerol kinase. (803 aa)
	PLD2	Phospholipase. (915 aa)
	GRM6	Glutamate metabotropic receptor 6. (752 aa)
	GRM3	Glutamate metabotropic receptor 3. (879 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	DGKE	Diacylglycerol kinase. (567 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	DGKQ	Diacylglycerol kinase. (899 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (923 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	DGKZ	Diacylglycerol kinase. (1117 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	CYTH1	Cytohesin 1. (399 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	AGPAT1	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	AGPAT2	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	PLA2G4D	Phospholipase A2. (818 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	LOC103785316	Ig-like domain-containing protein. (221 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
	MS4A2	Membrane spanning 4-domains A2. (244 aa)
	CYTH2	Uncharacterized protein. (388 aa)
	ENSPPAP00000037256	PIPK domain-containing protein. (572 aa)
	RALGDS	Uncharacterized protein. (913 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	LPAR3	Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	PLPP2	Phospholipid phosphatase 2. (287 aa)
	RRAS2	Uncharacterized protein. (169 aa)
	GRM1	Glutamate metabotropic receptor 1. (1194 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (905 aa)
	SHC2	Uncharacterized protein. (539 aa)
	LOC100976973	PIPK domain-containing protein. (537 aa)
	GRM4	Glutamate metabotropic receptor 4. (912 aa)
	PLA2G4C	Phospholipase A2 group IVC. (529 aa)
	PLPP3	acidPPc domain-containing protein. (311 aa)
	LPAR2	Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	DGKD	Diacylglycerol kinase. (1254 aa)
	EGFR	Receptor protein-tyrosine kinase. (1201 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSPPAP00000033273	ENSPPAP00000023934	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.573
ADCY1	ADCY3	ENSPPAP00000033273	ENSPPAP00000030669	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY4	ENSPPAP00000033273	ENSPPAP00000031100	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.480
ADCY1	ADCY5	ENSPPAP00000033273	ENSPPAP00000025948	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY6	ENSPPAP00000033273	ENSPPAP00000015584	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.463
ADCY1	ADCY7	ENSPPAP00000033273	ENSPPAP00000007130	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.605
ADCY1	ADCY8	ENSPPAP00000033273	ENSPPAP00000028968	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.952
ADCY1	ADCY9	ENSPPAP00000033273	ENSPPAP00000003795	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.712
ADCY1	AKT1	ENSPPAP00000033273	ENSPPAP00000034920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.693
ADCY1	AKT2	ENSPPAP00000033273	ENSPPAP00000010803	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.693
ADCY1	AKT3	ENSPPAP00000033273	ENSPPAP00000024904	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.693
ADCY1	GNAS	ENSPPAP00000033273	ENSPPAP00000019582	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.980
ADCY1	GNAS-2	ENSPPAP00000033273	ENSPPAP00000020165	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.902
ADCY1	PLCB1	ENSPPAP00000033273	ENSPPAP00000005635	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.495
ADCY1	PRKCA	ENSPPAP00000033273	ENSPPAP00000017194	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.928
ADCY1	RAPGEF3	ENSPPAP00000033273	ENSPPAP00000041160	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.948
ADCY1	RAPGEF4	ENSPPAP00000033273	ENSPPAP00000030207	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 4.	0.930
ADCY2	ADCY1	ENSPPAP00000023934	ENSPPAP00000033273	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.573
ADCY2	ADCY3	ENSPPAP00000023934	ENSPPAP00000030669	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.452
ADCY2	ADCY4	ENSPPAP00000023934	ENSPPAP00000031100	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.455