STRINGSTRING
SPAM1 SPAM1 CLN5 CLN5 CTSG CTSG AP3M1 AP3M1 MFSD8 MFSD8 ARSA ARSA NPC1 NPC1 CTSD CTSD SGSH SGSH GGA1 GGA1 IGF2R IGF2R ACP5 ACP5 GAA GAA CTSA CTSA PSAPL1 PSAPL1 CD68 CD68 SLC17A5 SLC17A5 GALNS GALNS NAGLU NAGLU LOC100989682 LOC100989682 ASAH1 ASAH1 CLTC CLTC GLA GLA LAMP2 LAMP2 GBA GBA MANBA MANBA CTSB CTSB GGA3 GGA3 HYAL2 HYAL2 ENTPD4 ENTPD4 AP1G2 AP1G2 TCIRG1 TCIRG1 CTSS CTSS CTSL CTSL CLTCL1 CLTCL1 LAPTM5 LAPTM5 DNASE2B DNASE2B ARSG ARSG GALC GALC AP1G1 AP1G1 AP1S1 AP1S1 SMPD1 SMPD1 SUMF1 SUMF1 MAN2B1 MAN2B1 ATP6V0A4 ATP6V0A4 CTSW CTSW ATP6V0D2 ATP6V0D2 AP1B1 AP1B1 SCARB2 SCARB2 DNASE2 DNASE2 NAGA NAGA ATP6V0A1 ATP6V0A1 LAMP1 LAMP1 SORT1 SORT1 SLC11A1 SLC11A1 TPP1 TPP1 MCOLN1 MCOLN1 AP3S1 AP3S1 HYAL3 HYAL3 LAPTM4B LAPTM4B ATP6AP1 ATP6AP1 AP3B2 AP3B2 ATP6V0A2 ATP6V0A2 CD164 CD164 M6PR M6PR AGA AGA PSAP PSAP LAPTM4A LAPTM4A AP3D1 AP3D1 CTNS CTNS HEXA HEXA LIPA LIPA FUCA2 FUCA2 GM2A GM2A NAPSA NAPSA NEU1 NEU1 CTSE CTSE HYAL1 HYAL1 GLB1 GLB1 ATP6V1H ATP6V1H AP4B1 AP4B1 SLC11A2 SLC11A2 LGMN LGMN AP3B1 AP3B1 NPC2 NPC2 ATP6V0B ATP6V0B CTSC CTSC IDS IDS FUCA1 FUCA1 CD63 CD63 ARSB ARSB GNPTG GNPTG AP1S3 AP1S3 AP4E1 AP4E1 CTSV CTSV CTSH CTSH GNPTAB GNPTAB AP3M2 AP3M2 ATP6V0C ATP6V0C AP4S1 AP4S1 CTSK CTSK CTSO CTSO AP1M1 AP1M1 HGSNAT HGSNAT PLA2G15 PLA2G15 ACP2 ACP2 AP1S2 AP1S2 ABCA2 ABCA2 AP1M2 AP1M2 HEXB HEXB AP4M1 AP4M1 LITAF LITAF CTSZ CTSZ PPT2 PPT2 ABCB9 ABCB9 HYAL4 HYAL4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPAM1Hyaluronidase. (511 aa)
CLN5CLN5 intracellular trafficking protein. (389 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
AP3M1AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
MFSD8Major facilitator superfamily domain containing 8. (521 aa)
ARSAArylsulfatase A. (509 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (613 aa)
SGSHN-sulfoglucosamine sulfohydrolase. (501 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (639 aa)
IGF2RInsulin like growth factor 2 receptor. (2464 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (952 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (498 aa)
PSAPL1Uncharacterized protein. (253 aa)
CD68CD68 molecule. (354 aa)
SLC17A5Solute carrier family 17 member 5. (495 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (504 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (682 aa)
LOC100989682Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (410 aa)
ASAH1Uncharacterized protein; Belongs to the acid ceramidase family. (377 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
GLAAlpha-galactosidase. (429 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
GBAGlucosylceramidase. (481 aa)
MANBAMannosidase beta. (879 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (723 aa)
HYAL2Hyaluronidase. (473 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (617 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
ARSGArylsulfatase G. (525 aa)
GALCGalactosylceramidase. (685 aa)
AP1G1AP-1 complex subunit gamma. (844 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
SMPD1Saposin B-type domain-containing protein. (504 aa)
SUMF1Sulfatase modifying factor 1. (374 aa)
MAN2B1Alpha-mannosidase. (1011 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (376 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
AP1B1AP complex subunit beta. (947 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (360 aa)
NAGAAlpha-galactosidase. (411 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
LAMP1Lysosomal associated membrane protein 1. (465 aa)
SORT1Sortilin. (569 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
TPP1Tripeptidyl peptidase 1. (563 aa)
MCOLN1Mucolipin 1. (580 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
LAPTM4BUncharacterized protein. (226 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
AP3B2AP-3 complex subunit beta. (1055 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
CD164CD164 molecule. (197 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (277 aa)
AGAAspartylglucosaminidase. (346 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (534 aa)
LAPTM4ALysosomal protein transmembrane 4 alpha. (233 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1207 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
HEXABeta-hexosaminidase. (538 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
FUCA2Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (465 aa)
GM2AGM2 ganglioside activator. (193 aa)
NAPSANapsin A aspartic peptidase; Belongs to the peptidase A1 family. (420 aa)
NEU1Neuraminidase 1. (417 aa)
CTSECathepsin E; Belongs to the peptidase A1 family. (396 aa)
HYAL1Hyaluronidase. (435 aa)
GLB1Beta-galactosidase. (710 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
SLC11A2Solute carrier family 11 member 2. (590 aa)
LGMNLegumain. (433 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
NPC2ML domain-containing protein. (221 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
IDSIduronate 2-sulfatase. (550 aa)
FUCA1Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (466 aa)
CD63Tetraspanin. (238 aa)
ARSBArylsulfatase B. (478 aa)
GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma. (305 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (163 aa)
AP4E1Adaptor related protein complex 4 subunit epsilon 1. (1142 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (334 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1256 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
AP4S1Adaptor related protein complex 4 subunit sigma 1. (159 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (321 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (424 aa)
HGSNATUncharacterized protein. (339 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
ACP2Acid phosphatase 2, lysosomal; Belongs to the histidine acid phosphatase family. (423 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
ABCA2ATP binding cassette subfamily A member 2. (2446 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (425 aa)
HEXBBeta-hexosaminidase. (556 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (460 aa)
LITAFLipopolysaccharide induced TNF factor. (161 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
PPT2Palmitoyl-protein thioesterase 2. (308 aa)
ABCB9ATP binding cassette subfamily B member 9. (766 aa)
HYAL4Hyaluronidase. (481 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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