STRINGSTRING
CD36 CD36 HLA-C HLA-C CALR CALR TUBB1 TUBB1 ATP6V1G1 ATP6V1G1 SEC61B SEC61B TUBA4A TUBA4A LOC100990258 LOC100990258 LOC100992883 LOC100992883 ATP6V1D ATP6V1D LOC100986914 LOC100986914 TUBB TUBB VAMP3 VAMP3 THBS1 THBS1 LOC100979649 LOC100979649 SEC61A1 SEC61A1 TFRC TFRC ITGB5 ITGB5 TUBB4A TUBB4A NCF4 NCF4 ATP6V1B1 ATP6V1B1 STX7 STX7 TLR2 TLR2 OLR1 OLR1 FCAR FCAR MRC2 MRC2 HLA-DOB HLA-DOB ENSPPAP00000008696 ENSPPAP00000008696 LOC100993508 LOC100993508 TUBA3C TUBA3C ENSPPAP00000009755 ENSPPAP00000009755 CYBB CYBB DYNC1I2 DYNC1I2 LAMP2 LAMP2 COLEC12 COLEC12 LOC100980448 LOC100980448 TAP1 TAP1 LOC100986750 LOC100986750 PIK3C3 PIK3C3 TCIRG1 TCIRG1 ATP6V1C1 ATP6V1C1 CTSS CTSS ITGB3 ITGB3 CTSL CTSL FCGR2A FCGR2A TLR4 TLR4 HLA-G HLA-G CORO1A CORO1A NCF1 NCF1 HLA-DPA1 HLA-DPA1 ATP6V0A4 ATP6V0A4 ATP6V1G2 ATP6V1G2 RAC1 RAC1 ATP6V0D2 ATP6V0D2 ATP6V1E2 ATP6V1E2 TUBA1C TUBA1C LOC100989777 LOC100989777 Papa-A Papa-A TUBA8 TUBA8 STX18 STX18 CANX CANX TAP2 TAP2 LOC100971602 LOC100971602 TUBB4B TUBB4B ATP6V0A1 ATP6V0A1 SEC61G SEC61G THBS4 THBS4 LAMP1 LAMP1 C1R C1R RAB5B RAB5B DYNC1H1 DYNC1H1 ITGAV ITGAV C3 C3 TUBAL3 TUBAL3 ATP6AP1 ATP6AP1 HLA-DOA HLA-DOA DYNC1LI1 DYNC1LI1 MSR1 MSR1 ATP6V0A2 ATP6V0A2 M6PR M6PR ATP6V0E1 ATP6V0E1 RAB5C RAB5C ITGAM ITGAM RAB7B RAB7B ACTG1 ACTG1 ATP6V1E1 ATP6V1E1 MHC-DMB MHC-DMB SEC61A2 SEC61A2 HLA-DQA2 HLA-DQA2 LOC100984838 LOC100984838 HLA-E HLA-E MARCO MARCO ATP6V1H ATP6V1H COLEC11 COLEC11 NCF2 NCF2 LOC100993847 LOC100993847 ITGB1 ITGB1 PIKFYVE PIKFYVE ENSPPAP00000031810 ENSPPAP00000031810 PLA2R1 PLA2R1 MPO MPO ATP6V0B ATP6V0B FCGR1A FCGR1A LOC100990567 LOC100990567 THBS2 THBS2 DYNC2H1 DYNC2H1 SFTPD SFTPD LOC103785316 LOC103785316 COMP COMP ITGA5 ITGA5 MBL2 MBL2 STX12 STX12 HLA-DQB1 HLA-DQB1 HLA-DQB2 HLA-DQB2 ATP6V0C ATP6V0C CD14 CD14 HLA-DPB1 HLA-DPB1 RAB5A RAB5A ATP6V1A ATP6V1A HLA-DRA HLA-DRA EEA1 EEA1 DYNC1LI2 DYNC1LI2 HGS HGS TUBA1B TUBA1B MRC1 MRC1 ATP6V1B2 ATP6V1B2 DYNC1I1 DYNC1I1 NOS1 NOS1 ITGA2 ITGA2 THBS3 THBS3 CD209 CD209
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
HLA-CMajor histocompatibility complex, class I, C; Belongs to the MHC class I family. (397 aa)
CALRCalreticulin. (417 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
LOC100990258V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
LOC100992883Uncharacterized protein; Belongs to the tubulin family. (615 aa)
ATP6V1DUncharacterized protein. (192 aa)
LOC100986914Uncharacterized protein. (210 aa)
TUBBTubulin domain-containing protein. (113 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (116 aa)
THBS1Thrombospondin 1. (1173 aa)
LOC100979649Ig-like domain-containing protein. (170 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (498 aa)
TFRCTransferrin receptor. (773 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (803 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
NCF4Uncharacterized protein. (368 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
OLR1Oxidized low density lipoprotein receptor 1. (273 aa)
FCARFc fragment of IgA receptor. (286 aa)
MRC2Mannose receptor C type 2. (1479 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (266 aa)
ENSPPAP00000008696Ig-like domain-containing protein. (147 aa)
LOC100993508Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
TUBA3CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
ENSPPAP00000009755Ig-like domain-containing protein. (116 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (613 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
COLEC12Collectin subfamily member 12. (742 aa)
LOC100980448G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the tubulin family. (796 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
LOC100986750Ig-like domain-containing protein. (287 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
FCGR2AFc fragment of IgG receptor IIa. (316 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
HLA-GMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
RAC1Uncharacterized protein. (224 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (519 aa)
LOC100989777Uncharacterized protein. (191 aa)
Papa-AIGc1 domain-containing protein; Belongs to the MHC class I family. (406 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
STX18Syntaxin 18. (336 aa)
CANXCalnexin. (592 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (724 aa)
LOC100971602Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (433 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
THBS4Thrombospondin 4. (870 aa)
LAMP1Lysosomal associated membrane protein 1. (465 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (704 aa)
RAB5BRAB5B, member RAS oncogene family. (223 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4581 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
C3Complement C3. (1614 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
MSR1Macrophage scavenger receptor 1. (460 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (277 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
RAB5CRAB5C, member RAS oncogene family. (249 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
ACTG1Actin gamma 1. (375 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
MHC-DMBIg-like domain-containing protein. (276 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (476 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
LOC100984838Uncharacterized protein. (334 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (352 aa)
MARCOMacrophage receptor with collagenous structure. (520 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
COLEC11Collectin subfamily member 11. (285 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
LOC100993847Ig-like domain-containing protein. (270 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
ENSPPAP00000031810MHC_I-like_Ag-recog domain-containing protein. (194 aa)
PLA2R1Phospholipase A2 receptor 1. (1466 aa)
MPOMyeloperoxidase. (745 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
FCGR1AUncharacterized protein. (368 aa)
LOC100990567C-type lectin domain-containing protein. (256 aa)
THBS2Thrombospondin 2. (1172 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
SFTPDSurfactant protein D. (375 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
COMPCartilage oligomeric matrix protein. (762 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1046 aa)
MBL2Mannose binding lectin 2. (270 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CD14CD14 molecule. (384 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
EEA1Early endosome antigen 1. (1411 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (481 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
MRC1Mannose receptor C-type 1. (1456 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (525 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (628 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
THBS3Thrombospondin 3. (956 aa)
CD209C-type lectin domain-containing protein. (312 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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