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SLC8A1 SLC8A1 TPM1 TPM1 CACNB3 CACNB3 PRKACG PRKACG PRKACA PRKACA KCNE1 KCNE1 PPP2R5A PPP2R5A ADCY9 ADCY9 CACNA2D3 CACNA2D3 PPP2R1A PPP2R1A SLC8A3 SLC8A3 PLN PLN CREB3L4 CREB3L4 PPP2R2D PPP2R2D TPM3-2 TPM3-2 PLCB1 PLCB1 CALML5 CALML5 PPP2R5E PPP2R5E PLCB4 PLCB4 MAPK1 MAPK1 CACNG2 CACNG2 CALML3 CALML3 AGTR2 AGTR2 LOC103786316 LOC103786316 ADCY7 ADCY7 CACNA2D1 CACNA2D1 CACNG1 CACNG1 AGT AGT CACNA1F CACNA1F ATF2 ATF2 MYL2 MYL2 CACNB4 CACNB4 ATP2B3 ATP2B3 GNAQ GNAQ AKT2 AKT2 ATP1A4 ATP1A4 PPP2R5D PPP2R5D PPP1CB PPP1CB CREB3L1 CREB3L1 MAPK12 MAPK12 ACTC1 ACTC1 PPP2CA PPP2CA PPP1CC PPP1CC SLC8A2 SLC8A2 PPP2R3C PPP2R3C GNAI1 GNAI1 SCN7A SCN7A PPP1R1A PPP1R1A CREB5 CREB5 TPM2 TPM2 CACNG4 CACNG4 ADCY6 ADCY6 LOC100979041 LOC100979041 SCN1B SCN1B CACNG6 CACNG6 CACNA1C CACNA1C CACNA2D4 CACNA2D4 PRKCA PRKCA GNAI2 GNAI2 PRKACB PRKACB BCL2 BCL2 MYL4 MYL4 PPP2R5B PPP2R5B CACNB2 CACNB2 GNAS GNAS GNAS-2 GNAS-2 CALML4 CALML4 ATF6B ATF6B TNNI3 TNNI3 PIK3R6 PIK3R6 CREB3 CREB3 ATP1A2 ATP1A2 CREB3L3 CREB3L3 TPM3 TPM3 ADCY2 ADCY2 PPP2R2A PPP2R2A KCNQ1 KCNQ1 AKT3 AKT3 PPP2CB PPP2CB ATP1B2 ATP1B2 AGTR1 AGTR1 MAPK11 MAPK11 ADCY5 ADCY5 PIK3R5 PIK3R5 ATP1B1 ATP1B1 ADRB2 ADRB2 SCN5A SCN5A ATP2A1 ATP2A1 TNNC1 TNNC1 CACNG3 CACNG3 ADCY8 ADCY8 CALM3 CALM3 MYH6 MYH6 SCN4B SCN4B MAPK13 MAPK13 RAPGEF4 RAPGEF4 RPS6KA5 RPS6KA5 GNAI3 GNAI3 MYL3 MYL3 ADCY3 ADCY3 ADCY4 ADCY4 ADRA1D ADRA1D MYH7 MYH7 ATP2A3 ATP2A3 ATP1B3 ATP1B3 PPP2R3A PPP2R3A PPP2R2C PPP2R2C ATF4 ATF4 ADCY1 ADCY1 CACNA2D2 CACNA2D2 ATP1A1 ATP1A1 PLCB2 PLCB2 ATP1B4 ATP1B4 CALML6 CALML6 TPM4 TPM4 CACNG5 CACNG5 AKT1 AKT1 CACNA1S CACNA1S PLCB3 PLCB3 ATP2B4 ATP2B4 ADRA1B ADRA1B MAPK14 MAPK14 CAMK2A CAMK2A ATP2A2 ATP2A2 CREB3L2 CREB3L2 PPP2R2B PPP2R2B PIK3CG PIK3CG RAPGEF3 RAPGEF3 CACNA1D CACNA1D ADRA1A ADRA1A SLC9A1 SLC9A1 RYR2 RYR2 ATP2B1 ATP2B1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (488 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
KCNE1Uncharacterized protein. (132 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1067 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SLC8A3Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
TPM3-2Uncharacterized protein. (92 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (469 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
LOC103786316FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MYL2Myosin light chain 2. (166 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
GNAQG protein subunit alpha q. (313 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
PPP2CASerine/threonine-protein phosphatase. (294 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (908 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GNAI1G protein subunit alpha i1. (323 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1682 aa)
PPP1R1AProtein phosphatase 1 regulatory inhibitor subunit 1A. (177 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (322 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (339 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
LOC100979041Uncharacterized protein. (245 aa)
SCN1BIg-like domain-containing protein. (215 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (240 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1154 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
MYL4Myosin light chain 4. (193 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
GNASGNAS complex locus. (1043 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
TPM3Uncharacterized protein; Belongs to the tropomyosin family. (285 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (557 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (267 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ADRB2Adrenoceptor beta 2. (429 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2020 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (873 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (923 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MYL3Myosin light chain 3. (195 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADRA1DAdrenoceptor alpha 1D. (513 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1017 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (242 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (535 aa)
ATF4Activating transcription factor 4. (340 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1126 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CALML6Calmodulin like 6. (181 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ADRA1BAdrenoceptor alpha 1B. (457 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1034 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (905 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
RYR2Ryanodine receptor 2. (4948 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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