STRINGSTRING
SLC8A1 SLC8A1 PDE3B PDE3B LOC100980803 LOC100980803 RPS6KB2 RPS6KB2 APLNR APLNR GNA13 GNA13 PRKACG PRKACG PRKACA PRKACA PLAT PLAT ADCY9 ADCY9 NOTCH3 NOTCH3 BECN2 BECN2 SLC8A3 SLC8A3 PLCB1 PLCB1 CALML5 CALML5 GNG2 GNG2 PLCB4 PLCB4 SPHK1 SPHK1 MAPK1 MAPK1 CALML3 CALML3 ADCY7 ADCY7 GNGT1 GNGT1 UCP1 UCP1 MYL2 MYL2 SMAD4 SMAD4 ITPR2 ITPR2 GNGT2 GNGT2 MYLK3 MYLK3 RPS6KB1 RPS6KB1 GNAQ GNAQ PRKAG3 PRKAG3 MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS MAP2K2 MAP2K2 GNB2 GNB2 MEF2B MEF2B MYLK MYLK EGR1 EGR1 PRKAG2 PRKAG2 GABARAP GABARAP PIK3C3 PIK3C3 SLC8A2 SLC8A2 PIK3R4 PIK3R4 GNAI1 GNAI1 TGFBR1 TGFBR1 ADCY6 ADCY6 RYR3 RYR3 GNAI2 GNAI2 PRKACB PRKACB HDAC5 HDAC5 GNG3 GNG3 MYL4 MYL4 PRKCE PRKCE NOS2 NOS2 RYR1 RYR1 GABARAPL2 GABARAPL2 CALML4 CALML4 GNG8 GNG8 GNG4 GNG4 ADCY10 ADCY10 RRAS RRAS PRKAB1 PRKAB1 PIK3R6 PIK3R6 SMAD3 SMAD3 SPHK2 SPHK2 JAG1 JAG1 PPARGC1A PPARGC1A ADCY2 ADCY2 MEF2A MEF2A RAF1 RAF1 SMAD2 SMAD2 GABARAPL1 GABARAPL1 AKT3 AKT3 HDAC4 HDAC4 PRKAA1 PRKAA1 AGTR1 AGTR1 ADCY5 ADCY5 PIK3R5 PIK3R5 PRKAB2 PRKAB2 MRAS MRAS MTOR MTOR CCN2 CCN2 GNG7 GNG7 ADCY8 ADCY8 CALM3 CALM3 RPS6 RPS6 NRAS NRAS BECN1 BECN1 GNB1 GNB1 GNAI3 GNAI3 MYL3 MYL3 ADCY3 ADCY3 ADCY4 ADCY4 MEF2D MEF2D NOS3 NOS3 ADCY1 ADCY1 GNB5 GNB5 PLCB2 PLCB2 CALML6 CALML6 SPP1 SPP1 AKT1 AKT1 NRF1 NRF1 PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 MYLK2 MYLK2 GNG11 GNG11 PRKAG1 PRKAG1 CAMK4 CAMK4 LIPE LIPE RRAS2 RRAS2 GNB3 GNB3 PIK3CG PIK3CG PRKAA2 PRKAA2 SLC9A1 SLC9A1 GNB4 GNB4 SERPINE1 SERPINE1 NOS1 NOS1 RYR2 RYR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
PDE3BPhosphodiesterase. (1112 aa)
LOC100980803Uncharacterized protein. (117 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
GNA13Uncharacterized protein. (282 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
NOTCH3Notch receptor 3. (1981 aa)
BECN2Beclin 2. (431 aa)
SLC8A3Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SPHK1Sphingosine kinase 1. (470 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
MYL2Myosin light chain 2. (166 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
GNAQG protein subunit alpha q. (313 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
GNB2G protein subunit beta 2. (340 aa)
MEF2BMyocyte enhancer factor 2B. (368 aa)
MYLKMyosin light chain kinase. (1847 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (908 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
GNAI1G protein subunit alpha i1. (323 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
RYR3Ryanodine receptor 3. (4835 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MYL4Myosin light chain 4. (193 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
RYR1Ryanodine receptor 1. (4924 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
CALML4Calmodulin like 4. (196 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY10Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1610 aa)
RRASRAS related. (176 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SPHK2Sphingosine kinase 2. (663 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
MEF2AMyocyte enhancer factor 2A. (505 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GABARAPL1Uncharacterized protein. (117 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CCN2Cellular communication network factor 2. (334 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BECN1Beclin 1. (450 aa)
GNB1G protein subunit beta 1. (340 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MYL3Myosin light chain 3. (195 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MEF2DMyocyte enhancer factor 2D. (520 aa)
NOS3Nitric oxide synthase 3. (997 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
GNB5G protein subunit beta 5. (395 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
NRF1Nuclear respiratory factor 1. (503 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
LIPELipase E, hormone sensitive type. (1076 aa)
RRAS2Uncharacterized protein. (169 aa)
GNB3G protein subunit beta 3. (340 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
GNB4G protein subunit beta 4. (340 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (324 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa)
RYR2Ryanodine receptor 2. (4948 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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