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TRAF2 TRAF2 LILRA5 LILRA5 MAPK8 MAPK8 PPP3CB PPP3CB PIK3R3 PIK3R3 IRF9 IRF9 IFNAR1 IFNAR1 JAK1 JAK1 SOCS3 SOCS3 LOC100986914 LOC100986914 TNF TNF TNFRSF1A TNFRSF1A IKBKG IKBKG FOS FOS NOX1 NOX1 ACP5 ACP5 TNFRSF11A TNFRSF11A MAPK1 MAPK1 JUNB JUNB NCF4 NCF4 FOSL2 FOSL2 IFNGR2 IFNGR2 CALCR CALCR TAB1 TAB1 MAP3K7 MAP3K7 CYLD CYLD GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA MAP2K1 MAP2K1 AKT2 AKT2 PPARG PPARG SIRPB1 SIRPB1 SIRPG SIRPG MAPK12 MAPK12 GAB2 GAB2 TEC TEC TAB2 TAB2 TNFRSF11B TNFRSF11B ITGB3 ITGB3 FOSL1 FOSL1 SIRPA SIRPA NFKB2 NFKB2 TGFBR1 TGFBR1 FCGR2A FCGR2A NFATC1 NFATC1 RELB RELB LCK LCK ENSPPAP00000016909 ENSPPAP00000016909 TGFB1 TGFB1 NCF1 NCF1 PIK3CB PIK3CB NFKB1 NFKB1 IL1A IL1A IFNGR1 IFNGR1 RELA RELA LILRA4 LILRA4 RAC1 RAC1 LOC100989777 LOC100989777 IKBKB IKBKB SQSTM1 SQSTM1 TNFSF11 TNFSF11 IFNAR2 IFNAR2 OSCAR OSCAR AKT3 AKT3 LCP2 LCP2 FYN FYN FOSB FOSB MAPK11 MAPK11 FHL2 FHL2 SPI1 SPI1 MAP2K6 MAP2K6 SYK SYK MAPK13 MAPK13 CHUK CHUK MAPK9 MAPK9 LOC100984838 LOC100984838 NCF2 NCF2 BTK BTK MAP2K7 MAP2K7 TYK2 TYK2 TYROBP TYROBP IL1R1 IL1R1 PLCG2 PLCG2 STAT1 STAT1 FCGR1A FCGR1A IL1B IL1B AKT1 AKT1 BLNK BLNK NFATC2 NFATC2 MAP3K14 MAP3K14 TREM2 TREM2 CAMK4 CAMK4 MITF MITF CTSK CTSK CSF1R CSF1R NFKBIA NFKBIA MAPK14 MAPK14 IFNG IFNG PIK3R1 PIK3R1 PPP3CA PPP3CA CSF1 CSF1 MAPK10 MAPK10 TRAF6 TRAF6 ENSPPAP00000042341 ENSPPAP00000042341
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
IRF9Interferon regulatory factor 9. (392 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC100986914Uncharacterized protein. (210 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NOX1NADPH oxidase 1. (564 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
NCF4Uncharacterized protein. (368 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (309 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SIRPB1Uncharacterized protein. (427 aa)
SIRPGSignal regulatory protein gamma. (354 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
TECTyrosine-protein kinase. (631 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
SIRPASignal regulatory protein alpha. (504 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
FCGR2AFc fragment of IgG receptor IIa. (316 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
RELBRELB proto-oncogene, NF-kB subunit. (537 aa)
LCKTyrosine-protein kinase. (524 aa)
ENSPPAP00000016909Ig-like domain-containing protein. (481 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (499 aa)
RAC1Uncharacterized protein. (224 aa)
LOC100989777Uncharacterized protein. (191 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
SQSTM1Sequestosome 1. (440 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
IFNAR2Uncharacterized protein. (519 aa)
OSCAROsteoclast associated Ig-like receptor. (300 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
FYNTyrosine-protein kinase. (537 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
FHL2Four and a half LIM domains 2. (279 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
SYKTyrosine-protein kinase. (635 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC100984838Uncharacterized protein. (334 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
BTKTyrosine-protein kinase. (693 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
FCGR1AUncharacterized protein. (368 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
BLNKB cell linker. (417 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ENSPPAP00000042341Ig-like domain-containing protein. (484 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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