STRINGSTRING
BAD BAD EGF EGF COL1A1 COL1A1 COL4A6 COL4A6 BIRC2 BIRC2 MAPK8 MAPK8 PIP5K1B PIP5K1B PIK3R3 PIK3R3 PDGFA PDGFA LAMA3 LAMA3 IGF1 IGF1 MYL12B MYL12B CRKL CRKL COL6A5 COL6A5 ITGB4 ITGB4 THBS1 THBS1 ITGB5 ITGB5 PAK5 PAK5 MAPK1 MAPK1 RASGRF1 RASGRF1 VAV3 VAV3 VWF VWF TLN1 TLN1 COL4A1 COL4A1 COL2A1 COL2A1 ITGA6 ITGA6 ITGA9 ITGA9 SOS1 SOS1 IGF1R IGF1R COL6A1 COL6A1 MYL2 MYL2 CCND3 CCND3 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA MYLK3 MYLK3 LAMB3 LAMB3 SHC3 SHC3 MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS LAMB1 LAMB1 ENSPPAP00000011278 ENSPPAP00000011278 ZYX ZYX XIAP XIAP PPP1CB PPP1CB DIAPH1 DIAPH1 BIRC3 BIRC3 LAMA2 LAMA2 PDGFB PDGFB ILK ILK COL6A2 COL6A2 MYLK MYLK PIP5K1C PIP5K1C CRK CRK PPP1CC PPP1CC ITGB3 ITGB3 SHC1 SHC1 ITGA10 ITGA10 ITGA11 ITGA11 FLNB FLNB PPP1R12A PPP1R12A LAMA5 LAMA5 PGF PGF RAC2 RAC2 ITGA8 ITGA8 CDC42 CDC42 COL4A3 COL4A3 LAMA1 LAMA1 PARVB PARVB COL9A3 COL9A3 COL4A2 COL4A2 RHOA RHOA PRKCA PRKCA PIK3CB PIK3CB PDGFRA PDGFRA BCL2 BCL2 RAC1 RAC1 BCAR1 BCAR1 FLT1 FLT1 LOC100989777 LOC100989777 TNC TNC PDGFD PDGFD ITGA3 ITGA3 PXN PXN LAMC1 LAMC1 LAMC3 LAMC3 PIP5K1A PIP5K1A PRKCB PRKCB LAMB2 LAMB2 TNR TNR RELN RELN THBS4 THBS4 HGF HGF RAF1 RAF1 CAPN2 CAPN2 PARVG PARVG CTNNB1 CTNNB1 AKT3 AKT3 PAK2 PAK2 LAMC2 LAMC2 COL4A5 COL4A5 TLN2 TLN2 FLNC FLNC ITGA1 ITGA1 FYN FYN ARHGAP35 ARHGAP35 ITGAV ITGAV BRAF BRAF COL9A1 COL9A1 ITGA7 ITGA7 ITGA4 ITGA4 CCND2 CCND2 PARVA PARVA VAV1 VAV1 CAV1 CAV1 VTN VTN VASP VASP ARHGAP5 ARHGAP5 PAK4 PAK4 ACTN1 ACTN1 ACTG1 ACTG1 MYL12A MYL12A PDGFRB PDGFRB COL4A4 COL4A4 VAV2 VAV2 ITGB7 ITGB7 COL6A6 COL6A6 MET MET MAPK9 MAPK9 COL6A3 COL6A3 LAMB4 LAMB4 ITGB1 ITGB1 IBSP IBSP MYL7 MYL7 ROCK2 ROCK2 PDGFC PDGFC MYL5 MYL5 LAMA4 LAMA4 LOC100995377 LOC100995377 TNN TNN ITGA2B ITGA2B RAP1B RAP1B THBS2 THBS2 RAP1A RAP1A SPP1 SPP1 AKT1 AKT1 ROCK1 ROCK1 RAPGEF1 RAPGEF1 ACTN4 ACTN4 SOS2 SOS2 SRC SRC COMP COMP MYLK2 MYLK2 DOCK1 DOCK1 GSK3B GSK3B MYL9 MYL9 ITGA5 ITGA5 ITGB6 ITGB6 ENSPPAP00000037256 ENSPPAP00000037256 FN1 FN1 ERBB2 ERBB2 CAV3 CAV3 VEGFD VEGFD PPP1R12C PPP1R12C SHC4 SHC4 PIK3R1 PIK3R1 FLT4 FLT4 CAV2 CAV2 COL1A2 COL1A2 CHAD CHAD COL9A2 COL9A2 KDR KDR MYL10 MYL10 MAPK10 MAPK10 ELK1 ELK1 SHC2 SHC2 VEGFC VEGFC LOC100976973 LOC100976973 PAK6 PAK6 ITGB8 ITGB8 ITGA2 ITGA2 THBS3 THBS3 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (168 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
IGF1IlGF domain-containing protein. (196 aa)
MYL12BMyosin light chain 12B. (172 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
COL6A5Collagen type VI alpha 5 chain. (2598 aa)
ITGB4Integrin beta. (1821 aa)
THBS1Thrombospondin 1. (1173 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (803 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1270 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
VWFVon Willebrand factor. (2813 aa)
TLN1Talin 1. (2558 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
COL2A1Uncharacterized protein. (1313 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1096 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1020 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
COL6A1Collagen type VI alpha 1 chain. (1015 aa)
MYL2Myosin light chain 2. (166 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
SHC3SHC adaptor protein 3. (501 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
ZYXZyxin. (569 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
DIAPH1FH2 domain-containing protein. (507 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ILKIntegrin linked kinase. (533 aa)
COL6A2Collagen type VI alpha 2 chain. (998 aa)
MYLKMyosin light chain kinase. (1847 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (676 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
SHC1SHC adaptor protein 1. (584 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1178 aa)
FLNBFilamin B. (2633 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1026 aa)
LAMA5Laminin subunit alpha 5. (3648 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
RAC2Rac family small GTPase 2. (192 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
CDC42Uncharacterized protein. (191 aa)
COL4A3Collagen type IV alpha 3 chain. (1641 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
PARVBParvin beta. (397 aa)
COL9A3Collagen type IX alpha 3 chain. (657 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
RHOAUncharacterized protein. (206 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
RAC1Uncharacterized protein. (224 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
FLT1Uncharacterized protein. (736 aa)
LOC100989777Uncharacterized protein. (191 aa)
TNCTenascin C. (2201 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
PXNUncharacterized protein. (1087 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
LAMC3Laminin subunit gamma 3. (1559 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
LAMB2Laminin subunit beta 2. (1780 aa)
TNRTenascin R. (1360 aa)
RELNReelin. (3460 aa)
THBS4Thrombospondin 4. (870 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
PARVGParvin gamma. (331 aa)
CTNNB1Catenin beta 1. (781 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
COL4A5Collagen type IV alpha 5 chain. (1664 aa)
TLN2Talin 2. (2544 aa)
FLNCFilamin C. (2725 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
FYNTyrosine-protein kinase. (537 aa)
ARHGAP35Rho GTPase activating protein 35. (1508 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
PARVAParvin alpha. (412 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
VTNVitronectin. (478 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
PAK4P21 (RAC1) activated kinase 4. (590 aa)
ACTN1Actinin alpha 1. (914 aa)
ACTG1Actin gamma 1. (375 aa)
MYL12AMyosin light chain 12A. (177 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
COL6A6Collagen type VI alpha 6 chain. (2241 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
COL6A3Uncharacterized protein. (2527 aa)
LAMB4Laminin subunit beta 4. (1746 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
IBSPIntegrin binding sialoprotein. (316 aa)
MYL7Myosin light chain 7. (148 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MYL5Myosin light chain 5. (173 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
LOC100995377Uncharacterized protein. (557 aa)
TNNTenascin N. (1299 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
THBS2Thrombospondin 2. (1172 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
ACTN4Actinin alpha 4. (931 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
SRCTyrosine-protein kinase. (458 aa)
COMPCartilage oligomeric matrix protein. (762 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1870 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
MYL9Myosin light chain 9. (172 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1046 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ENSPPAP00000037256PIPK domain-containing protein. (572 aa)
FN1Fibronectin 1. (2477 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (707 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
CHADChondroadherin. (359 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MYL10Myosin light chain 10. (226 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ELK1ETS transcription factor ELK1. (428 aa)
SHC2Uncharacterized protein. (539 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
LOC100976973PIPK domain-containing protein. (537 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (757 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
THBS3Thrombospondin 3. (956 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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