(62 nodes) RIG-I-like receptor signaling pathway network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	IFNA17	Interferon alpha 17. (189 aa)
	IFNA14	Interferon alpha 14. (189 aa)
	IFNA6	Interferon alpha 6. (189 aa)
	LOC100972005	Uncharacterized protein. (198 aa)
	IFNA5	Interferon alpha 5. (189 aa)
	IFNA10	Interferon alpha 10. (189 aa)
	NFKBIB	ANK_REP_REGION domain-containing protein. (270 aa)
	IFNE	Interferon epsilon. (208 aa)
	IFNA8	Interferon alpha 8. (189 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	NLRX1	NLR family member X1. (975 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
	IFNA2	Interferon alpha 2. (170 aa)
	IFNW1	Interferon omega 1. (200 aa)
	MAVS	Mitochondrial antiviral signaling protein. (540 aa)
	TKFC	Triokinase and FMN cyclase. (576 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	RNF125	Ring finger protein 125. (201 aa)
	MAPK12	Mitogen-activated protein kinase. (316 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	ISG15	ISG15 ubiquitin like modifier. (165 aa)
	SIKE1	Suppressor of IKBKE 1. (211 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	STING1	Stimulator of interferon protein. (379 aa)
	ENSPPAP00000016834	Uncharacterized protein. (195 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (145 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	IFNA7	Interferon alpha 7. (189 aa)
	IFNA21	Interferon alpha 21. (189 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
	FADD	Death domain-containing protein. (144 aa)
	TRADD	TNFRSF1A associated via death domain. (311 aa)
	IRF3	Interferon regulatory factor 3. (452 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1372 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CXCL10	C-X-C motif chemokine. (96 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (456 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	OTUD5	OTU domain-containing protein. (349 aa)
	AZI2	5-azacytidine induced 2. (392 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	CASP10	ENSPPAP00000035390	ENSPPAP00000039334	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.498
ATG5	DDX58	ENSPPAP00000035390	ENSPPAP00000038038	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.987
ATG5	DHX58	ENSPPAP00000035390	ENSPPAP00000015998	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.528
ATG5	FADD	ENSPPAP00000035390	ENSPPAP00000023141	Autophagy protein 5; Involved in autophagic vesicle formation.	Death domain-containing protein.	0.872
ATG5	IFIH1	ENSPPAP00000035390	ENSPPAP00000031468	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.832
ATG5	ISG15	ENSPPAP00000035390	ENSPPAP00000014623	Autophagy protein 5; Involved in autophagic vesicle formation.	ISG15 ubiquitin like modifier.	0.400
ATG5	MAPK8	ENSPPAP00000035390	ENSPPAP00000001249	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitogen-activated protein kinase.	0.408
ATG5	MAVS	ENSPPAP00000035390	ENSPPAP00000007316	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.992
ATG5	NLRX1	ENSPPAP00000035390	ENSPPAP00000004269	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.749
ATG5	TBK1	ENSPPAP00000035390	ENSPPAP00000003649	Autophagy protein 5; Involved in autophagic vesicle formation.	TANK binding kinase 1.	0.432
ATG5	TRAF6	ENSPPAP00000035390	ENSPPAP00000040651	Autophagy protein 5; Involved in autophagic vesicle formation.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.434
AZI2	CHUK	ENSPPAP00000042276	ENSPPAP00000029712	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.551
AZI2	IKBKB	ENSPPAP00000042276	ENSPPAP00000022121	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.536
AZI2	IKBKE	ENSPPAP00000042276	ENSPPAP00000031792	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.924
AZI2	IKBKG	ENSPPAP00000042276	ENSPPAP00000004543	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.951
AZI2	IRF3	ENSPPAP00000042276	ENSPPAP00000025254	5-azacytidine induced 2.	Interferon regulatory factor 3.	0.471
AZI2	OTUD5	ENSPPAP00000042276	ENSPPAP00000040777	5-azacytidine induced 2.	OTU domain-containing protein.	0.461
AZI2	TANK	ENSPPAP00000042276	ENSPPAP00000034625	5-azacytidine induced 2.	TRAF family member associated NFKB activator.	0.935
AZI2	TBK1	ENSPPAP00000042276	ENSPPAP00000003649	5-azacytidine induced 2.	TANK binding kinase 1.	0.999
AZI2	TNF	ENSPPAP00000042276	ENSPPAP00000004174	5-azacytidine induced 2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.989