STRINGSTRING
RUNX1 RUNX1 MAPK8 MAPK8 PPP3CB PPP3CB ZAP70 ZAP70 NFKBIB NFKBIB CD3D CD3D JAK1 JAK1 IKBKG IKBKG IL6ST IL6ST IL23R IL23R LOC100979649 LOC100979649 FOS FOS MAPK1 MAPK1 IFNGR2 IFNGR2 CD3G CD3G GATA3 GATA3 IL22 IL22 RORC RORC HLA-DOB HLA-DOB IL4 IL4 SMAD4 SMAD4 LOC100993508 LOC100993508 HIF1A HIF1A PRKCQ PRKCQ IL17A IL17A NFKBIE NFKBIE IL6R IL6R STAT6 STAT6 MAPK12 MAPK12 LOC100986750 LOC100986750 AHR AHR IL2 IL2 LOC100980635 LOC100980635 TGFBR1 TGFBR1 NFATC1 NFATC1 LCK LCK TGFB1 TGFB1 CD3E CD3E HLA-DPA1 HLA-DPA1 NFKB1 NFKB1 RXRG RXRG IFNGR1 IFNGR1 RELA RELA HSP90AB1 HSP90AB1 SMAD3 SMAD3 IKBKB IKBKB CD4 CD4 SMAD2 SMAD2 IL12RB1 IL12RB1 IL2RB IL2RB IL6 IL6 MAPK11 MAPK11 HLA-DOA HLA-DOA MTOR MTOR IL27RA IL27RA IL21 IL21 MHC-DMB MHC-DMB MAPK13 MAPK13 CHUK CHUK HLA-DQA2 HLA-DQA2 IL17D IL17D MAPK9 MAPK9 RORA RORA RXRB RXRB LOC100993847 LOC100993847 TYK2 TYK2 HSP90AA1 HSP90AA1 IL1R1 IL1R1 IL17F IL17F STAT1 STAT1 STAT5B STAT5B IL2RG IL2RG IL1B IL1B NFATC2 NFATC2 STAT3 STAT3 NFATC3 NFATC3 JAK3 JAK3 IRF4 IRF4 HLA-DQB1 HLA-DQB1 HLA-DQB2 HLA-DQB2 IL21R IL21R HLA-DPB1 HLA-DPB1 IL4R IL4R NFKBIA NFKBIA HLA-DRA HLA-DRA MAPK14 MAPK14 IFNG IFNG STAT5A STAT5A RXRA RXRA PPP3CA PPP3CA MAPK10 MAPK10 CD247 CD247 IL23A IL23A RARA RARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFKBIBANK_REP_REGION domain-containing protein. (270 aa)
CD3DCD3d molecule. (171 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
IL23RInterleukin 23 receptor. (629 aa)
LOC100979649Ig-like domain-containing protein. (170 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
CD3GCD3g molecule. (182 aa)
GATA3GATA binding protein 3. (444 aa)
IL22Interleukin 22. (179 aa)
RORCRAR related orphan receptor C. (525 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (266 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC100993508Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
IL17AInterleukin 17A. (155 aa)
NFKBIENFKB inhibitor epsilon. (486 aa)
IL6RInterleukin 6 receptor. (468 aa)
STAT6Signal transducer and activator of transcription. (852 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
LOC100986750Ig-like domain-containing protein. (287 aa)
AHRUncharacterized protein. (850 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
LOC100980635Uncharacterized protein. (361 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
LCKTyrosine-protein kinase. (524 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CD3ECD3e molecule. (207 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RXRGRetinoid X receptor gamma. (473 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
HSP90AB1HATPase_c domain-containing protein. (688 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CD4CD4 molecule. (458 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (662 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
IL6Uncharacterized protein. (198 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
MHC-DMBIg-like domain-containing protein. (276 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
IL17DInterleukin 17D. (201 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RORARAR related orphan receptor A. (559 aa)
RXRBRetinoid X receptor beta. (537 aa)
LOC100993847Ig-like domain-containing protein. (270 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
HSP90AA1HATPase_c domain-containing protein. (854 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
IL17FInterleukin 17F. (163 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
IRF4Interferon regulatory factor 4. (392 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
IL21RInterleukin 21 receptor. (538 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IL4RInterleukin 4 receptor. (873 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
RXRARetinoid X receptor alpha. (472 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CD247CD247 molecule. (163 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
RARAUncharacterized protein. (609 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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