STRINGSTRING
MAPK8 MAPK8 PPP3CB PPP3CB ZAP70 ZAP70 IL10 IL10 NFKBIB NFKBIB PIK3R3 PIK3R3 CD3D CD3D TNF TNF IKBKG IKBKG FOS FOS PAK5 PAK5 MAPK1 MAPK1 VAV3 VAV3 CD3G CD3G GRAP2 GRAP2 SOS1 SOS1 IL4 IL4 PTPN6 PTPN6 MAP3K7 MAP3K7 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS PRKCQ PRKCQ NCK1 NCK1 NFKBIE NFKBIE ENSPPAP00000011278 ENSPPAP00000011278 MAP2K2 MAP2K2 MAPK12 MAPK12 TEC TEC IL2 IL2 NFATC1 NFATC1 CDC42 CDC42 LCK LCK RHOA RHOA ITK ITK PIK3CB PIK3CB CD3E CD3E NFKB1 NFKB1 CBLB CBLB RELA RELA DLG1 DLG1 IKBKB IKBKB PTPRC PTPRC CD4 CD4 CD28 CD28 CARD11 CARD11 RAF1 RAF1 AKT3 AKT3 PAK2 PAK2 LCP2 LCP2 FYN FYN MAPK11 MAPK11 MAP3K8 MAP3K8 VAV1 VAV1 CDK4 CDK4 ICOS ICOS PAK4 PAK4 MALT1 MALT1 VAV2 VAV2 NCK2 NCK2 MAPK13 MAPK13 CHUK CHUK NRAS NRAS MAPK9 MAPK9 MAP2K7 MAP2K7 RASGRP1 RASGRP1 BCL10 BCL10 AKT1 AKT1 SOS2 SOS2 NFATC2 NFATC2 NFATC3 NFATC3 MAP3K14 MAP3K14 GSK3B GSK3B CSF2 CSF2 CD8B CD8B CTLA4 CTLA4 NFKBIA NFKBIA MAPK14 MAPK14 IFNG IFNG PIK3R1 PIK3R1 CD40LG CD40LG PPP3CA PPP3CA MAPK10 MAPK10 CD247 CD247 PAK6 PAK6 IL5 IL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
IL10Interleukin 10. (178 aa)
NFKBIBANK_REP_REGION domain-containing protein. (270 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
CD3DCD3d molecule. (171 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
CD3GCD3g molecule. (182 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
NCK1Cytoplasmic protein. (377 aa)
NFKBIENFKB inhibitor epsilon. (486 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
TECTyrosine-protein kinase. (631 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
CDC42Uncharacterized protein. (191 aa)
LCKTyrosine-protein kinase. (524 aa)
RHOAUncharacterized protein. (206 aa)
ITKTyrosine-protein kinase. (620 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CD3ECD3e molecule. (207 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CBLBCbl proto-oncogene B. (982 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
CD4CD4 molecule. (458 aa)
CD28CD28 molecule. (220 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ICOSInducible T cell costimulator. (199 aa)
PAK4P21 (RAC1) activated kinase 4. (590 aa)
MALT1MALT1 paracaspase. (786 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
NCK2Cytoplasmic protein. (380 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
RASGRP1RAS guanyl releasing protein 1. (843 aa)
BCL10CARD domain-containing protein. (316 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CSF2Colony stimulating factor 2. (144 aa)
CD8BIg-like domain-containing protein. (243 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CD247CD247 molecule. (163 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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