STRINGSTRING
MAPK8 MAPK8 PIK3R3 PIK3R3 TNF TNF MAPK1 MAPK1 VAV3 VAV3 FCER1G FCER1G SOS1 SOS1 IL4 IL4 ENSPPAP00000008696 ENSPPAP00000008696 FCER1A FCER1A MAP2K4 MAP2K4 ENSPPAP00000009755 ENSPPAP00000009755 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS PLA2G4E PLA2G4E ENSPPAP00000011278 ENSPPAP00000011278 MAP2K2 MAP2K2 MAPK12 MAPK12 GAB2 GAB2 LYN LYN IL13 IL13 INPP5D INPP5D RAC2 RAC2 PRKCA PRKCA PIK3CB PIK3CB RAC1 RAC1 LOC100989777 LOC100989777 ALOX5AP ALOX5AP PLA2G4F PLA2G4F IL3 IL3 RAF1 RAF1 AKT3 AKT3 LCP2 LCP2 FYN FYN MAPK11 MAPK11 VAV1 VAV1 MAP2K6 MAP2K6 VAV2 VAV2 SYK SYK MAPK13 MAPK13 NRAS NRAS MAPK9 MAPK9 BTK BTK MAP2K7 MAP2K7 PLCG2 PLCG2 PLA2G4D PLA2G4D AKT1 AKT1 LOC103785316 LOC103785316 SOS2 SOS2 ALOX5 ALOX5 MS4A2 MS4A2 CSF2 CSF2 MAPK14 MAPK14 PIK3R1 PIK3R1 MAPK10 MAPK10 PLA2G4A PLA2G4A PLA2G4C PLA2G4C IL5 IL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
FCER1GUncharacterized protein. (112 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ENSPPAP00000008696Ig-like domain-containing protein. (147 aa)
FCER1AFc fragment of IgE receptor Ia. (260 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
ENSPPAP00000009755Ig-like domain-containing protein. (116 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLA2G4EPhospholipase A2. (868 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
LYNTyrosine-protein kinase. (526 aa)
IL13Interleukin 13. (146 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
RAC2Rac family small GTPase 2. (192 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RAC1Uncharacterized protein. (224 aa)
LOC100989777Uncharacterized protein. (191 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (218 aa)
PLA2G4FPhospholipase A2. (849 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (154 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
SYKTyrosine-protein kinase. (635 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BTKTyrosine-protein kinase. (693 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PLA2G4DPhospholipase A2. (818 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
MS4A2Membrane spanning 4-domains A2. (244 aa)
CSF2Colony stimulating factor 2. (144 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PLA2G4APhospholipase A2. (749 aa)
PLA2G4CPhospholipase A2 group IVC. (529 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.