STRINGSTRING
DNM2 DNM2 WASF1 WASF1 RPS6KB2 RPS6KB2 CFL2 CFL2 PIP5K1B PIP5K1B PIK3R3 PIK3R3 ASAP2 ASAP2 CRKL CRKL SPHK1 SPHK1 MAPK1 MAPK1 VAV3 VAV3 LOC100979343 LOC100979343 ENSPPAP00000008696 ENSPPAP00000008696 ENSPPAP00000009755 ENSPPAP00000009755 PIK3R2 PIK3R2 PIK3CA PIK3CA RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 AKT2 AKT2 PLA2G4E PLA2G4E ARPC3 ARPC3 ARPC1B ARPC1B GAB2 GAB2 PIP5K1C PIP5K1C CRK CRK LYN LYN FCGR2A FCGR2A INPP5D INPP5D RAC2 RAC2 CDC42 CDC42 ASAP3 ASAP3 ARPC4 ARPC4 PRKCA PRKCA NCF1 NCF1 PIK3CB PIK3CB ARPC1A ARPC1A WAS WAS RAC1 RAC1 PRKCE PRKCE GSN GSN ARF6 ARF6 LOC100989777 LOC100989777 PRKCD PRKCD MYO10 MYO10 ARPC5L ARPC5L SPHK2 SPHK2 PLA2G4F PLA2G4F PIP5K1A PIP5K1A PTPRC PTPRC PRKCB PRKCB RAF1 RAF1 AKT3 AKT3 WASF3 WASF3 ARPC2 ARPC2 VAV1 VAV1 PLD2 PLD2 VASP VASP VAV2 VAV2 SYK SYK HCK HCK LOC100984838 LOC100984838 ARPC5 ARPC5 CCDC125 CCDC125 PLCG2 PLCG2 PLA2G4D PLA2G4D FCGR1A FCGR1A LIMK2 LIMK2 AKT1 AKT1 LIMK1 LIMK1 LOC103785316 LOC103785316 DOCK1 DOCK1 ENSPPAP00000037256 ENSPPAP00000037256 CFL1 CFL1 WASF2 WASF2 PIK3R1 PIK3R1 ASAP1 ASAP1 AMPH AMPH PLPP2 PLPP2 PLA2G4A PLA2G4A LOC100976973 LOC100976973 PLA2G4C PLA2G4C PLPP3 PLPP3 SCIN SCIN INPPL1 INPPL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (785 aa)
WASF1WASP family member 1. (559 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (988 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SPHK1Sphingosine kinase 1. (470 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
LOC100979343Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (176 aa)
ENSPPAP00000008696Ig-like domain-containing protein. (147 aa)
ENSPPAP00000009755Ig-like domain-containing protein. (116 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLA2G4EPhospholipase A2. (868 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (158 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (676 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
LYNTyrosine-protein kinase. (526 aa)
FCGR2AFc fragment of IgG receptor IIa. (316 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
RAC2Rac family small GTPase 2. (192 aa)
CDC42Uncharacterized protein. (191 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (905 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (173 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
WASWASP actin nucleation promoting factor. (502 aa)
RAC1Uncharacterized protein. (224 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
GSNGelsolin. (784 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LOC100989777Uncharacterized protein. (191 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
SPHK2Sphingosine kinase 2. (663 aa)
PLA2G4FPhospholipase A2. (849 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WASF3WASP family member 3. (502 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
PLD2Phospholipase. (915 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
SYKTyrosine-protein kinase. (635 aa)
HCKTyrosine-protein kinase. (526 aa)
LOC100984838Uncharacterized protein. (334 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
CCDC125Coiled-coil domain containing 125. (486 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PLA2G4DPhospholipase A2. (818 aa)
FCGR1AUncharacterized protein. (368 aa)
LIMK2LIM domain kinase 2. (684 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
LIMK1LIM domain kinase 1. (677 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1870 aa)
ENSPPAP00000037256PIPK domain-containing protein. (572 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (204 aa)
WASF2WASP family member 2. (489 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1129 aa)
AMPHAmphiphysin. (695 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC100976973PIPK domain-containing protein. (537 aa)
PLA2G4CPhospholipase A2 group IVC. (529 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
SCINScinderin. (715 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1253 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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