STRINGSTRING
TRAF2 TRAF2 BIRC2 BIRC2 MAPK8 MAPK8 CCL20 CCL20 PIK3R3 PIK3R3 LIF LIF RIPK3 RIPK3 SOCS3 SOCS3 TNF TNF TNFRSF1A TNFRSF1A IKBKG IKBKG FOS FOS CREB3L4 CREB3L4 MAPK1 MAPK1 JUNB JUNB CFLAR CFLAR ATF2 ATF2 TAB1 TAB1 MAP3K7 MAP3K7 MAP2K4 MAP2K4 TRAF3 TRAF3 PIK3R2 PIK3R2 PIK3CA PIK3CA MAP2K1 MAP2K1 AKT2 AKT2 RPS6KA4 RPS6KA4 CREB3L1 CREB3L1 BIRC3 BIRC3 MAPK12 MAPK12 CASP3 CASP3 EDN1 EDN1 TAB2 TAB2 TAB3 TAB3 CXCL1 CXCL1 CREB5 CREB5 TRAF5 TRAF5 PIK3CB PIK3CB NFKB1 NFKB1 RELA RELA CCL2 CCL2 ATF6B ATF6B TNFRSF1B TNFRSF1B ICAM1 ICAM1 IKBKB IKBKB CREB3 CREB3 TNFAIP3 TNFAIP3 JAG1 JAG1 CREB3L3 CREB3L3 CXCL5 CXCL5 FADD FADD AKT3 AKT3 TRADD TRADD IL6 IL6 FAS FAS IL18R1 IL18R1 MAPK11 MAPK11 MMP3 MMP3 IRF1 IRF1 CX3CL1 CX3CL1 MAP3K8 MAP3K8 CASP7 CASP7 MMP14 MMP14 CXCL6 CXCL6 MAP2K6 MAP2K6 PGAM5 PGAM5 MAPK13 MAPK13 CHUK CHUK MAPK9 MAPK9 BCL3 BCL3 RPS6KA5 RPS6KA5 CXCL10 CXCL10 MMP9 MMP9 CXCL2 CXCL2 DAB2IP DAB2IP MAP2K7 MAP2K7 LTA LTA ATF4 ATF4 DNM1L DNM1L IL1B IL1B AKT1 AKT1 MAP3K5 MAP3K5 SELE SELE MAP3K14 MAP3K14 CSF2 CSF2 VEGFD VEGFD BAG4 BAG4 TRAF1 TRAF1 NFKBIA NFKBIA MAPK14 MAPK14 PIK3R1 PIK3R1 MLKL MLKL CASP10 CASP10 CSF1 CSF1 CREB3L2 CREB3L2 MAPK10 MAPK10 NOD2 NOD2 PTGS2 PTGS2 VEGFC VEGFC IL15 IL15 CCL5 CCL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CCL20C-C motif chemokine. (96 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
EDN1Endothelin 1. (212 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
CXCL1C-X-C motif chemokine. (107 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CCL2C-C motif chemokine. (99 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
TNFRSF1BTNF receptor superfamily member 1B. (461 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
TNFAIP3TNF alpha induced protein 3. (784 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
CXCL5C-X-C motif chemokine. (114 aa)
FADDDeath domain-containing protein. (144 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IL6Uncharacterized protein. (198 aa)
FASFas cell surface death receptor. (335 aa)
IL18R1Uncharacterized protein. (440 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
IRF1Interferon regulatory factor. (325 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CXCL6C-X-C motif chemokine. (114 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
PGAM5Uncharacterized protein. (140 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BCL3BCL3 transcription coactivator. (383 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
CXCL10C-X-C motif chemokine. (96 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
CXCL2C-X-C motif chemokine. (107 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
ATF4Activating transcription factor 4. (340 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
SELESelectin E. (612 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
CSF2Colony stimulating factor 2. (144 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
BAG4BCL2 associated athanogene 4. (460 aa)
TRAF1TNF receptor-associated factor. (416 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CCL5C-C motif chemokine. (91 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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