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GUCY1B1 GUCY1B1 PRKACG PRKACG PRKACA PRKACA KCNJ3 KCNJ3 ADCY9 ADCY9 FOS FOS PLCB1 PLCB1 CALML5 CALML5 GNG2 GNG2 PLCB4 PLCB4 MAPK1 MAPK1 CALML3 CALML3 GRIA3 GRIA3 CACNA1I CACNA1I ADCY7 ADCY7 GRIN2B GRIN2B GRIA4 GRIA4 GNGT1 GNGT1 MTNR1A MTNR1A GNGT2 GNGT2 PER3 PER3 CACNA1G CACNA1G GNAQ GNAQ GRIA1 GRIA1 LOC100980358 LOC100980358 GNB2 GNB2 GNAI1 GNAI1 MTNR1B MTNR1B ADCY6 ADCY6 GRIN1 GRIN1 CACNA1C CACNA1C RYR3 RYR3 C1H1orf226 C1H1orf226 PRKCA PRKCA GNAI2 GNAI2 PRKACB PRKACB ADCYAP1 ADCYAP1 GNG3 GNG3 KCNJ6 KCNJ6 GNAS GNAS RYR1 RYR1 GNAS-2 GNAS-2 CALML4 CALML4 GNG8 GNG8 GNG4 GNG4 ADCY10 ADCY10 PRKG1 PRKG1 GRIN2A GRIN2A CACNA1H CACNA1H PRKCB PRKCB GRIN2D GRIN2D KCNJ9 KCNJ9 ADCY2 ADCY2 LOC100989438 LOC100989438 KCNJ5 KCNJ5 GUCY1A1 GUCY1A1 ADCY5 ADCY5 RASD1 RASD1 GNG7 GNG7 ADCY8 ADCY8 CALM3 CALM3 GNB1 GNB1 RPS6KA5 RPS6KA5 GRIA2 GRIA2 GNAI3 GNAI3 ADCY3 ADCY3 ADCY4 ADCY4 ADCY1 ADCY1 GNB5 GNB5 PLCB2 PLCB2 CALML6 CALML6 PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 PER1 PER1 PRKG2 PRKG2 GNG11 GNG11 GNAO1 GNAO1 CAMK2A CAMK2A GNB3 GNB3 PER2 PER2 CACNA1D CACNA1D GNB4 GNB4 NOS1 NOS1 RYR2 RYR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (644 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
KCNJ3Uncharacterized protein. (308 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2175 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (352 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PER3Period circadian regulator 3. (1211 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2364 aa)
GNAQG protein subunit alpha q. (313 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
LOC100980358Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
GNB2G protein subunit beta 2. (340 aa)
GNAI1G protein subunit alpha i1. (323 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
RYR3Ryanodine receptor 3. (4835 aa)
C1H1orf226Uncharacterized protein. (267 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
GNASGNAS complex locus. (1043 aa)
RYR1Ryanodine receptor 1. (4924 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY10Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1610 aa)
PRKG1cGMP-dependent protein kinase. (671 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2328 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
GRIN2DUncharacterized protein. (806 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
LOC100989438Uncharacterized protein. (873 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
RASD1Ras related dexamethasone induced 1. (269 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
GNB1G protein subunit beta 1. (340 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
GNB5G protein subunit beta 5. (395 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
PER1Period circadian regulator 1. (1290 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GNB3G protein subunit beta 3. (340 aa)
PER2Period circadian regulator 2. (1255 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNB4G protein subunit beta 4. (340 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa)
RYR2Ryanodine receptor 2. (4948 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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