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CHRM2 CHRM2 CHRM5 CHRM5 KCNJ2 KCNJ2 PIK3R3 PIK3R3 PRKACG PRKACG PRKACA PRKACA KCNJ3 KCNJ3 ADCY9 ADCY9 CHRM1 CHRM1 FOS FOS CREB3L4 CREB3L4 KCNJ4 KCNJ4 PLCB1 PLCB1 GNG2 GNG2 PLCB4 PLCB4 MAPK1 MAPK1 CHRM4 CHRM4 ADCY7 ADCY7 CHRNA7 CHRNA7 CACNA1F CACNA1F GNGT1 GNGT1 ITPR2 ITPR2 GNGT2 GNGT2 PIK3R2 PIK3R2 PIK3CA PIK3CA GNAQ GNAQ MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS SLC5A7 SLC5A7 KCNJ14 KCNJ14 CHRNB4 CHRNB4 CREB3L1 CREB3L1 GNB2 GNB2 GNAI1 GNAI1 CREB5 CREB5 ADCY6 ADCY6 CACNA1C CACNA1C PRKCA PRKCA PIK3CB PIK3CB GNAI2 GNAI2 CHRNB2 CHRNB2 PRKACB PRKACB BCL2 BCL2 SLC18A3 SLC18A3 GNG3 GNG3 KCNJ6 KCNJ6 GNG8 GNG8 GNG4 GNG4 PIK3R6 PIK3R6 CREB3 CREB3 PRKCB PRKCB CREB3L3 CREB3L3 ACHE ACHE ADCY2 ADCY2 KCNQ1 KCNQ1 CHAT CHAT AKT3 AKT3 FYN FYN ADCY5 ADCY5 PIK3R5 PIK3R5 GNG7 GNG7 KCNQ3 KCNQ3 CHRNA6 CHRNA6 ADCY8 ADCY8 CHRNA4 CHRNA4 NRAS NRAS GNB1 GNB1 GNAI3 GNAI3 ADCY3 ADCY3 ADCY4 ADCY4 GNA11 GNA11 ATF4 ATF4 ADCY1 ADCY1 GNB5 GNB5 PLCB2 PLCB2 AKT1 AKT1 CACNA1S CACNA1S PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 GNG11 GNG11 KCNQ5 KCNQ5 KCNQ4 KCNQ4 CAMK4 CAMK4 CACNA1B CACNA1B GNAO1 GNAO1 PIK3R1 PIK3R1 CAMK2A CAMK2A CREB3L2 CREB3L2 GNB3 GNB3 PIK3CG PIK3CG CACNA1D CACNA1D GNB4 GNB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
KCNJ3Uncharacterized protein. (308 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CHRNA7Uncharacterized protein. (511 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
GNAQG protein subunit alpha q. (313 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (498 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GNB2G protein subunit beta 2. (340 aa)
GNAI1G protein subunit alpha i1. (323 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (557 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (740 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FYNTyrosine-protein kinase. (537 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (856 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (612 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNB1G protein subunit beta 1. (340 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNA11G protein subunit alpha 11. (319 aa)
ATF4Activating transcription factor 4. (340 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
GNB5G protein subunit beta 5. (395 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (951 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (624 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
CACNA1BUncharacterized protein. (491 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GNB3G protein subunit beta 3. (340 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNB4G protein subunit beta 4. (340 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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