97 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HTR2A	5-hydroxytryptamine receptor 2A. (471 aa)
	HTR1E	5-hydroxytryptamine receptor 1E. (365 aa)
	HTR6	5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	TRPC1	Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
	HTR1F	5-hydroxytryptamine receptor 1F. (366 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	ALOX12B	Arachidonate 12-lipoxygenase, 12R type. (693 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	KCNJ3	Uncharacterized protein. (308 aa)
	HTR1B	5-hydroxytryptamine receptor 1B. (390 aa)
	HTR1D	5-hydroxytryptamine receptor 1D. (377 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (481 aa)
	SLC18A2	Solute carrier family 18 member A2. (514 aa)
	HTR1A	5-hydroxytryptamine receptor 1A. (422 aa)
	LOC100988273	Uncharacterized protein. (289 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	PTGS1	Prostaglandin-endoperoxide synthase 1. (599 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
	GNGT1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	HTR3B	5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
	LOC100990391	G_PROTEIN_RECEP_F1_2 domain-containing protein. (359 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PLA2G4E	Phospholipase A2. (868 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (663 aa)
	DDC	Dopa decarboxylase. (489 aa)
	ALOX15	Arachidonate 15-lipoxygenase. (662 aa)
	GNB2	G protein subunit beta 2. (340 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	GNAI1	G protein subunit alpha i1. (323 aa)
	TPH2	Tryptophan hydroxylase 2. (490 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (423 aa)
	GNAS	GNAS complex locus. (1043 aa)
	MAOA	Amine oxidase. (527 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	MAOB	Amine oxidase. (520 aa)
	PLA2G4F	Phospholipase A2. (849 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	CYP4X1	Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (509 aa)
	KCND2	Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (393 aa)
	CYP2C19	Cytochrome P450 family 2 subfamily C member 19; Belongs to the cytochrome P450 family. (490 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (419 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	GNB1	G protein subunit beta 1. (340 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	SLC18A1	Solute carrier family 18 member A1. (508 aa)
	TPH1	Tryptophan hydroxylase 1. (444 aa)
	HTR3C	5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
	HTR7	5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (480 aa)
	GNB5	G protein subunit beta 5. (395 aa)
	PLA2G4D	Phospholipase A2. (818 aa)
	GABRB3	Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (396 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (676 aa)
	HTR5A	5-hydroxytryptamine receptor 5A. (357 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
	LOC100967379	Uncharacterized protein. (393 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
	HTR4	5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	GNG11	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	GABRB1	Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
	CYP2J2	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
	CACNA1B	Uncharacterized protein. (491 aa)
	GNAO1	G protein subunit alpha o1. (354 aa)
	HTR2C	5-hydroxytryptamine receptor 2C. (458 aa)
	GNB3	G protein subunit beta 3. (340 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (905 aa)
	PLA2G4C	Phospholipase A2 group IVC. (529 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
	GNB4	G protein subunit beta 4. (340 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CACNA1C	ENSPPAP00000025948	ENSPPAP00000016346	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.568
ADCY5	GNAI1	ENSPPAP00000025948	ENSPPAP00000014368	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.945
ADCY5	GNAI2	ENSPPAP00000025948	ENSPPAP00000017425	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.942
ADCY5	GNAI3	ENSPPAP00000025948	ENSPPAP00000030486	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.942
ADCY5	GNAO1	ENSPPAP00000025948	ENSPPAP00000037906	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha o1.	0.969
ADCY5	GNAS	ENSPPAP00000025948	ENSPPAP00000019582	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.980
ADCY5	GNAS-2	ENSPPAP00000025948	ENSPPAP00000020165	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.902
ADCY5	GNB1	ENSPPAP00000025948	ENSPPAP00000030100	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 1.	0.936
ADCY5	GNB2	ENSPPAP00000025948	ENSPPAP00000013095	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 2.	0.934
ADCY5	GNB3	ENSPPAP00000025948	ENSPPAP00000040549	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 3.	0.935
ADCY5	GNB4	ENSPPAP00000025948	ENSPPAP00000042528	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 4.	0.934
ADCY5	GNB5	ENSPPAP00000025948	ENSPPAP00000033565	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 5.	0.948
ADCY5	GNG11	ENSPPAP00000025948	ENSPPAP00000036374	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.942
ADCY5	GNG2	ENSPPAP00000025948	ENSPPAP00000005998	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.959
ADCY5	GNG3	ENSPPAP00000025948	ENSPPAP00000017979	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.940
ADCY5	GNG4	ENSPPAP00000025948	ENSPPAP00000020731	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.943
ADCY5	GNG7	ENSPPAP00000025948	ENSPPAP00000027347	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.945
ADCY5	GNG8	ENSPPAP00000025948	ENSPPAP00000020685	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.937
ADCY5	GNGT1	ENSPPAP00000025948	ENSPPAP00000008795	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.934
ADCY5	GNGT2	ENSPPAP00000025948	ENSPPAP00000009602	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.945