STRINGSTRING
MAPK8 MAPK8 PPP3CB PPP3CB PRKACG PRKACG ARNTL ARNTL PRKACA PRKACA KCNJ3 KCNJ3 DRD1 DRD1 PPP2R5A PPP2R5A PPP2R1A PPP2R1A SLC18A2 SLC18A2 FOS FOS CREB3L4 CREB3L4 PPP2R2D PPP2R2D PLCB1 PLCB1 DRD5 DRD5 CALML5 CALML5 PPP2R5E PPP2R5E GNG2 GNG2 PLCB4 PLCB4 CALML3 CALML3 GRIA3 GRIA3 GRIN2B GRIN2B GRIA4 GRIA4 COMT COMT SLC6A3 SLC6A3 GNGT1 GNGT1 ATF2 ATF2 GNAL GNAL ITPR2 ITPR2 GNGT2 GNGT2 KIF5B KIF5B GNAQ GNAQ PPP1R1B PPP1R1B GRIA1 GRIA1 AKT2 AKT2 PPP2R5D PPP2R5D PPP1CB PPP1CB DDC DDC CLOCK CLOCK CREB3L1 CREB3L1 GNB2 GNB2 MAPK12 MAPK12 PPP2CA PPP2CA DRD2 DRD2 PPP1CC PPP1CC PPP2R3C PPP2R3C GNAI1 GNAI1 CREB5 CREB5 KIF5C KIF5C CACNA1C CACNA1C LOC100967430 LOC100967430 PRKCA PRKCA GNAI2 GNAI2 PRKACB PRKACB GNG3 GNG3 KCNJ6 KCNJ6 PPP2R5B PPP2R5B GNAS GNAS MAOA MAOA GNAS-2 GNAS-2 CALML4 CALML4 ATF6B ATF6B GNG8 GNG8 GNG4 GNG4 MAOB MAOB DRD3 DRD3 CREB3 CREB3 GRIN2A GRIN2A PRKCB PRKCB CREB3L3 CREB3L3 KCNJ9 KCNJ9 PPP2R2A PPP2R2A KCNJ5 KCNJ5 AKT3 AKT3 PPP2CB PPP2CB MAPK11 MAPK11 ADCY5 ADCY5 GSK3A GSK3A GNG7 GNG7 SCN1A SCN1A CALM3 CALM3 MAPK13 MAPK13 GNB1 GNB1 MAPK9 MAPK9 GRIA2 GRIA2 KIF5A KIF5A GNAI3 GNAI3 SLC18A1 SLC18A1 PPP2R3A PPP2R3A ARRB2 ARRB2 PPP2R2C PPP2R2C ATF4 ATF4 GNB5 GNB5 PLCB2 PLCB2 CALML6 CALML6 AKT1 AKT1 PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 GNG11 GNG11 GSK3B GSK3B CACNA1B CACNA1B GNAO1 GNAO1 MAPK14 MAPK14 CAMK2A CAMK2A PPP3CA PPP3CA CREB3L2 CREB3L2 MAPK10 MAPK10 GNB3 GNB3 PPP2R2B PPP2R2B CALY CALY CACNA1D CACNA1D GNB4 GNB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
KCNJ3Uncharacterized protein. (308 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (477 aa)
CALML5Calmodulin like 5. (146 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (469 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (221 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GNALUncharacterized protein. (381 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
GNAQG protein subunit alpha q. (313 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (179 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
DDCDopa decarboxylase. (489 aa)
CLOCKClock circadian regulator. (847 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GNB2G protein subunit beta 2. (340 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
PPP2CASerine/threonine-protein phosphatase. (294 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GNAI1G protein subunit alpha i1. (323 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
LOC100967430Uncharacterized protein. (291 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
GNASGNAS complex locus. (1043 aa)
MAOAAmine oxidase. (527 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAOBAmine oxidase. (520 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (463 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1974 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GNB1G protein subunit beta 1. (340 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1023 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SLC18A1Solute carrier family 18 member A1. (508 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
ARRB2Arrestin beta 2. (447 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (535 aa)
ATF4Activating transcription factor 4. (340 aa)
GNB5G protein subunit beta 5. (395 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CACNA1BUncharacterized protein. (491 aa)
GNAO1G protein subunit alpha o1. (354 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
GNB3G protein subunit beta 3. (340 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CALYCalcyon neuron specific vesicular protein. (227 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNB4G protein subunit beta 4. (340 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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