81 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	ENSPPAP00000001685	Uncharacterized protein. (91 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	CALML5	Calmodulin like 5. (146 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
	GNRH1	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PLA2G4E	Phospholipase A2. (868 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
	MAPK12	Mitogen-activated protein kinase. (316 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	CDC42	Uncharacterized protein. (191 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	GNAS	GNAS complex locus. (1043 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	CALML4	Calmodulin like 4. (196 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	LHB	Luteinizing hormone beta polypeptide. (144 aa)
	PLA2G4F	Phospholipase A2. (849 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	MAP3K2	Mitogen-activated protein kinase kinase kinase 2. (619 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (655 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	PLD2	Phospholipase. (915 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1372 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1597 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	GNA11	G protein subunit alpha 11. (319 aa)
	FSHB	Follicle stimulating hormone subunit beta. (129 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (408 aa)
	ATF4	Activating transcription factor 4. (340 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	PLA2G4D	Phospholipase A2. (818 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	CALML6	Calmodulin like 6. (181 aa)
	MMP2	Matrix metallopeptidase 2. (664 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
	SRC	Tyrosine-protein kinase. (458 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
	GNRHR	Gonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	ELK1	ETS transcription factor ELK1. (428 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	PLA2G4C	Phospholipase A2 group IVC. (529 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
	EGFR	Receptor protein-tyrosine kinase. (1201 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSPPAP00000033273	ENSPPAP00000023934	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.573
ADCY1	ADCY3	ENSPPAP00000033273	ENSPPAP00000030669	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY4	ENSPPAP00000033273	ENSPPAP00000031100	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.480
ADCY1	ADCY5	ENSPPAP00000033273	ENSPPAP00000025948	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY6	ENSPPAP00000033273	ENSPPAP00000015584	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.463
ADCY1	ADCY7	ENSPPAP00000033273	ENSPPAP00000007130	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.605
ADCY1	ADCY8	ENSPPAP00000033273	ENSPPAP00000028968	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.952
ADCY1	ADCY9	ENSPPAP00000033273	ENSPPAP00000003795	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.712
ADCY1	CALM3	ENSPPAP00000033273	ENSPPAP00000029183	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.965
ADCY1	CALML3	ENSPPAP00000033273	ENSPPAP00000006554	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.964
ADCY1	CALML4	ENSPPAP00000033273	ENSPPAP00000020274	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.955
ADCY1	CALML5	ENSPPAP00000033273	ENSPPAP00000005888	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.964
ADCY1	CALML6	ENSPPAP00000033273	ENSPPAP00000034585	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.956
ADCY1	CAMK2A	ENSPPAP00000033273	ENSPPAP00000039041	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.912
ADCY1	GNAS	ENSPPAP00000033273	ENSPPAP00000019582	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.980
ADCY1	GNAS-2	ENSPPAP00000033273	ENSPPAP00000020165	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.902
ADCY1	PLCB1	ENSPPAP00000033273	ENSPPAP00000005635	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.495
ADCY1	PRKACA	ENSPPAP00000033273	ENSPPAP00000003342	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.947
ADCY1	PRKACB	ENSPPAP00000033273	ENSPPAP00000017680	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.948
ADCY1	PRKACG	ENSPPAP00000033273	ENSPPAP00000002963	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.959