(79 nodes) Progesterone-mediated oocyte maturation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE3B	Phosphodiesterase. (1112 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	CPEB1	Cytoplasmic polyadenylation element binding protein 1. (626 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (745 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	IGF1	IlGF domain-containing protein. (196 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	STK10	Serine/threonine kinase 10. (968 aa)
	MOS	MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
	CDC23	Cell division cycle 23. (597 aa)
	PLK1	Serine/threonine-protein kinase PLK. (603 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	CCNB3	Cyclin B3; Belongs to the cyclin family. (1394 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1389 aa)
	PIK3R2	Uncharacterized protein. (663 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	MAPK12	Mitogen-activated protein kinase. (316 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	CDC16	Cell division cycle 16. (620 aa)
	GNAI1	G protein subunit alpha i1. (323 aa)
	ANAPC13	Anaphase promoting complex subunit 13. (74 aa)
	LOC100980635	Uncharacterized protein. (361 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (729 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (597 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	KIF22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (668 aa)
	HSP90AB1	HATPase_c domain-containing protein. (688 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (756 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	CDC26	Cell division cycle 26. (85 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (599 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	CDC27	Cell division cycle 27. (830 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1. (565 aa)
	SPDYA	Speedy/RINGO cell cycle regulator family member A. (313 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	CDC25B	Cell division cycle 25B. (575 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (398 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	HSP90AA1	HATPase_c domain-containing protein. (854 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1096 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	SPDYC	Speedy/RINGO cell cycle regulator family member C. (317 aa)
	ENSPPAP00000034531	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (165 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (465 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (718 aa)
	ANAPC2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
	SPDYE4	Speedy/RINGO cell cycle regulator family member E4. (237 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (474 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (433 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSPPAP00000033273	ENSPPAP00000023934	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.573
ADCY1	ADCY3	ENSPPAP00000033273	ENSPPAP00000030669	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY4	ENSPPAP00000033273	ENSPPAP00000031100	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.480
ADCY1	ADCY5	ENSPPAP00000033273	ENSPPAP00000025948	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY6	ENSPPAP00000033273	ENSPPAP00000015584	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.463
ADCY1	ADCY7	ENSPPAP00000033273	ENSPPAP00000007130	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.605
ADCY1	ADCY8	ENSPPAP00000033273	ENSPPAP00000028968	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.952
ADCY1	ADCY9	ENSPPAP00000033273	ENSPPAP00000003795	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.712
ADCY1	AKT1	ENSPPAP00000033273	ENSPPAP00000034920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.693
ADCY1	AKT2	ENSPPAP00000033273	ENSPPAP00000010803	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.693
ADCY1	AKT3	ENSPPAP00000033273	ENSPPAP00000024904	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.693
ADCY1	GNAI1	ENSPPAP00000033273	ENSPPAP00000014368	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.830
ADCY1	GNAI2	ENSPPAP00000033273	ENSPPAP00000017425	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.813
ADCY1	GNAI3	ENSPPAP00000033273	ENSPPAP00000030486	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.868
ADCY1	PDE3B	ENSPPAP00000033273	ENSPPAP00000000504	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.755
ADCY1	PRKACA	ENSPPAP00000033273	ENSPPAP00000003342	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.947
ADCY1	PRKACB	ENSPPAP00000033273	ENSPPAP00000017680	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.948
ADCY1	PRKACG	ENSPPAP00000033273	ENSPPAP00000002963	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.959
ADCY2	ADCY1	ENSPPAP00000023934	ENSPPAP00000033273	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.573
ADCY2	ADCY3	ENSPPAP00000023934	ENSPPAP00000030669	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.452