(67 nodes) Adipocytokine signaling pathway network (Pan paniscus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (739 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	NFKBIB	ANK_REP_REGION domain-containing protein. (270 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	NPY	Neuropeptide Y. (97 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IRS1	Insulin receptor substrate 1. (1242 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
	CPT1B	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
	CPT1A	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (720 aa)
	NFKBIE	NFKB inhibitor epsilon. (486 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	ACSBG2	Acyl-CoA synthetase bubblegum family member 2. (666 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	RXRG	Retinoid X receptor gamma. (473 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (749 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	ACSBG1	Acyl-CoA synthetase bubblegum family member 1. (724 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (461 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
	ADIPOR2	Adiponectin receptor 2. (386 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2458 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (809 aa)
	LEPR	Leptin receptor. (1165 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	TRADD	TNFRSF1A associated via death domain. (311 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (698 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	CAMKK2	Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
	CPT1C	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (745 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
	POMC	Proopiomelanocortin. (268 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	RXRB	Retinoid X receptor beta. (537 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (467 aa)
	IRS4	Insulin receptor substrate 4. (1194 aa)
	AGRP	Agouti related neuropeptide. (132 aa)
	ADIPOR1	Adiponectin receptor 1. (375 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	ACSL6	AMP-binding domain-containing protein. (714 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	G6PC3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (456 aa)
	RXRA	Retinoid X receptor alpha. (472 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (286 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (542 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ACSL1	ENSPPAP00000021619	ENSPPAP00000025336	Acetyl-CoA carboxylase beta.	Acyl-CoA synthetase long chain family member 1.	0.564
ACACB	ACSL3	ENSPPAP00000021619	ENSPPAP00000011182	Acetyl-CoA carboxylase beta.	Acyl-CoA synthetase long chain family member 3.	0.515
ACACB	ACSL4	ENSPPAP00000021619	ENSPPAP00000018085	Acetyl-CoA carboxylase beta.	Acyl-CoA synthetase long chain family member 4.	0.403
ACACB	CPT1A	ENSPPAP00000021619	ENSPPAP00000007066	Acetyl-CoA carboxylase beta.	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family.	0.966
ACACB	CPT1B	ENSPPAP00000021619	ENSPPAP00000005935	Acetyl-CoA carboxylase beta.	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family.	0.937
ACACB	CPT1C	ENSPPAP00000021619	ENSPPAP00000026475	Acetyl-CoA carboxylase beta.	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family.	0.935
ACACB	LEP	ENSPPAP00000021619	ENSPPAP00000025238	Acetyl-CoA carboxylase beta.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.490
ACACB	PPARA	ENSPPAP00000021619	ENSPPAP00000033410	Acetyl-CoA carboxylase beta.	Peroxisome proliferator activated receptor alpha.	0.463
ACACB	PRKAA1	ENSPPAP00000021619	ENSPPAP00000025661	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.922
ACACB	PRKAA2	ENSPPAP00000021619	ENSPPAP00000042200	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.925
ACACB	PRKAB1	ENSPPAP00000021619	ENSPPAP00000020897	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.915
ACACB	PRKAB2	ENSPPAP00000021619	ENSPPAP00000026212	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.919
ACACB	PRKAG1	ENSPPAP00000021619	ENSPPAP00000036650	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.914
ACACB	PRKAG2	ENSPPAP00000021619	ENSPPAP00000013508	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.919
ACACB	PRKAG3	ENSPPAP00000021619	ENSPPAP00000010754	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.914
ACSBG1	ACSBG2	ENSPPAP00000020151	ENSPPAP00000016460	Acyl-CoA synthetase bubblegum family member 1.	Acyl-CoA synthetase bubblegum family member 2.	0.612
ACSBG1	ACSL1	ENSPPAP00000020151	ENSPPAP00000025336	Acyl-CoA synthetase bubblegum family member 1.	Acyl-CoA synthetase long chain family member 1.	0.687
ACSBG1	ACSL3	ENSPPAP00000020151	ENSPPAP00000011182	Acyl-CoA synthetase bubblegum family member 1.	Acyl-CoA synthetase long chain family member 3.	0.770
ACSBG1	ACSL4	ENSPPAP00000020151	ENSPPAP00000018085	Acyl-CoA synthetase bubblegum family member 1.	Acyl-CoA synthetase long chain family member 4.	0.769
ACSBG1	ACSL5	ENSPPAP00000020151	ENSPPAP00000000729	Acyl-CoA synthetase bubblegum family member 1.	Acyl-CoA synthetase long chain family member 5.	0.689