STRINGSTRING
MYL6 MYL6 PPP3CB PPP3CB KCNJ2 KCNJ2 GUCY1B1 GUCY1B1 CACNB3 CACNB3 PRKACG PRKACG PRKACA PRKACA KCNJ3 KCNJ3 ADCY9 ADCY9 CACNA2D3 CACNA2D3 FOS FOS KCNJ4 KCNJ4 PLCB1 PLCB1 CALML5 CALML5 PLCB4 PLCB4 MAPK1 MAPK1 CACNG2 CACNG2 CALML3 CALML3 NFATC4 NFATC4 ADCY7 ADCY7 CACNA2D1 CACNA2D1 CACNG1 CACNG1 CACNA1F CACNA1F ITPR2 ITPR2 CACNB4 CACNB4 MYLK3 MYLK3 GNAQ GNAQ PRKAG3 PRKAG3 MAP2K1 MAP2K1 HRAS HRAS PLA2G4E PLA2G4E KCNJ14 KCNJ14 PPP1CB PPP1CB LOC100980358 LOC100980358 MAP2K2 MAP2K2 MYLK MYLK PRKAG2 PRKAG2 PPP1CC PPP1CC GNAI1 GNAI1 NPR2 NPR2 PPP1R12A PPP1R12A NFATC1 NFATC1 CACNG4 CACNG4 ADCY6 ADCY6 CACNG6 CACNG6 CACNA1C CACNA1C CACNA2D4 CACNA2D4 RHOA RHOA RYR3 RYR3 PRKCA PRKCA GNAI2 GNAI2 PRKACB PRKACB KCNJ6 KCNJ6 CACNB2 CACNB2 GNAS GNAS RYR1 RYR1 GNAS-2 GNAS-2 CALML4 CALML4 PRKAB1 PRKAB1 PIK3R6 PIK3R6 CAMK1 CAMK1 RCAN1 RCAN1 PLA2G4F PLA2G4F PRKCB PRKCB KCNJ9 KCNJ9 ADCY2 ADCY2 RAF1 RAF1 KCNJ5 KCNJ5 NPR1 NPR1 GUCY1A1 GUCY1A1 RGS2 RGS2 PRKAA1 PRKAA1 CAMKK2 CAMKK2 ADCY5 ADCY5 PIK3R5 PIK3R5 PRKAB2 PRKAB2 CD38 CD38 TRPM2 TRPM2 MAP2K5 MAP2K5 ACTG1 ACTG1 CACNG3 CACNG3 ADCY8 ADCY8 NPPA NPPA EEF2K EEF2K CALM3 CALM3 CDKN1A CDKN1A NRAS NRAS GNAI3 GNAI3 ADCY3 ADCY3 ADCY4 ADCY4 ROCK2 ROCK2 NOS3 NOS3 ADCY1 ADCY1 MAPK7 MAPK7 CACNA2D2 CACNA2D2 PLA2G4D PLA2G4D PLCB2 PLCB2 CALML6 CALML6 CACNG5 CACNG5 ROCK1 ROCK1 CACNA1S CACNA1S PLCB3 PLCB3 ITPR3 ITPR3 SRC SRC ITPR1 ITPR1 NFATC2 NFATC2 MYLK2 MYLK2 NFATC3 NFATC3 MYL9 MYL9 PRKAG1 PRKAG1 CAMK4 CAMK4 GNAO1 GNAO1 PPP1R12C PPP1R12C CAMK2A CAMK2A EEF2 EEF2 CAMK1G CAMK1G PPP3CA PPP3CA CAMK1D CAMK1D PIK3CG PIK3CG ELK1 ELK1 PTGS2 PTGS2 PLA2G4A PLA2G4A PLA2G4C PLA2G4C PRKAA2 PRKAA2 CACNA1D CACNA1D RYR2 RYR2 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL6Uncharacterized protein. (207 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (644 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (488 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
KCNJ3Uncharacterized protein. (308 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1067 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
GNAQG protein subunit alpha q. (313 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLA2G4EPhospholipase A2. (868 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
LOC100980358Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
MYLKMyosin light chain kinase. (1847 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
GNAI1G protein subunit alpha i1. (323 aa)
NPR2Guanylate cyclase. (1047 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1026 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (339 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (240 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1154 aa)
RHOAUncharacterized protein. (206 aa)
RYR3Ryanodine receptor 3. (4835 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
GNASGNAS complex locus. (1043 aa)
RYR1Ryanodine receptor 1. (4924 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
RCAN1Regulator of calcineurin 1. (273 aa)
PLA2G4FPhospholipase A2. (849 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
NPR1Guanylate cyclase. (1060 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CD38CD38 molecule. (300 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1552 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
ACTG1Actin gamma 1. (375 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
NPPANatriuretic peptide A. (153 aa)
EEF2KEukaryotic elongation factor 2 kinase. (723 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
NOS3Nitric oxide synthase 3. (997 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1126 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
SRCTyrosine-protein kinase. (458 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
MYL9Myosin light chain 9. (172 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (707 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
EEF2Eukaryotic translation elongation factor 2. (861 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (315 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ELK1ETS transcription factor ELK1. (428 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PLA2G4APhospholipase A2. (749 aa)
PLA2G4CPhospholipase A2 group IVC. (529 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
RYR2Ryanodine receptor 2. (4948 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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