STRINGSTRING
PDE3B PDE3B PFKP PFKP PPP3CB PPP3CB PPP4R3C PPP4R3C PRKACG PRKACG PRKACA PRKACA SIK2 SIK2 LDHAL6B LDHAL6B GCG GCG CREB3L4 CREB3L4 LDHAL6A LDHAL6A PLCB1 PLCB1 CALML5 CALML5 CPT1B CPT1B PLCB4 PLCB4 CALML3 CALML3 CPT1A CPT1A SIRT1 SIRT1 ATF2 ATF2 ITPR2 ITPR2 PFKL PFKL GNAQ GNAQ PGAM1 PGAM1 PRKAG3 PRKAG3 AKT2 AKT2 CREB3L1 CREB3L1 PYGM PYGM PRKAG2 PRKAG2 GCK GCK CREB5 CREB5 FOXO1 FOXO1 G6PC G6PC CRTC2 CRTC2 PRKACB PRKACB EP300 EP300 GNAS GNAS PGAM2 PGAM2 PDHA1 PDHA1 GNAS-2 GNAS-2 CALML4 CALML4 ENSPPAP00000020512 ENSPPAP00000020512 LDHB LDHB PRKAB1 PRKAB1 SLC2A1 SLC2A1 PCK2 PCK2 ACACB ACACB FBP2 FBP2 PPP4C PPP4C GCGR GCGR CREB3 CREB3 PYGB PYGB CREB3L3 CREB3L3 PPARGC1A PPARGC1A SIK1 SIK1 PHKB PHKB PRMT1 PRMT1 ADCY2 ADCY2 PHKG2 PHKG2 PYGL PYGL AKT3 AKT3 PRKAA1 PRKAA1 G6PC2 G6PC2 PRKAB2 PRKAB2 CPT1C CPT1C PHKA2 PHKA2 PFKM PFKM CALM3 CALM3 PCK1 PCK1 LDHC LDHC LOC100994201 LOC100994201 CREBBP CREBBP SLC2A2 SLC2A2 ATF4 ATF4 GYS1 GYS1 PPARA PPARA PLCB2 PLCB2 CALML6 CALML6 AKT1 AKT1 PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 G6PC3 G6PC3 PRKAG1 PRKAG1 PKM PKM ACACA ACACA LOC100994754 LOC100994754 GYS2 GYS2 PHKA1 PHKA1 CAMK2A CAMK2A PPP3CA PPP3CA CREB3L2 CREB3L2 FBP1 FBP1 PFKFB1 PFKFB1 LDHA LDHA PRKAA2 PRKAA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE3BPhosphodiesterase. (1112 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PPP4R3CProtein phosphatase 4 regulatory subunit 3C. (832 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
SIK2Salt inducible kinase 2. (926 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
GCGGlucagon. (179 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
SIRT1Sirtuin 1. (693 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (771 aa)
GNAQG protein subunit alpha q. (313 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
GCKPhosphotransferase. (463 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
FOXO1Fork-head domain-containing protein. (527 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CRTC2CREB regulated transcription coactivator 2. (701 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
EP300E1A binding protein p300. (2411 aa)
GNASGNAS complex locus. (1043 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (463 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
ENSPPAP00000020512Uncharacterized protein; Belongs to the LDH/MDH superfamily. (350 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (477 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (819 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
SIK1Uncharacterized protein. (783 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (745 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
LOC100994201L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (363 aa)
CREBBPCREB binding protein. (2414 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
ATF4Activating transcription factor 4. (340 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
LOC100994754SMK-1 domain-containing protein. (805 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1240 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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