63 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE1B	PDEase domain-containing protein. (218 aa)
	PDE3B	Phosphodiesterase. (1112 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	KCNJ2	Potassium voltage-gated channel subfamily J member 2. (427 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (644 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	CALML5	Calmodulin like 5. (146 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (485 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
	LOC100981456	Uncharacterized protein. (317 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
	ORAI1	Uncharacterized protein. (238 aa)
	ACE	Angiotensin-converting enzyme. (1223 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	LOC100980358	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	EDN1	Endothelin 1. (212 aa)
	CLCA4	Chloride channel accessory 4. (917 aa)
	GNAI1	G protein subunit alpha i1. (323 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (176 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1194 aa)
	GNAS	GNAS complex locus. (1043 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	CALML4	Calmodulin like 4. (196 aa)
	ADRB3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (374 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	NPR1	Guanylate cyclase. (1060 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	EDN3	Endothelin 3. (238 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	PDE1A	Phosphodiesterase. (572 aa)
	ADRB2	Adrenoceptor beta 2. (429 aa)
	NPPA	Natriuretic peptide A. (153 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	CLCA2	Chloride channel accessory 2. (943 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	EDN2	Endothelin 2. (178 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	CALML6	Calmodulin like 6. (181 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
	REN	Renin; Belongs to the peptidase A1 family. (406 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
	PRKG2	cGMP-dependent protein kinase. (762 aa)
	PDE3A	Phosphodiesterase. (1141 aa)
	PDE1C	Phosphodiesterase. (713 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	CLCA1	Chloride channel accessory 1. (935 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ADRB2	ENSPPAP00000010076	ENSPPAP00000027026	Angiotensin-converting enzyme.	Adrenoceptor beta 2.	0.400
ACE	AGT	ENSPPAP00000010076	ENSPPAP00000007994	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.980
ACE	AGTR1	ENSPPAP00000010076	ENSPPAP00000025730	Angiotensin-converting enzyme.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.792
ACE	CALM3	ENSPPAP00000010076	ENSPPAP00000029183	Angiotensin-converting enzyme.	Calmodulin 3; Belongs to the calmodulin family.	0.524
ACE	CALML3	ENSPPAP00000010076	ENSPPAP00000006554	Angiotensin-converting enzyme.	Calmodulin like 3; Belongs to the calmodulin family.	0.583
ACE	CALML4	ENSPPAP00000010076	ENSPPAP00000020274	Angiotensin-converting enzyme.	Calmodulin like 4.	0.584
ACE	CALML5	ENSPPAP00000010076	ENSPPAP00000005888	Angiotensin-converting enzyme.	Calmodulin like 5.	0.583
ACE	CALML6	ENSPPAP00000010076	ENSPPAP00000034585	Angiotensin-converting enzyme.	Calmodulin like 6.	0.574
ACE	EDN1	ENSPPAP00000010076	ENSPPAP00000013795	Angiotensin-converting enzyme.	Endothelin 1.	0.572
ACE	NPPA	ENSPPAP00000010076	ENSPPAP00000029117	Angiotensin-converting enzyme.	Natriuretic peptide A.	0.667
ACE	REN	ENSPPAP00000010076	ENSPPAP00000035562	Angiotensin-converting enzyme.	Renin; Belongs to the peptidase A1 family.	0.882
ADCY5	ADCY6	ENSPPAP00000025948	ENSPPAP00000015584	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.958
ADCY5	ADRB2	ENSPPAP00000025948	ENSPPAP00000027026	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adrenoceptor beta 2.	0.443
ADCY5	CACNA1C	ENSPPAP00000025948	ENSPPAP00000016346	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.568
ADCY5	CALM3	ENSPPAP00000025948	ENSPPAP00000029183	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.762
ADCY5	CALML3	ENSPPAP00000025948	ENSPPAP00000006554	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.779
ADCY5	CALML4	ENSPPAP00000025948	ENSPPAP00000020274	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.773
ADCY5	CALML5	ENSPPAP00000025948	ENSPPAP00000005888	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.779
ADCY5	CALML6	ENSPPAP00000025948	ENSPPAP00000034585	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.773
ADCY5	GNAI1	ENSPPAP00000025948	ENSPPAP00000014368	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.945