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MC2R MC2R STAR STAR PRKACG PRKACG PRKACA PRKACA ADCY9 ADCY9 CREB3L4 CREB3L4 PLCB1 PLCB1 CALML5 CALML5 PLCB4 PLCB4 CALML3 CALML3 CACNA1I CACNA1I ADCY7 ADCY7 DAGLA DAGLA LDLR LDLR AGT AGT CACNA1F CACNA1F ATF2 ATF2 ITPR2 ITPR2 ORAI1 ORAI1 CACNA1G CACNA1G ATP2B3 ATP2B3 GNAQ GNAQ LOC100990187 LOC100990187 ATP1A4 ATP1A4 HSD3B1 HSD3B1 CREB3L1 CREB3L1 PRKD3 PRKD3 CREB5 CREB5 ADCY6 ADCY6 CACNA1C CACNA1C PRKCA PRKCA NR4A2 NR4A2 PRKACB PRKACB PRKCE PRKCE GNAS GNAS GNAS-2 GNAS-2 CALML4 CALML4 ATF6B ATF6B CYP11A1 CYP11A1 CAMK1 CAMK1 CREB3 CREB3 CACNA1H CACNA1H ATP1A2 ATP1A2 PRKCB PRKCB CREB3L3 CREB3L3 ADCY2 ADCY2 KCNJ5 KCNJ5 NR4A1 NR4A1 NPR1 NPR1 CYP11B2 CYP11B2 ATP1B2 ATP1B2 AGTR1 AGTR1 ADCY5 ADCY5 ATP1B1 ATP1B1 PRKD1 PRKD1 ADCY8 ADCY8 PDE2A PDE2A NPPA NPPA CALM3 CALM3 POMC POMC ADCY3 ADCY3 ADCY4 ADCY4 ATF1 ATF1 GNA11 GNA11 ATP1B3 ATP1B3 HSD3B2 HSD3B2 ATF4 ATF4 ADCY1 ADCY1 ATP1A1 ATP1A1 PLCB2 PLCB2 ATP1B4 ATP1B4 CALML6 CALML6 CACNA1S CACNA1S KCNK3 KCNK3 PLCB3 PLCB3 ITPR3 ITPR3 ITPR1 ITPR1 ATP2B4 ATP2B4 CAMK4 CAMK4 KCNK9 KCNK9 CAMK2A CAMK2A LIPE LIPE CAMK1G CAMK1G CREB3L2 CREB3L2 CAMK1D CAMK1D CACNA1D CACNA1D ATP2B1 ATP2B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MC2RMelanocortin 2 receptor. (297 aa)
STARSteroidogenic acute regulatory protein. (230 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2175 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
DAGLADiacylglycerol lipase alpha. (1042 aa)
LDLRLow density lipoprotein receptor. (849 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
ORAI1Uncharacterized protein. (238 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2364 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
GNAQG protein subunit alpha q. (313 aa)
LOC1009901873Beta_HSD domain-containing protein. (448 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
GNASGNAS complex locus. (1043 aa)
GNAS-2Uncharacterized protein. (245 aa)
CALML4Calmodulin like 4. (196 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2328 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
NPR1Guanylate cyclase. (1060 aa)
CYP11B2Cytochrome P450 family 11 subfamily B member 2; Belongs to the cytochrome P450 family. (429 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (267 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PDE2APhosphodiesterase. (941 aa)
NPPANatriuretic peptide A. (153 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
POMCProopiomelanocortin. (268 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATF1Activating transcription factor 1. (270 aa)
GNA11G protein subunit alpha 11. (319 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (242 aa)
HSD3B2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (372 aa)
ATF4Activating transcription factor 4. (340 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CALML6Calmodulin like 6. (181 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
KCNK3Potassium channel subfamily K member. (378 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
KCNK9Potassium channel subfamily K member. (375 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
LIPELipase E, hormone sensitive type. (1076 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (315 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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