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COL1A1 COL1A1 COL4A6 COL4A6 MAPK8 MAPK8 PIK3R3 PIK3R3 RXFP4 RXFP4 PRKACG PRKACG RXFP3 RXFP3 PRKACA PRKACA ADCY9 ADCY9 FOS FOS CREB3L4 CREB3L4 RLN3 RLN3 PLCB1 PLCB1 GNG2 GNG2 PLCB4 PLCB4 MAPK1 MAPK1 INSL5 INSL5 RLN2 RLN2 COL4A1 COL4A1 ADCY7 ADCY7 SOS1 SOS1 EDNRB EDNRB GNGT1 GNGT1 ATF2 ATF2 GNGT2 GNGT2 MAP2K4 MAP2K4 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA MMP13 MMP13 SHC3 SHC3 MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS MAP2K2 MAP2K2 CREB3L1 CREB3L1 GNB2 GNB2 MAPK12 MAPK12 RLN1 RLN1 EDN1 EDN1 GNAI1 GNAI1 SHC1 SHC1 CREB5 CREB5 TGFBR1 TGFBR1 ADCY6 ADCY6 RXFP2 RXFP2 COL4A3 COL4A3 COL4A2 COL4A2 TGFB1 TGFB1 PRKCA PRKCA COL3A1 COL3A1 PIK3CB PIK3CB GNAI2 GNAI2 PRKACB PRKACB NFKB1 NFKB1 GNG3 GNG3 RELA RELA GNAS GNAS NOS2 NOS2 GNAS-2 GNAS-2 ATF6B ATF6B GNG8 GNG8 GNG4 GNG4 CREB3 CREB3 CREB3L3 CREB3L3 ADCY2 ADCY2 RAF1 RAF1 SMAD2 SMAD2 AKT3 AKT3 COL4A5 COL4A5 MAPK11 MAPK11 ADCY5 ADCY5 GNG7 GNG7 ADCY8 ADCY8 COL4A4 COL4A4 MAPK13 MAPK13 NRAS NRAS GNB1 GNB1 MAPK9 MAPK9 GNAI3 GNAI3 ADCY3 ADCY3 ADCY4 ADCY4 MMP9 MMP9 MAP2K7 MAP2K7 NOS3 NOS3 ARRB2 ARRB2 ATF4 ATF4 ADCY1 ADCY1 GNB5 GNB5 PLCB2 PLCB2 MMP2 MMP2 AKT1 AKT1 PLCB3 PLCB3 SOS2 SOS2 SRC SRC MMP1 MMP1 GNG11 GNG11 GNA15 GNA15 VEGFD VEGFD GNAO1 GNAO1 NFKBIA NFKBIA MAPK14 MAPK14 SHC4 SHC4 PIK3R1 PIK3R1 COL1A2 COL1A2 RXFP1 RXFP1 PRKCZ PRKCZ CREB3L2 CREB3L2 MAPK10 MAPK10 GNB3 GNB3 SHC2 SHC2 VEGFC VEGFC GNB4 GNB4 NOS1 NOS1 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL1A1Collagen type I alpha 1 chain. (1463 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
RXFP4Relaxin family peptide/INSL5 receptor 4. (374 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
RXFP3Relaxin family peptide receptor 3. (469 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
RLN3Relaxin 3. (142 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
INSL5Insulin like 5. (135 aa)
RLN2Relaxin 2. (185 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MMP13Matrix metallopeptidase 13. (503 aa)
SHC3SHC adaptor protein 3. (501 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GNB2G protein subunit beta 2. (340 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
RLN1Relaxin 1. (180 aa)
EDN1Endothelin 1. (212 aa)
GNAI1G protein subunit alpha i1. (323 aa)
SHC1SHC adaptor protein 1. (584 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
RXFP2Relaxin family peptide receptor 2. (744 aa)
COL4A3Collagen type IV alpha 3 chain. (1641 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
GNASGNAS complex locus. (1043 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
GNAS-2Uncharacterized protein. (245 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
COL4A5Collagen type IV alpha 5 chain. (1664 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNB1G protein subunit beta 1. (340 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
NOS3Nitric oxide synthase 3. (997 aa)
ARRB2Arrestin beta 2. (447 aa)
ATF4Activating transcription factor 4. (340 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
GNB5G protein subunit beta 5. (395 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
MMP2Matrix metallopeptidase 2. (664 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
SRCTyrosine-protein kinase. (458 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNA15G protein subunit alpha 15. (374 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GNAO1G protein subunit alpha o1. (354 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
RXFP1Relaxin family peptide receptor 1. (779 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
GNB3G protein subunit beta 3. (340 aa)
SHC2Uncharacterized protein. (539 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
GNB4G protein subunit beta 4. (340 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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