(101 nodes) Parathyroid hormone synthesis, secretion and action network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000000881	NAC-A/B domain-containing protein. (136 aa)
	NACA2	Nascent polypeptide associated complex subunit alpha 2. (215 aa)
	NACA	Nascent polypeptide associated complex subunit alpha. (923 aa)
	MMP16	Matrix metallopeptidase 16. (609 aa)
	GNA13	Uncharacterized protein. (282 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (395 aa)
	MAFB	MAF bZIP transcription factor B. (323 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	GATA3	GATA binding protein 3. (444 aa)
	SLC34A3	Solute carrier family 34 member 3. (600 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	LRP5	LDL receptor related protein 5. (1839 aa)
	PTHLH	Parathyroid hormone like hormone. (208 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
	MMP13	Matrix metallopeptidase 13. (503 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	MMP24	Matrix metallopeptidase 24. (612 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1529 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	MMP17	Matrix metallopeptidase 17. (551 aa)
	KL	Klotho. (1032 aa)
	GNAI1	G protein subunit alpha i1. (323 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
	TRPV5	Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	SLC34A1	Solute carrier family 34 member 1. (641 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	FGFR1	Fibroblast growth factor receptor. (812 aa)
	RHOA	Uncharacterized protein. (206 aa)
	SLC34A2	Solute carrier family 34 member 2. (689 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
	SP1	Sp1 transcription factor. (786 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	BCL2	BCL2 apoptosis regulator. (193 aa)
	RXRG	Retinoid X receptor gamma. (473 aa)
	GNAS	GNAS complex locus. (1043 aa)
	PDE4C	Phosphodiesterase. (713 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	MMP25	ZnMc domain-containing protein. (194 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	CREB3	cAMP responsive element binding protein 3. (371 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (418 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
	MEF2A	Myocyte enhancer factor 2A. (505 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	GCM2	Glial cells missing transcription factor 2. (506 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	CASR	Calcium sensing receptor. (1078 aa)
	RUNX2	RUNX family transcription factor 2. (585 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (636 aa)
	PLD2	Phospholipase. (915 aa)
	VDR	Vitamin D receptor. (477 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	RXRB	Retinoid X receptor beta. (537 aa)
	MEF2D	Myocyte enhancer factor 2D. (520 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
	GNA11	G protein subunit alpha 11. (319 aa)
	SOST	Sclerostin. (213 aa)
	ARRB2	Arrestin beta 2. (447 aa)
	ATF4	Activating transcription factor 4. (340 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	AKAP13	A-kinase anchoring protein 13. (2813 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (968 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	GCM1	Glial cells missing transcription factor 1. (436 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
	MMP15	Matrix metallopeptidase 15. (669 aa)
	PDE4D	Phosphodiesterase. (706 aa)
	RXRA	Retinoid X receptor alpha. (472 aa)
	BGLAP	Osteocalcin; Binds strongly to apatite and calcium. (100 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	PDE4A	Phosphodiesterase. (793 aa)
	EGFR	Receptor protein-tyrosine kinase. (1201 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSPPAP00000033273	ENSPPAP00000023934	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.573
ADCY1	ADCY3	ENSPPAP00000033273	ENSPPAP00000030669	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY4	ENSPPAP00000033273	ENSPPAP00000031100	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.480
ADCY1	ADCY5	ENSPPAP00000033273	ENSPPAP00000025948	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY6	ENSPPAP00000033273	ENSPPAP00000015584	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.463
ADCY1	ADCY7	ENSPPAP00000033273	ENSPPAP00000007130	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.605
ADCY1	ADCY8	ENSPPAP00000033273	ENSPPAP00000028968	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.952
ADCY1	ADCY9	ENSPPAP00000033273	ENSPPAP00000003795	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.712
ADCY1	GNAI1	ENSPPAP00000033273	ENSPPAP00000014368	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.830
ADCY1	GNAI2	ENSPPAP00000033273	ENSPPAP00000017425	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.813
ADCY1	GNAI3	ENSPPAP00000033273	ENSPPAP00000030486	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.868
ADCY1	GNAS	ENSPPAP00000033273	ENSPPAP00000019582	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.980
ADCY1	GNAS-2	ENSPPAP00000033273	ENSPPAP00000020165	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.902
ADCY1	PDE4A	ENSPPAP00000033273	ENSPPAP00000042582	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.797
ADCY1	PDE4B	ENSPPAP00000033273	ENSPPAP00000020220	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.735
ADCY1	PDE4C	ENSPPAP00000033273	ENSPPAP00000019601	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.724
ADCY1	PDE4D	ENSPPAP00000033273	ENSPPAP00000038107	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.729
ADCY1	PLCB1	ENSPPAP00000033273	ENSPPAP00000005635	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.495
ADCY1	PRKACA	ENSPPAP00000033273	ENSPPAP00000003342	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.947
ADCY1	PRKACB	ENSPPAP00000033273	ENSPPAP00000017680	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.948