STRINGSTRING
COL1A1 COL1A1 COL4A6 COL4A6 MAPK8 MAPK8 PIK3R3 PIK3R3 TNF TNF THBD THBD NOX1 NOX1 PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 COL4A1 COL4A1 PLCD1 PLCD1 AGT AGT SMAD4 SMAD4 PIK3R2 PIK3R2 PIK3CA PIK3CA CYBB CYBB AGER AGER AKT2 AKT2 HRAS HRAS PIM1 PIM1 DIAPH1 DIAPH1 CDKN1B CDKN1B MAPK12 MAPK12 CASP3 CASP3 CXCL8 CXCL8 EGR1 EGR1 EDN1 EDN1 TGFBR1 TGFBR1 FOXO1 FOXO1 NFATC1 NFATC1 CDC42 CDC42 COL4A3 COL4A3 COL4A2 COL4A2 TGFB1 TGFB1 PRKCA PRKCA COL3A1 COL3A1 TGFB3 TGFB3 PIK3CB PIK3CB BCL2 BCL2 NFKB1 NFKB1 IL1A IL1A RELA RELA RAC1 RAC1 PRKCE PRKCE F3 F3 PLCE1 PLCE1 CCL2 CCL2 LOC100989777 LOC100989777 PRKCD PRKCD SMAD3 SMAD3 ICAM1 ICAM1 PRKCB PRKCB SMAD2 SMAD2 AKT3 AKT3 COL4A5 COL4A5 IL6 IL6 AGTR1 AGTR1 MAPK11 MAPK11 CDK4 CDK4 PLCD3 PLCD3 COL4A4 COL4A4 MAPK13 MAPK13 NRAS NRAS MAPK9 MAPK9 NOS3 NOS3 PLCG2 PLCG2 STAT1 STAT1 STAT5B STAT5B BAX BAX PLCB2 PLCB2 MMP2 MMP2 IL1B IL1B AKT1 AKT1 PLCB3 PLCB3 STAT3 STAT3 SELE SELE FN1 FN1 VEGFD VEGFD MAPK14 MAPK14 PIK3R1 PIK3R1 STAT5A STAT5A COL1A2 COL1A2 PRKCZ PRKCZ MAPK10 MAPK10 NOX4 NOX4 VEGFC VEGFC SERPINE1 SERPINE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL1A1Collagen type I alpha 1 chain. (1463 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
THBDThrombomodulin. (631 aa)
NOX1NADPH oxidase 1. (564 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PLCD1Phosphoinositide phospholipase C. (781 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIM1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (406 aa)
DIAPH1FH2 domain-containing protein. (507 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
EDN1Endothelin 1. (212 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
FOXO1Fork-head domain-containing protein. (527 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
CDC42Uncharacterized protein. (191 aa)
COL4A3Collagen type IV alpha 3 chain. (1641 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RAC1Uncharacterized protein. (224 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
PLCE1Phosphoinositide phospholipase C. (2276 aa)
CCL2C-C motif chemokine. (99 aa)
LOC100989777Uncharacterized protein. (191 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
COL4A5Collagen type IV alpha 5 chain. (1664 aa)
IL6Uncharacterized protein. (198 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PLCD3Phosphoinositide phospholipase C. (737 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOS3Nitric oxide synthase 3. (997 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
MMP2Matrix metallopeptidase 2. (664 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
SELESelectin E. (612 aa)
FN1Fibronectin 1. (2477 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NOX4Ferric oxidoreductase domain-containing protein. (285 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (324 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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