(23 nodes) Vitamin digestion and absorption network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOB	Apolipoprotein B. (4535 aa)
	PNLIP	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	PLB1	Phospholipase B1. (1459 aa)
	LOC100969990	Uncharacterized protein. (659 aa)
	SLC19A1	Solute carrier family 19 member 1. (591 aa)
	SLC46A1	Solute carrier family 46 member 1. (417 aa)
	RBP2	Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
	CUBN	Cubilin. (3623 aa)
	LMBRD1	LMBR1 domain containing 1. (540 aa)
	SLC52A3	Solute carrier family 52 member 3. (472 aa)
	BTD	Biotinidase. (545 aa)
	CBLIF	Cobalamin binding intrinsic factor. (417 aa)
	APOA4	Apolipoprotein A4. (396 aa)
	AWAT2	Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
	SLC5A6	Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (636 aa)
	LRAT	Lecithin retinol acyltransferase. (230 aa)
	TCN1	Transcobalamin 1. (433 aa)
	SLC19A3	Solute carrier family 19 member 3. (496 aa)
	MMACHC	Metabolism of cobalamin associated C. (282 aa)
	TCN2	Transcobalamin 2. (427 aa)
	SLC23A1	Solute carrier family 23 member 1. (598 aa)
	SLC19A2	Solute carrier family 19 member 2. (497 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APOA4	ENSPPAP00000007656	ENSPPAP00000028262	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A4.	0.802
APOA1	APOB	ENSPPAP00000007656	ENSPPAP00000002804	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein B.	0.820
APOA4	APOA1	ENSPPAP00000028262	ENSPPAP00000007656	Apolipoprotein A4.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.802
APOA4	APOB	ENSPPAP00000028262	ENSPPAP00000002804	Apolipoprotein A4.	Apolipoprotein B.	0.906
APOB	APOA1	ENSPPAP00000002804	ENSPPAP00000007656	Apolipoprotein B.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.820
APOB	APOA4	ENSPPAP00000002804	ENSPPAP00000028262	Apolipoprotein B.	Apolipoprotein A4.	0.906
APOB	RBP2	ENSPPAP00000002804	ENSPPAP00000016859	Apolipoprotein B.	Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.575
BTD	SLC19A2	ENSPPAP00000025398	ENSPPAP00000042705	Biotinidase.	Solute carrier family 19 member 2.	0.477
BTD	SLC19A3	ENSPPAP00000025398	ENSPPAP00000039310	Biotinidase.	Solute carrier family 19 member 3.	0.560
CBLIF	CUBN	ENSPPAP00000028197	ENSPPAP00000018422	Cobalamin binding intrinsic factor.	Cubilin.	0.997
CBLIF	TCN1	ENSPPAP00000028197	ENSPPAP00000039080	Cobalamin binding intrinsic factor.	Transcobalamin 1.	0.954
CUBN	CBLIF	ENSPPAP00000018422	ENSPPAP00000028197	Cubilin.	Cobalamin binding intrinsic factor.	0.997
CUBN	PLB1	ENSPPAP00000018422	ENSPPAP00000008579	Cubilin.	Phospholipase B1.	0.518
CUBN	TCN1	ENSPPAP00000018422	ENSPPAP00000039080	Cubilin.	Transcobalamin 1.	0.946
CUBN	TCN2	ENSPPAP00000018422	ENSPPAP00000040861	Cubilin.	Transcobalamin 2.	0.550
LMBRD1	MMACHC	ENSPPAP00000018503	ENSPPAP00000040055	LMBR1 domain containing 1.	Metabolism of cobalamin associated C.	0.791
LMBRD1	TCN1	ENSPPAP00000018503	ENSPPAP00000039080	LMBR1 domain containing 1.	Transcobalamin 1.	0.459
LMBRD1	TCN2	ENSPPAP00000018503	ENSPPAP00000040861	LMBR1 domain containing 1.	Transcobalamin 2.	0.618
LRAT	RBP2	ENSPPAP00000037702	ENSPPAP00000016859	Lecithin retinol acyltransferase.	Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.787
MMACHC	LMBRD1	ENSPPAP00000040055	ENSPPAP00000018503	Metabolism of cobalamin associated C.	LMBR1 domain containing 1.	0.791