STRINGSTRING
LIPC LIPC CD36 CD36 ABCG8 ABCG8 STAR STAR MYLIP MYLIP APOB APOB TSPO TSPO NCEH1 NCEH1 APOC3 APOC3 NPC1 NPC1 VAPA VAPA LDLRAP1 LDLRAP1 LPL LPL ABCG5 ABCG5 APOA1 APOA1 LDLR LDLR ANGPTL8 ANGPTL8 LRP1 LRP1 ANGPTL3 ANGPTL3 PCSK9 PCSK9 ABCB11 ABCB11 VAPB VAPB VDAC3 VDAC3 APOE APOE LIPG LIPG ANGPTL4 ANGPTL4 SORT1 SORT1 LCAT LCAT APOC1A APOC1A APOA2 APOA2 APOA4 APOA4 VDAC1 VDAC1 LIPA LIPA SOAT1 SOAT1 NPC2 NPC2 PLTP PLTP OSBPL5 OSBPL5 SOAT2 SOAT2 ABCA1 ABCA1 APOH APOH TSPO2 TSPO2 LRP2 LRP2 CYP27A1 CYP27A1 APOC2 APOC2 CYP7A1 CYP7A1 LRPAP1 LRPAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIPCLipase C, hepatic type. (490 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ABCG8ATP binding cassette subfamily G member 8. (673 aa)
STARSteroidogenic acute regulatory protein. (230 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
APOBApolipoprotein B. (4535 aa)
TSPOTranslocator protein. (169 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (440 aa)
APOC3Apolipoprotein C3. (99 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
VAPAVAMP associated protein A. (267 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (295 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
LDLRLow density lipoprotein receptor. (849 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
LRP1LDL receptor related protein 1. (4544 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (692 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
VAPBVAMP associated protein B and C. (243 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
APOEApolipoprotein E. (317 aa)
LIPGLipase G, endothelial type. (500 aa)
ANGPTL4Angiopoietin like 4. (406 aa)
SORT1Sortilin. (569 aa)
LCATLecithin-cholesterol acyltransferase. (440 aa)
APOC1ATruncated apolipoprotein C-I, acidic form. (95 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (133 aa)
APOA4Apolipoprotein A4. (396 aa)
VDAC1Voltage dependent anion channel 1. (289 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
SOAT1O-acyltransferase. (550 aa)
NPC2ML domain-containing protein. (221 aa)
PLTPPhospholipid transfer protein. (493 aa)
OSBPL5Oxysterol-binding protein; Belongs to the OSBP family. (879 aa)
SOAT2O-acyltransferase. (526 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
APOHApolipoprotein H. (345 aa)
TSPO2Translocator protein 2. (170 aa)
LRP2LDL receptor related protein 2. (4641 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (531 aa)
APOC2Uncharacterized protein. (178 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
LRPAP1LDL receptor related protein associated protein 1. (357 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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