STRINGSTRING
LOC106634335 LOC106634335 TRAF2 TRAF2 MAPK8 MAPK8 AFG3L2 AFG3L2 ATXN3 ATXN3 PSMD6 PSMD6 PIK3R3 PIK3R3 PSMA1 PSMA1 OMA1 OMA1 BECN2 BECN2 CYCS CYCS TBPL1 TBPL1 PLCB1 PLCB1 BEAN1 BEAN1 PLCB4 PLCB4 PSMA6 PSMA6 GRIA3 GRIA3 ADRM1 ADRM1 GRIN3A GRIN3A PSMA4 PSMA4 LOC103785895 LOC103785895 PSMA7 PSMA7 ATG2A ATG2A GRIN2B GRIN2B PSMD12 PSMD12 NOP56 NOP56 ATG101 ATG101 GRIN3B GRIN3B PSMD9 PSMD9 PSMC2 PSMC2 PSMA8 PSMA8 ITPR2 ITPR2 SPTBN2 SPTBN2 ATXN2 ATXN2 XBP1 XBP1 PIK3R2 PIK3R2 ATXN10 ATXN10 PIK3CA PIK3CA NRBF2 NRBF2 GNAQ GNAQ GRIA1 GRIA1 AKT2 AKT2 PSMD3 PSMD3 ATXN1 ATXN1 VLDLR VLDLR PSMB4 PSMB4 PSMC1 PSMC1 SLC25A31 SLC25A31 PIK3C3 PIK3C3 PIK3R4 PIK3R4 GRIN1 GRIN1 ERN1 ERN1 PDYN PDYN TBP TBP PSMD14 PSMD14 PSMD4 PSMD4 ATG14 ATG14 PRKCA PRKCA SP1 SP1 PSMC4 PSMC4 PIK3CB PIK3CB DAB1 DAB1 PPIF PPIF PSMD8 PSMD8 TBPL2 TBPL2 RYR1 RYR1 TRPC3 TRPC3 PSMC6 PSMC6 CIC CIC GRIN2A GRIN2A PRKCB PRKCB VDAC3 VDAC3 GRIN2D GRIN2D RELN RELN PSMD1 PSMD1 WIPI2 WIPI2 TWNK TWNK LOC100989438 LOC100989438 PSMA3 PSMA3 AKT3 AKT3 PSMD2 PSMD2 PSMA2 PSMA2 MCU MCU MTOR MTOR MYOD1 MYOD1 ATP2A1 ATP2A1 ULK2 ULK2 SLC25A5 SLC25A5 RBPJL RBPJL ATG2B ATG2B VDAC1 VDAC1 SLC25A4 SLC25A4 BECN1 BECN1 MAPK9 MAPK9 RORA RORA GRIA2 GRIA2 FGF14 FGF14 ATP2A3 ATP2A3 PSMD7 PSMD7 ATXN2L ATXN2L PSMA5 PSMA5 KCND3 KCND3 PSMB1 PSMB1 PLCB2 PLCB2 RB1CC1 RB1CC1 AKT1 AKT1 PLCB3 PLCB3 ITPR3 ITPR3 MAP3K5 MAP3K5 ITPR1 ITPR1 PSMB3 PSMB3 RBPJ RBPJ PIK3R1 PIK3R1 WIPI1 WIPI1 PSMC3 PSMC3 ATP2A2 ATP2A2 SLC1A6 SLC1A6 MAPK10 MAPK10 GRM1 GRM1 PSMB5 PSMB5 PSMB6 PSMB6 PSMB7 PSMB7 SEM1 SEM1 PSMB2 PSMB2 PSMC5 PSMC5 PSMD13 PSMD13 KCNC3 KCNC3 PSMD11 PSMD11
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC106634335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (797 aa)
ATXN3Josephin domain-containing protein. (312 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PSMA1Proteasome endopeptidase complex. (238 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
BECN2Beclin 2. (431 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
BEAN1Brain expressed associated with NEDD4 1. (256 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
ADRM1Adhesion regulating molecule 1. (407 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1068 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
LOC103785895Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
ATG2AAutophagy related 2A. (1938 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (480 aa)
NOP56NOP56 ribonucleoprotein. (594 aa)
ATG101Autophagy related 101. (218 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (880 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (432 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
ATXN2Ataxin 2. (1248 aa)
XBP1BZIP domain-containing protein. (380 aa)
PIK3R2Uncharacterized protein. (663 aa)
ATXN10Ataxin 10. (475 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
NRBF2Uncharacterized protein. (288 aa)
GNAQG protein subunit alpha q. (313 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
ATXN1Ataxin 1. (812 aa)
VLDLRVery low density lipoprotein receptor. (1038 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
PDYNProdynorphin. (254 aa)
TBPTATA-box binding protein. (357 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (384 aa)
ATG14Autophagy related 14. (492 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
SP1Sp1 transcription factor. (786 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
DAB1DAB adaptor protein 1. (588 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
TBPL2TATA-box binding protein like 2. (375 aa)
RYR1Ryanodine receptor 1. (4924 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (899 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
CICHMG box domain-containing protein. (2496 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
GRIN2DUncharacterized protein. (806 aa)
RELNReelin. (3460 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (952 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (454 aa)
TWNKTwinkle mtDNA helicase. (582 aa)
LOC100989438Uncharacterized protein. (873 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
MCUMitochondrial calcium uniporter. (301 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (873 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1007 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
ATG2BAutophagy related 2B. (2073 aa)
VDAC1Voltage dependent anion channel 1. (289 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (261 aa)
BECN1Beclin 1. (450 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RORARAR related orphan receptor A. (559 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (296 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1017 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
ATXN2LAtaxin 2 like. (1050 aa)
PSMA5Proteasome subunit alpha type. (242 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
PSMB1Proteasome subunit beta. (241 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
PSMB3Proteasome subunit beta. (202 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (455 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1034 aa)
SLC1A6Amino acid transporter. (564 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
GRM1Glutamate metabotropic receptor 1. (1194 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMB6Proteasome subunit beta. (244 aa)
PSMB7Proteasome subunit beta. (277 aa)
SEM1Uncharacterized protein. (89 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (399 aa)
KCNC3Uncharacterized protein. (44 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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