57 items (Pan paniscus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	SLC18A2	Solute carrier family 18 member A2. (514 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (395 aa)
	CALML5	Calmodulin like 5. (146 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1068 aa)
	SIRT1	Sirtuin 1. (693 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (880 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (179 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
	DDC	Dopa decarboxylase. (489 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
	PDYN	Prodynorphin. (254 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	GNAS	GNAS complex locus. (1043 aa)
	MAOA	Amine oxidase. (527 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	CALML4	Calmodulin like 4. (196 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	MAOB	Amine oxidase. (520 aa)
	CREB3	cAMP responsive element binding protein 3. (371 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (418 aa)
	GRIN2D	Uncharacterized protein. (806 aa)
	LOC100989438	Uncharacterized protein. (873 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (149 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	SLC18A1	Solute carrier family 18 member A1. (508 aa)
	ATF4	Activating transcription factor 4. (340 aa)
	CALML6	Calmodulin like 6. (181 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CACNA1C	ENSPPAP00000025948	ENSPPAP00000016346	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.568
ADCY5	CALM3	ENSPPAP00000025948	ENSPPAP00000029183	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.762
ADCY5	CALML3	ENSPPAP00000025948	ENSPPAP00000006554	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.779
ADCY5	CALML4	ENSPPAP00000025948	ENSPPAP00000020274	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.773
ADCY5	CALML5	ENSPPAP00000025948	ENSPPAP00000005888	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.779
ADCY5	CALML6	ENSPPAP00000025948	ENSPPAP00000034585	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.773
ADCY5	CAMK2A	ENSPPAP00000025948	ENSPPAP00000039041	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.910
ADCY5	CAMK4	ENSPPAP00000025948	ENSPPAP00000036943	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily.	0.901
ADCY5	GNAS	ENSPPAP00000025948	ENSPPAP00000019582	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.980
ADCY5	GNAS-2	ENSPPAP00000025948	ENSPPAP00000020165	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.902
ADCY5	PRKACA	ENSPPAP00000025948	ENSPPAP00000003342	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.930
ADCY5	PRKACB	ENSPPAP00000025948	ENSPPAP00000017680	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.921
ADCY5	PRKACG	ENSPPAP00000025948	ENSPPAP00000002963	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.921
ADCY5	PRKCA	ENSPPAP00000025948	ENSPPAP00000017194	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.949
ADCY5	PRKCB	ENSPPAP00000025948	ENSPPAP00000022486	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.913
ARC	CAMK2A	ENSPPAP00000000134	ENSPPAP00000039041	Activity regulated cytoskeleton associated protein.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.554
ARC	FOS	ENSPPAP00000000134	ENSPPAP00000005084	Activity regulated cytoskeleton associated protein.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.646
ARC	FOSB	ENSPPAP00000000134	ENSPPAP00000025743	Activity regulated cytoskeleton associated protein.	FosB proto-oncogene, AP-1 transcription factor subunit.	0.471
ARC	GRIA1	ENSPPAP00000000134	ENSPPAP00000010714	Activity regulated cytoskeleton associated protein.	Glutamate ionotropic receptor AMPA type subunit 1.	0.637
ARC	GRIN2B	ENSPPAP00000000134	ENSPPAP00000007453	Activity regulated cytoskeleton associated protein.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.622