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LOC100985978 LOC100985978 H2AC6 H2AC6 H2AC1 H2AC1 LOC100975795 LOC100975795 LOC103783476 LOC103783476 H3-3A H3-3A LOC100982497 LOC100982497 PKIA PKIA H2BC5 H2BC5 PRKACG PRKACG H2AC14 H2AC14 H2AW H2AW PRKACA PRKACA H2BC10 H2BC10 DRD1 DRD1 ENSPPAP00000003652 ENSPPAP00000003652 ARAF ARAF NPY NPY H2AC16 H2AC16 H2BC1 H2BC1 SLC18A2 SLC18A2 H2AC21 H2AC21 H3-4 H3-4 H2BC18 H2BC18 CRH CRH LOC100980195 LOC100980195 CREB3L4 CREB3L4 LOC100987642 LOC100987642 LOC100992822 LOC100992822 H2AC20 H2AC20 HDAC8 HDAC8 H2BC9 H2BC9 H2BC11 H2BC11 CALML5 CALML5 LOC100981154 LOC100981154 GNG2 GNG2 H2AJ H2AJ H2BC13 H2BC13 MAPK1 MAPK1 LOC100985433 LOC100985433 H2AC7 H2AC7 CALML3 CALML3 H2BC14 H2BC14 H2BC3 H2BC3 GRIN3A GRIN3A H2BU1 H2BU1 GRIN2B GRIN2B SOS1 SOS1 SLC6A3 SLC6A3 GRIN3B GRIN3B GNGT1 GNGT1 ATF2 ATF2 MACROH2A2 MACROH2A2 GNGT2 GNGT2 GRB2 GRB2 SHC3 SHC3 PPP1R1B PPP1R1B ADORA2B ADORA2B MAP2K1 MAP2K1 HRAS HRAS PPP1CB PPP1CB BDNF BDNF MACROH2A1 MACROH2A1 DDC DDC CREB3L1 CREB3L1 GNB2 GNB2 DRD2 DRD2 PPP1CC PPP1CC GNAI1 GNAI1 SHC1 SHC1 CREB5 CREB5 GRIN1 GRIN1 LOC100969533 LOC100969533 PDYN PDYN H2AZ1 H2AZ1 GNAI2 GNAI2 PRKACB PRKACB HDAC5 HDAC5 GNG3 GNG3 ADORA2A ADORA2A SLC29A2 SLC29A2 HDAC1 HDAC1 GNAS GNAS MAOA MAOA HDAC2 HDAC2 GNAS-2 GNAS-2 SLC29A3 SLC29A3 CALML4 CALML4 ATF6B ATF6B HDAC6 HDAC6 LOC100985638 LOC100985638 GNG8 GNG8 GNG4 GNG4 MAOB MAOB SLC29A1 SLC29A1 CREB3 CREB3 GRIN2A GRIN2A CREB3L3 CREB3L3 GRIN2D GRIN2D RAF1 RAF1 LOC100989438 LOC100989438 HDAC4 HDAC4 FOSB FOSB BRAF BRAF CAMKK2 CAMKK2 ADCY5 ADCY5 CAMKK1 CAMKK1 GNG7 GNG7 H2AZ2 H2AZ2 HDAC3 HDAC3 CALM3 CALM3 HDAC11 HDAC11 NTRK2 NTRK2 NRAS NRAS GNB1 GNB1 GNAI3 GNAI3 SLC18A1 SLC18A1 ATF4 ATF4 GNB5 GNB5 CALML6 CALML6 SOS2 SOS2 GNG11 GNG11 CAMK4 CAMK4 HDAC10 HDAC10 GNAO1 GNAO1 SHC4 SHC4 HDAC7 HDAC7 LOC100988917 LOC100988917 CREB3L2 CREB3L2 GNB3 GNB3 HDAC9 HDAC9 SHC2 SHC2 HAT1 HAT1 GNB4 GNB4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100985978Histone H3; Belongs to the histone H3 family. (136 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC100975795Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
LOC103783476Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
LOC100982497Histone H2A; Belongs to the histone H2A family. (128 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ENSPPAP00000003652Histone H2A; Belongs to the histone H2A family. (129 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
NPYNeuropeptide Y. (97 aa)
H2AC16Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
H3-4Histone cluster 3 H3. (136 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
CRHCorticotropin releasing hormone. (196 aa)
LOC100980195Histone H2A; Belongs to the histone H2A family. (130 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
LOC100987642Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100992822Histone H2A; Belongs to the histone H2A family. (115 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (396 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
CALML5Calmodulin like 5. (146 aa)
LOC100981154Histone H2B; Belongs to the histone H2B family. (126 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
LOC100985433Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1068 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (880 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SHC3SHC adaptor protein 3. (501 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (179 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (357 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
DDCDopa decarboxylase. (489 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GNB2G protein subunit beta 2. (340 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
GNAI1G protein subunit alpha i1. (323 aa)
SHC1SHC adaptor protein 1. (584 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
LOC100969533Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
PDYNProdynorphin. (254 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
SLC29A2Solute carrier family 29 member 2. (456 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
GNASGNAS complex locus. (1043 aa)
MAOAAmine oxidase. (527 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
GNAS-2Uncharacterized protein. (245 aa)
SLC29A3Solute carrier family 29 member 3. (475 aa)
CALML4Calmodulin like 4. (196 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
HDAC6Histone deacetylase 6. (1215 aa)
LOC100985638Histone H2B; Belongs to the histone H2B family. (167 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAOBAmine oxidase. (520 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (498 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
GRIN2DUncharacterized protein. (806 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
LOC100989438Uncharacterized protein. (873 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
HDAC11Histone deacetylase 11. (320 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNB1G protein subunit beta 1. (340 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SLC18A1Solute carrier family 18 member A1. (508 aa)
ATF4Activating transcription factor 4. (340 aa)
GNB5G protein subunit beta 5. (395 aa)
CALML6Calmodulin like 6. (181 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
HDAC10Histone deacetylase 10. (669 aa)
GNAO1G protein subunit alpha o1. (354 aa)
SHC4SHC adaptor protein 4. (630 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1011 aa)
LOC100988917Histone domain-containing protein; Belongs to the histone H2B family. (153 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GNB3G protein subunit beta 3. (340 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1058 aa)
SHC2Uncharacterized protein. (539 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
GNB4G protein subunit beta 4. (340 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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