STRINGSTRING
LOC100968163 LOC100968163 TICAM2 TICAM2 TIRAP TIRAP MAPK8 MAPK8 CFL2 CFL2 IL10 IL10 TNF TNF FOS FOS CALML5 CALML5 MAPK1 MAPK1 CALML3 CALML3 IRAK4 IRAK4 C1QC C1QC LY96 LY96 NOD1 NOD1 MAPK12 MAPK12 CASP3 CASP3 CXCL8 CXCL8 CASP1 CASP1 GNAI1 GNAI1 TLR4 TLR4 RHOA RHOA GNAI2 GNAI2 NFKB1 NFKB1 IL1A IL1A RELA RELA C5 C5 NOS2 NOS2 LOC100988452 LOC100988452 CALML4 CALML4 C4BPB C4BPB CXCL5 CXCL5 C1R C1R IRF8 IRF8 IL6 IL6 IRF3 IRF3 CARD17 CARD17 C3 C3 MAPK11 MAPK11 IRF1 IRF1 CASP7 CASP7 IL12B IL12B CXCL6 CXCL6 ITGAM ITGAM MYD88 MYD88 CALM3 CALM3 MAPK13 MAPK13 MAPK9 MAPK9 GNAI3 GNAI3 IL12A IL12A ITGB1 ITGB1 C1QB C1QB CCDC125 CCDC125 SERPING1 SERPING1 C4BPA C4BPA CALML6 CALML6 IRAK1 IRAK1 IL1B IL1B ITGA5 ITGA5 CD14 CD14 CFL1 CFL1 MAPK14 MAPK14 C1S C1S MAPK10 MAPK10 TRAF6 TRAF6 IL23A IL23A PYCARD PYCARD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100968163Uncharacterized protein. (579 aa)
TICAM2TIR domain-containing adaptor molecule 2. (235 aa)
TIRAPTIR domain-containing protein. (226 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
IL10Interleukin 10. (178 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CALML5Calmodulin like 5. (146 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
C1QCComplement C1q C chain. (245 aa)
LY96MD2 protein. (160 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (403 aa)
GNAI1G protein subunit alpha i1. (323 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
RHOAUncharacterized protein. (206 aa)
GNAI2G protein subunit alpha i2. (355 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
C5Complement C5. (1676 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
LOC100988452Uncharacterized protein. (1725 aa)
CALML4Calmodulin like 4. (196 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
CXCL5C-X-C motif chemokine. (114 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (704 aa)
IRF8Interferon regulatory factor 8. (426 aa)
IL6Uncharacterized protein. (198 aa)
IRF3Interferon regulatory factor 3. (452 aa)
CARD17Caspase recruitment domain family member 17. (110 aa)
C3Complement C3. (1614 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
IRF1Interferon regulatory factor. (325 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CXCL6C-X-C motif chemokine. (114 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAI3G protein subunit alpha i3. (354 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
C1QBComplement C1q B chain. (253 aa)
CCDC125Coiled-coil domain containing 125. (486 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (496 aa)
C4BPAComplement component 4 binding protein alpha. (597 aa)
CALML6Calmodulin like 6. (181 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1046 aa)
CD14CD14 molecule. (384 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (204 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (780 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PYCARDPYD and CARD domain containing. (195 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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