STRINGSTRING
CR1L CR1L IL10 IL10 NFKBIB NFKBIB JAK1 JAK1 LOC100986914 LOC100986914 TNF TNF LOC100979649 LOC100979649 FOS FOS MAPK1 MAPK1 NCF4 NCF4 IFNGR2 IFNGR2 TLR2 TLR2 HLA-DOB HLA-DOB EEF1A2 EEF1A2 IL4 IL4 ENSPPAP00000008696 ENSPPAP00000008696 PTPN6 PTPN6 TAB1 TAB1 MAP3K7 MAP3K7 IRAK4 IRAK4 LOC100993508 LOC100993508 ENSPPAP00000009755 ENSPPAP00000009755 CYBB CYBB MAPK12 MAPK12 LOC100986750 LOC100986750 TAB2 TAB2 FCGR2A FCGR2A TLR4 TLR4 TGFB1 TGFB1 TGFB3 TGFB3 NCF1 NCF1 HLA-DPA1 HLA-DPA1 NFKB1 NFKB1 IL1A IL1A IFNGR1 IFNGR1 RELA RELA NOS2 NOS2 PRKCB PRKCB C3 C3 MAPK11 MAPK11 HLA-DOA HLA-DOA ITGA4 ITGA4 IL12B IL12B ITGAM ITGAM MYD88 MYD88 MHC-DMB MHC-DMB MAPK13 MAPK13 HLA-DQA2 HLA-DQA2 IL12A IL12A NCF2 NCF2 LOC100993847 LOC100993847 EEF1A1 EEF1A1 ITGB1 ITGB1 STAT1 STAT1 FCGR1A FCGR1A IRAK1 IRAK1 IL1B IL1B LOC103785316 LOC103785316 CR1 CR1 HLA-DQB1 HLA-DQB1 HLA-DQB2 HLA-DQB2 HLA-DPB1 HLA-DPB1 NFKBIA NFKBIA HLA-DRA HLA-DRA MAPK14 MAPK14 IFNG IFNG TRAF6 TRAF6 ELK1 ELK1 PTGS2 PTGS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CR1LComplement C3b/C4b receptor 1 like. (569 aa)
IL10Interleukin 10. (178 aa)
NFKBIBANK_REP_REGION domain-containing protein. (270 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
LOC100986914Uncharacterized protein. (210 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC100979649Ig-like domain-containing protein. (170 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
NCF4Uncharacterized protein. (368 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (266 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (420 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ENSPPAP00000008696Ig-like domain-containing protein. (147 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LOC100993508Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ENSPPAP00000009755Ig-like domain-containing protein. (116 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
LOC100986750Ig-like domain-containing protein. (287 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
FCGR2AFc fragment of IgG receptor IIa. (316 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
C3Complement C3. (1614 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MHC-DMBIg-like domain-containing protein. (276 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
LOC100993847Ig-like domain-containing protein. (270 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
FCGR1AUncharacterized protein. (368 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
CR1Uncharacterized protein. (582 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ELK1ETS transcription factor ELK1. (428 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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