STRINGSTRING
LOC100992309 LOC100992309 MAPK8 MAPK8 CALR CALR IL10 IL10 PIK3R3 PIK3R3 CD3D CD3D PPP2R1A PPP2R1A TNF TNF TNFRSF1A TNFRSF1A LOC100986336 LOC100986336 IKBKG IKBKG FOS FOS PPP2R2D PPP2R2D PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 IFNGR2 IFNGR2 CD3G CD3G LOC100967628 LOC100967628 TLR2 TLR2 CFLAR CFLAR GNAL GNAL IRAK4 IRAK4 C1QC C1QC MAP2K4 MAP2K4 PIK3R2 PIK3R2 ACE ACE PIK3CA PIK3CA GNAQ GNAQ FASLG FASLG AKT2 AKT2 MAPK12 MAPK12 CXCL8 CXCL8 PPP2CA PPP2CA GNAI1 GNAI1 IL2 IL2 TGFBR1 TGFBR1 TLR4 TLR4 TGFB1 TGFB1 TGFB3 TGFB3 PIK3CB PIK3CB GNAI2 GNAI2 CD3E CD3E NFKB1 NFKB1 IFNGR1 IFNGR1 RELA RELA GNAS GNAS NOS2 NOS2 CCL2 CCL2 GNAS-2 GNAS-2 BDKRB2 BDKRB2 IKBKB IKBKB FADD FADD PPP2R2A PPP2R2A SMAD2 SMAD2 AKT3 AKT3 PPP2CB PPP2CB IL6 IL6 FAS FAS C3 C3 MAPK11 MAPK11 IL12B IL12B MYD88 MYD88 MAPK13 MAPK13 CHUK CHUK MAPK9 MAPK9 GNAI3 GNAI3 IL12A IL12A GNA11 GNA11 C1QB C1QB PPP2R2C PPP2R2C ADCY1 ADCY1 GNA14 GNA14 PLCB2 PLCB2 IRAK1 IRAK1 IL1B IL1B AKT1 AKT1 PLCB3 PLCB3 GNA15 GNA15 GNAO1 GNAO1 NFKBIA NFKBIA MAPK14 MAPK14 IFNG IFNG PIK3R1 PIK3R1 MAPK10 MAPK10 TRAF6 TRAF6 PPP2R2B PPP2R2B CD247 CD247 CCL5 CCL5 SERPINE1 SERPINE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100992309C-C motif chemokine. (92 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CALRCalreticulin. (417 aa)
IL10Interleukin 10. (178 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
CD3DCD3d molecule. (171 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
CD3GCD3g molecule. (182 aa)
LOC100967628C-C motif chemokine. (93 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
GNALUncharacterized protein. (381 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
C1QCComplement C1q C chain. (245 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
PIK3R2Uncharacterized protein. (663 aa)
ACEAngiotensin-converting enzyme. (1223 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
GNAQG protein subunit alpha q. (313 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
PPP2CASerine/threonine-protein phosphatase. (294 aa)
GNAI1G protein subunit alpha i1. (323 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CD3ECD3e molecule. (207 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
GNASGNAS complex locus. (1043 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
CCL2C-C motif chemokine. (99 aa)
GNAS-2Uncharacterized protein. (245 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
FADDDeath domain-containing protein. (144 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
IL6Uncharacterized protein. (198 aa)
FASFas cell surface death receptor. (335 aa)
C3Complement C3. (1614 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAI3G protein subunit alpha i3. (354 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GNA11G protein subunit alpha 11. (319 aa)
C1QBComplement C1q B chain. (253 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (535 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
GNA14Uncharacterized protein. (157 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
GNA15G protein subunit alpha 15. (374 aa)
GNAO1G protein subunit alpha o1. (354 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CD247CD247 molecule. (163 aa)
CCL5C-C motif chemokine. (91 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (324 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.