95 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	PRDX1	Peroxiredoxin 1. (199 aa)
	COL4A6	Collagen type IV alpha 6 chain. (1705 aa)
	C8G	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
	IL10	Interleukin 10. (178 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
	MUC2	Uncharacterized protein. (1591 aa)
	CTSG	Cathepsin G; Belongs to the peptidase S1 family. (255 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	LAMA3	Laminin subunit alpha 3. (3333 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1669 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	ENSPPAP00000008696	Ig-like domain-containing protein. (147 aa)
	GNAL	Uncharacterized protein. (381 aa)
	ENSPPAP00000009755	Ig-like domain-containing protein. (116 aa)
	PIK3R2	Uncharacterized protein. (663 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
	LAMB3	Laminin subunit beta 3. (1171 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	LAMB1	Laminin subunit beta 1. (1786 aa)
	IL1R2	Interleukin 1 receptor type 2. (398 aa)
	CD1E	CD1e molecule. (388 aa)
	LAMA2	Laminin subunit alpha 2. (3122 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	CXCL1	C-X-C motif chemokine. (107 aa)
	LAMA5	Laminin subunit alpha 5. (3648 aa)
	C8A	Complement C8 alpha chain. (584 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1641 aa)
	LAMA1	Laminin subunit alpha 1. (3104 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1711 aa)
	ARG1	Arginase. (322 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
	COL3A1	Collagen type III alpha 1 chain. (1465 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	CD1D	CD1d molecule. (335 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	GNAS	GNAS complex locus. (1043 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	LAMC1	Laminin subunit gamma 1. (1609 aa)
	LAMC3	Laminin subunit gamma 3. (1559 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	LAMB2	Laminin subunit beta 2. (1780 aa)
	SERPINB9	Serpin family B member 9; Belongs to the serpin family. (376 aa)
	RAB5B	RAB5B, member RAS oncogene family. (223 aa)
	LAMC2	Laminin subunit gamma 2. (1193 aa)
	COL4A5	Collagen type IV alpha 5 chain. (1664 aa)
	IL6	Uncharacterized protein. (198 aa)
	CD1A	CD1a molecule. (307 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	C9	Complement C9. (559 aa)
	RAB5C	RAB5C, member RAS oncogene family. (249 aa)
	ACTN1	Actinin alpha 1. (914 aa)
	ITGAM	Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
	RAB7B	RAB7B, member RAS oncogene family. (199 aa)
	COL4A4	Collagen type IV alpha 4 chain. (1690 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	LAMB4	Laminin subunit beta 4. (1746 aa)
	CXCL2	C-X-C motif chemokine. (107 aa)
	GNA11	G protein subunit alpha 11. (319 aa)
	IL1R1	Interleukin 1 receptor type 1. (569 aa)
	C8B	Complement C8 beta chain. (591 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
	LAMA4	Laminin subunit alpha 4. (1823 aa)
	GNA14	Uncharacterized protein. (157 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	CD1C	CD1c molecule. (333 aa)
	ACTN4	Actinin alpha 4. (931 aa)
	LOC103785316	Ig-like domain-containing protein. (221 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	GNA15	G protein subunit alpha 15. (374 aa)
	FN1	Fibronectin 1. (2477 aa)
	CD14	CD14 molecule. (384 aa)
	RAB5A	RAB5A, member RAS oncogene family. (216 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	COL1A2	Collagen type I alpha 2 chain. (1274 aa)
	ARG2	Arginase. (354 aa)
	SERPINB13	Serpin family B member 13; Belongs to the serpin family. (400 aa)
	SERPINB10	Serpin family B member 10; Belongs to the serpin family. (397 aa)
	CD1B	CD1b molecule. (333 aa)
	SERPINB6	Serpin family B member 6; Belongs to the serpin family. (412 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	ACTN4	ENSPPAP00000028365	ENSPPAP00000035684	Actinin alpha 1.	Actinin alpha 4.	0.993
ACTN4	ACTN1	ENSPPAP00000035684	ENSPPAP00000028365	Actinin alpha 4.	Actinin alpha 1.	0.993
ACTN4	PRKCA	ENSPPAP00000035684	ENSPPAP00000017194	Actinin alpha 4.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.477
ADCY1	GNAL	ENSPPAP00000033273	ENSPPAP00000009048	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.879
ADCY1	GNAS	ENSPPAP00000033273	ENSPPAP00000019582	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.980
ADCY1	GNAS-2	ENSPPAP00000033273	ENSPPAP00000020165	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.902
ADCY1	PLCB1	ENSPPAP00000033273	ENSPPAP00000005635	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.495
ADCY1	PRKACA	ENSPPAP00000033273	ENSPPAP00000003342	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.947
ADCY1	PRKACB	ENSPPAP00000033273	ENSPPAP00000017680	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.948
ADCY1	PRKACG	ENSPPAP00000033273	ENSPPAP00000002963	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.959
ADCY1	PRKCA	ENSPPAP00000033273	ENSPPAP00000017194	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.928
ADCY1	PRKCB	ENSPPAP00000033273	ENSPPAP00000022486	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.908
ARG1	ARG2	ENSPPAP00000016880	ENSPPAP00000039767	Arginase.	Arginase.	0.910
ARG1	CSF2	ENSPPAP00000016880	ENSPPAP00000036895	Arginase.	Colony stimulating factor 2.	0.521
ARG1	CXCL1	ENSPPAP00000016880	ENSPPAP00000014887	Arginase.	C-X-C motif chemokine.	0.432
ARG1	IFNG	ENSPPAP00000016880	ENSPPAP00000038608	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.687
ARG1	IL10	ENSPPAP00000016880	ENSPPAP00000001878	Arginase.	Interleukin 10.	0.748
ARG1	IL1B	ENSPPAP00000016880	ENSPPAP00000034853	Arginase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.592
ARG1	IL6	ENSPPAP00000016880	ENSPPAP00000025189	Arginase.	Uncharacterized protein.	0.665
ARG1	ITGAM	ENSPPAP00000016880	ENSPPAP00000028433	Arginase.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.584