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| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | LOC106634335 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TIRAP | TIR domain-containing protein. (226 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IFNA17 | Interferon alpha 17. (189 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | IFNA6 | Interferon alpha 6. (189 aa) |
| | CR1L | Complement C3b/C4b receptor 1 like. (569 aa) |
| | IL10 | Interleukin 10. (178 aa) |
| | LOC100972005 | Uncharacterized protein. (198 aa) |
| | IFNA5 | Interferon alpha 5. (189 aa) |
| | IFNA10 | Interferon alpha 10. (189 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (325 aa) |
| | IFNA8 | Interferon alpha 8. (189 aa) |
| | JAK1 | Tyrosine-protein kinase. (1153 aa) |
| | CYCS | Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | LOC100986336 | TIR domain-containing protein. (1033 aa) |
| | TLR1 | Toll-like receptor. (786 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (613 aa) |
| | LOC100979649 | Ig-like domain-containing protein. (170 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | CALML5 | Calmodulin like 5. (146 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (339 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (347 aa) |
| | FCER1G | Uncharacterized protein. (112 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | LOC103785895 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa) |
| | MRC2 | Mannose receptor C type 2. (1479 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (266 aa) |
| | RFX5 | Regulatory factor X5. (618 aa) |
| | ENSPPAP00000008696 | Ig-like domain-containing protein. (147 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | LOC100993508 | Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa) |
| | ENSPPAP00000009755 | Ig-like domain-containing protein. (116 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | RFXAP | Regulatory factor X associated protein. (272 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (411 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (316 aa) |
| | LOC100986750 | Ig-like domain-containing protein. (287 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (331 aa) |
| | FCGR2A | Fc fragment of IgG receptor IIa. (316 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | RHOA | Uncharacterized protein. (206 aa) |
| | ENSPPAP00000016834 | Uncharacterized protein. (195 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | BCL2 | BCL2 apoptosis regulator. (193 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (260 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (489 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (578 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa) |
| | IFNA7 | Interferon alpha 7. (189 aa) |
| | IFNA21 | Interferon alpha 21. (189 aa) |
| | CALML4 | Calmodulin like 4. (196 aa) |
| | SPHK2 | Sphingosine kinase 2. (663 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa) |
| | FADD | Death domain-containing protein. (144 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (465 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (223 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TRADD | TNFRSF1A associated via death domain. (311 aa) |
| | IL6 | Uncharacterized protein. (198 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1131 aa) |
| | C3 | Complement C3. (1614 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (468 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | VDR | Vitamin D receptor. (477 aa) |
| | RAB5C | RAB5C, member RAS oncogene family. (249 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | MALT1 | MALT1 paracaspase. (786 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | CALM3 | Calmodulin 3; Belongs to the calmodulin family. (149 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | MHC-DMB | Ig-like domain-containing protein. (276 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | HLA-DQA2 | Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | LOC100984838 | Uncharacterized protein. (334 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (536 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | CREBBP | CREB binding protein. (2414 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | LOC100993847 | Ig-like domain-containing protein. (270 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (598 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1466 aa) |
| | BCL10 | CARD domain-containing protein. (316 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa) |
| | STAT1 | Signal transducer and activator of transcription. (759 aa) |
| | FCGR1A | Uncharacterized protein. (368 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (218 aa) |
| | LOC100990567 | C-type lectin domain-containing protein. (256 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (501 aa) |
| | LOC103785316 | Ig-like domain-containing protein. (221 aa) |
| | SRC | Tyrosine-protein kinase. (458 aa) |
| | CR1 | Uncharacterized protein. (582 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa) |
| | HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1. (261 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa) |
| | CD14 | CD14 molecule. (384 aa) |
| | HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (208 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (216 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | EEA1 | Early endosome antigen 1. (1411 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | CAMP | Cathelicidin antimicrobial peptide. (173 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (523 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | MRC1 | Mannose receptor C-type 1. (1456 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | IL23A | Interleukin 23 subunit alpha. (189 aa) |
| | LSP1 | Lymphocyte specific protein 1. (466 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa) |
| | CD209 | C-type lectin domain-containing protein. (312 aa) |
