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| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | LOC106634335 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | TICAM2 | TIR domain-containing adaptor molecule 2. (235 aa) |
| | RB1 | RB transcriptional corepressor 1. (911 aa) |
| | TIRAP | TIR domain-containing protein. (226 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IFNA17 | Interferon alpha 17. (189 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | IFNA6 | Interferon alpha 6. (189 aa) |
| | LOC100972005 | Uncharacterized protein. (198 aa) |
| | IFNA5 | Interferon alpha 5. (189 aa) |
| | IFNA10 | Interferon alpha 10. (189 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (478 aa) |
| | IFNA8 | Interferon alpha 8. (189 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (558 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | JAK1 | Tyrosine-protein kinase. (1153 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | CYCS | Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (395 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (339 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (963 aa) |
| | E2F1 | E2F transcription factor 1. (397 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | LOC103785895 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (540 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | PIK3R2 | Uncharacterized protein. (663 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (519 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | STAT6 | Signal transducer and activator of transcription. (852 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (316 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (975 aa) |
| | E2F3 | E2F transcription factor 3. (420 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | TLR3 | Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | ENSPPAP00000016834 | Uncharacterized protein. (195 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | BCL2 | BCL2 apoptosis regulator. (193 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | SLC10A1 | Solute carrier family 10 member 1. (349 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | IFNA7 | Interferon alpha 7. (189 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | IFNA21 | Interferon alpha 21. (189 aa) |
| | ATF6B | Activating transcription factor 6 beta. (708 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (418 aa) |
| | FADD | Death domain-containing protein. (144 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (648 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1147 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IL6 | Uncharacterized protein. (198 aa) |
| | IRF3 | Interferon regulatory factor 3. (452 aa) |
| | FAS | Fas cell surface death receptor. (335 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (766 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | EGR2 | Early growth response 2. (476 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (468 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1372 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (719 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | STAT4 | Signal transducer and activator of transcription. (742 aa) |
| | CREBBP | CREB binding protein. (2414 aa) |
| | MMP9 | Matrix metallopeptidase 9. (707 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1025 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (408 aa) |
| | TYK2 | Tyrosine-protein kinase. (1190 aa) |
| | ATF4 | Activating transcription factor 4. (340 aa) |
| | CASP12 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | STAT1 | Signal transducer and activator of transcription. (759 aa) |
| | STAT5B | Signal transducer and activator of transcription. (789 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (218 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (501 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa) |
| | SRC | Tyrosine-protein kinase. (458 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (912 aa) |
| | STAT3 | Signal transducer and activator of transcription. (781 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1064 aa) |
| | JAK3 | Tyrosine-protein kinase. (1090 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4369 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | NFKBIA | ANK_REP_REGION domain-containing protein. (456 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (736 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (523 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | YWHAQ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa) |
| | ELK1 | ETS transcription factor ELK1. (428 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
