STRINGSTRING
LOC100992309 LOC100992309 LOC106634335 LOC106634335 TRAF2 TRAF2 RB1 RB1 CCR5 CCR5 IFNA17 IFNA17 HLA-C HLA-C CALR CALR RPS6KB2 RPS6KB2 PPP3CB PPP3CB IFNA14 IFNA14 IFNA6 IFNA6 LOC100972005 LOC100972005 IFNA5 IFNA5 IFNA10 IFNA10 PIK3R3 PIK3R3 IL10RB IL10RB IFNA8 IFNA8 GNA13 GNA13 PRKACG PRKACG PRKACA PRKACA CCL4 CCL4 TBK1 TBK1 JAK1 JAK1 ADCY9 ADCY9 CRKL CRKL CYCS CYCS CXCR2 CXCR2 B2M B2M TNF TNF TNFRSF1A TNFRSF1A IKBKG IKBKG IFNA2 IFNA2 CREB3L4 CREB3L4 PLCB1 PLCB1 CALML5 CALML5 GNG2 GNG2 PLCB4 PLCB4 TAPBP TAPBP MAPK1 MAPK1 CCR1 CCR1 CALML3 CALML3 NFATC4 NFATC4 E2F1 E2F1 LOC100967628 LOC100967628 ADCY7 ADCY7 CCR3 CCR3 MYC MYC LOC103785895 LOC103785895 SOS1 SOS1 RHEB RHEB GNGT1 GNGT1 ATF2 ATF2 ITPR2 ITPR2 GNGT2 GNGT2 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA RPS6KB1 RPS6KB1 GNAQ GNAQ FASLG FASLG MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS CGAS CGAS TP53 TP53 BID BID IL6R IL6R MAP2K2 MAP2K2 TAP1 TAP1 ARHGEF11 ARHGEF11 PTGER4 PTGER4 BAK1 BAK1 CREB3L1 CREB3L1 GNB2 GNB2 MAPK12 MAPK12 CASP3 CASP3 CXCL8 CXCL8 CRK CRK GNAI1 GNAI1 ITGB3 ITGB3 CREB5 CREB5 NFATC1 NFATC1 E2F3 E2F3 ADCY6 ADCY6 TRAF5 TRAF5 RAC2 RAC2 PDIA3 PDIA3 HLA-G HLA-G STING1 STING1 RHOA RHOA ENSPPAP00000016834 ENSPPAP00000016834 PRKCA PRKCA SP1 SP1 PIK3CB PIK3CB GNAI2 GNAI2 LOC100974009 LOC100974009 PRKACB PRKACB PDGFRA PDGFRA NFKB1 NFKB1 GNG3 GNG3 RELA RELA IL10RA IL10RA RAC1 RAC1 GNAS GNAS IFNA7 IFNA7 BCAR1 BCAR1 CCL2 CCL2 GNAS-2 GNAS-2 IFNA21 IFNA21 CALML4 CALML4 ATF6B ATF6B LOC100989777 LOC100989777 Papa-A Papa-A GNG8 GNG8 GNG4 GNG4 PXN PXN TSC2 TSC2 TAP2 TAP2 IKBKB IKBKB CREB3 CREB3 ARHGEF12 ARHGEF12 CDK6 CDK6 PRKCB PRKCB CREB3L3 CREB3L3 FADD FADD ADCY2 ADCY2 RAF1 RAF1 TSC1 TSC1 CTNNB1 CTNNB1 AKT3 AKT3 TRADD TRADD IL6 IL6 IRF3 IRF3 FAS FAS ITGAV ITGAV MAPK11 MAPK11 ADCY5 ADCY5 MTOR MTOR CX3CL1 CX3CL1 EIF4EBP1 EIF4EBP1 GNG7 GNG7 CDK4 CDK4 MAP2K6 MAP2K6 ADCY8 ADCY8 CALM3 CALM3 CDKN1A CDKN1A MAPK13 MAPK13 CHUK CHUK NRAS NRAS GNB1 GNB1 PTK2B PTK2B PTGER2 PTGER2 HLA-E HLA-E GNAI3 GNAI3 ADCY3 ADCY3 ADCY4 ADCY4 GNA11 GNA11 ENSPPAP00000031810 ENSPPAP00000031810 ROCK2 ROCK2 IL1R1 IL1R1 ATF4 ATF4 ADCY1 ADCY1 GNB5 GNB5 AKAP13 AKAP13 ARHGEF1 ARHGEF1 BAX BAX PLCB2 PLCB2 CALML6 CALML6 IL1B IL1B AKT1 AKT1 ROCK1 ROCK1 PLCB3 PLCB3 ITPR3 ITPR3 SOS2 SOS2 SRC SRC ITPR1 ITPR1 NFATC2 NFATC2 STAT3 STAT3 CXCL12 CXCL12 NFATC3 NFATC3 GNG11 GNG11 GSK3B GSK3B E2F2 E2F2 CXCR4 CXCR4 GNAO1 GNAO1 NFKBIA NFKBIA MAPK14 MAPK14 PIK3R1 PIK3R1 PPP3CA PPP3CA CREB3L2 CREB3L2 GNB3 GNB3 PTGER3 PTGER3 ELK1 ELK1 PTGS2 PTGS2 CASP9 CASP9 GNB4 GNB4 CCL5 CCL5 EGFR EGFR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100992309C-C motif chemokine. (92 aa)
LOC106634335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
RB1RB transcriptional corepressor 1. (911 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
IFNA17Interferon alpha 17. (189 aa)
HLA-CMajor histocompatibility complex, class I, C; Belongs to the MHC class I family. (397 aa)
CALRCalreticulin. (417 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IFNA14Interferon alpha 14. (189 aa)
IFNA6Interferon alpha 6. (189 aa)
LOC100972005Uncharacterized protein. (198 aa)
IFNA5Interferon alpha 5. (189 aa)
IFNA10Interferon alpha 10. (189 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
IFNA8Interferon alpha 8. (189 aa)
GNA13Uncharacterized protein. (282 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CCL4C-C motif chemokine. (92 aa)
TBK1TANK binding kinase 1. (729 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
IFNA2Interferon alpha 2. (170 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALML5Calmodulin like 5. (146 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
TAPBPTAP binding protein. (466 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
E2F1E2F transcription factor 1. (397 aa)
LOC100967628C-C motif chemokine. (93 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
LOC103785895Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
RHEBUncharacterized protein. (173 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
GNAQG protein subunit alpha q. (313 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CGASCyclic GMP-AMP synthase. (509 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
IL6RInterleukin 6 receptor. (468 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1529 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GNB2G protein subunit beta 2. (340 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
GNAI1G protein subunit alpha i1. (323 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
E2F3E2F transcription factor 3. (420 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RAC2Rac family small GTPase 2. (192 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
HLA-GMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
STING1Stimulator of interferon protein. (379 aa)
RHOAUncharacterized protein. (206 aa)
ENSPPAP00000016834Uncharacterized protein. (195 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
SP1Sp1 transcription factor. (786 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LOC100974009Uncharacterized protein. (184 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
RAC1Uncharacterized protein. (224 aa)
GNASGNAS complex locus. (1043 aa)
IFNA7Interferon alpha 7. (189 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
CCL2C-C motif chemokine. (99 aa)
GNAS-2Uncharacterized protein. (245 aa)
IFNA21Interferon alpha 21. (189 aa)
CALML4Calmodulin like 4. (196 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
LOC100989777Uncharacterized protein. (191 aa)
Papa-AIGc1 domain-containing protein; Belongs to the MHC class I family. (406 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PXNUncharacterized protein. (1087 aa)
TSC2TSC complex subunit 2. (1807 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (724 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
FADDDeath domain-containing protein. (144 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
TSC1TSC complex subunit 1. (1164 aa)
CTNNB1Catenin beta 1. (781 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IL6Uncharacterized protein. (198 aa)
IRF3Interferon regulatory factor 3. (452 aa)
FASFas cell surface death receptor. (335 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNB1G protein subunit beta 1. (340 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (352 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNA11G protein subunit alpha 11. (319 aa)
ENSPPAP00000031810MHC_I-like_Ag-recog domain-containing protein. (194 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
ATF4Activating transcription factor 4. (340 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
GNB5G protein subunit beta 5. (395 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CALML6Calmodulin like 6. (181 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
SRCTyrosine-protein kinase. (458 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
E2F2E2F transcription factor 2. (437 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
GNAO1G protein subunit alpha o1. (354 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GNB3G protein subunit beta 3. (340 aa)
PTGER3Prostaglandin E receptor 3. (416 aa)
ELK1ETS transcription factor ELK1. (428 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
GNB4G protein subunit beta 4. (340 aa)
CCL5C-C motif chemokine. (91 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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