STRINGSTRING
BAD BAD LOC100975795 LOC100975795 TRAF2 TRAF2 LOC103783476 LOC103783476 RB1 RB1 CCR5 CCR5 DNAJA3 DNAJA3 HLA-C HLA-C POLB POLB CCR4 CCR4 PIK3R3 PIK3R3 H2BC5 H2BC5 IRF9 IRF9 PRKACG PRKACG PRKACA PRKACA H2BC10 H2BC10 JAK1 JAK1 H2BC1 H2BC1 TBPL1 TBPL1 IKBKG IKBKG IL6ST IL6ST H2BC18 H2BC18 CHEK1 CHEK1 CREB3L4 CREB3L4 LOC100987642 LOC100987642 UBR4 UBR4 HDAC8 HDAC8 H2BC9 H2BC9 H2BC11 H2BC11 LOC100981154 LOC100981154 H2BC13 H2BC13 MAPK1 MAPK1 LOC100985433 LOC100985433 H2BC14 H2BC14 H2BC3 H2BC3 H2BU1 H2BU1 CCR3 CCR3 SKP2 SKP2 ATF2 ATF2 CCND3 CCND3 VAC14 VAC14 TRAF3 TRAF3 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA SRF SRF CCNE2 CCNE2 HRAS HRAS TP53 TP53 CHD4 CHD4 SCRIB SCRIB PSMC1 PSMC1 BAK1 BAK1 CREB3L1 CREB3L1 EGR3 EGR3 CDKN1B CDKN1B CASP3 CASP3 GTF2H1 GTF2H1 IRF7 IRF7 YWHAE YWHAE CDC20 CDC20 LYN LYN NFKB2 NFKB2 CREB5 CREB5 GTF2E2 GTF2E2 GTF2E1 GTF2E1 TRAF5 TRAF5 CDC42 CDC42 LOC100969533 LOC100969533 HLA-G HLA-G TBP TBP RHOA RHOA PIK3CB PIK3CB PMAIP1 PMAIP1 PRKACB PRKACB HDAC5 HDAC5 NFKB1 NFKB1 HDAC1 HDAC1 RELA RELA EP300 EP300 HPN HPN RAC1 RAC1 ATP6V0D2 ATP6V0D2 TBPL2 TBPL2 HDAC2 HDAC2 GSN GSN ATF6B ATF6B HDAC6 HDAC6 LOC100989777 LOC100989777 LOC100985638 LOC100985638 Papa-A Papa-A DLG1 DLG1 PXN PXN CREB3 CREB3 CDK6 CDK6 VDAC3 VDAC3 CREB3L3 CREB3L3 EIF2AK2 EIF2AK2 YWHAH YWHAH DDB1 DDB1 LOC100982423 LOC100982423 TRADD TRADD IRF3 IRF3 HDAC4 HDAC4 C3 C3 EGR2 EGR2 MAPKAPK2 MAPKAPK2 YWHAB YWHAB CCND2 CCND2 RASA2 RASA2 GTF2H2 GTF2H2 CDK4 CDK4 USP7 USP7 CDKN2B CDKN2B RBL2 RBL2 LTBR LTBR ACTN1 ACTN1 GTF2A2 GTF2A2 RBPJL RBPJL HDAC3 HDAC3 HDAC11 HDAC11 CDKN1A CDKN1A SYK SYK UBE3A UBE3A GTF2A1 GTF2A1 NRAS NRAS HLA-E HLA-E CREBBP CREBBP LOC100978515 LOC100978515 YWHAZ YWHAZ ENSPPAP00000031810 ENSPPAP00000031810 ATF4 ATF4 CCNA2 CCNA2 MRPS18B MRPS18B STAT5B STAT5B GTF2H4 GTF2H4 BAX BAX GTF2H3 GTF2H3 CDK1 CDK1 KAT2B KAT2B ACTN4 ACTN4 SRC SRC STAT3 STAT3 SNW1 SNW1 JAK3 JAK3 PKM PKM HDAC10 HDAC10 KAT2A KAT2A TRAF1 TRAF1 NFKBIA NFKBIA DDX3X DDX3X HDAC7 HDAC7 LOC100988917 LOC100988917 RBPJ RBPJ PIK3R1 PIK3R1 STAT5A STAT5A CCNA1 CCNA1 CREB3L2 CREB3L2 RANBP1 RANBP1 YWHAQ YWHAQ MAD1L1 MAD1L1 SND1 SND1 HDAC9 HDAC9 SCIN SCIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (168 aa)
LOC100975795Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
LOC103783476Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RB1RB transcriptional corepressor 1. (911 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
HLA-CMajor histocompatibility complex, class I, C; Belongs to the MHC class I family. (397 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
IRF9Interferon regulatory factor 9. (392 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
CHEK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
LOC100987642Histone H2B; Belongs to the histone H2B family. (126 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5183 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (396 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100981154Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
LOC100985433Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
SKP2S-phase kinase associated protein 2. (437 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
SRFSerum response factor. (414 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CHD4Uncharacterized protein. (1914 aa)
SCRIBScribble planar cell polarity protein. (1656 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
EGR3Early growth response 3. (387 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
IRF7Interferon regulatory factor 7. (516 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CDC20Cell division cycle 20. (499 aa)
LYNTyrosine-protein kinase. (526 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
GTF2E1General transcription factor IIE subunit 1. (439 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
CDC42Uncharacterized protein. (191 aa)
LOC100969533Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
HLA-GMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
TBPTATA-box binding protein. (357 aa)
RHOAUncharacterized protein. (206 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PMAIP1Uncharacterized protein. (133 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
EP300E1A binding protein p300. (2411 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
RAC1Uncharacterized protein. (224 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
TBPL2TATA-box binding protein like 2. (375 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
GSNGelsolin. (784 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
HDAC6Histone deacetylase 6. (1215 aa)
LOC100989777Uncharacterized protein. (191 aa)
LOC100985638Histone H2B; Belongs to the histone H2B family. (167 aa)
Papa-AIGc1 domain-containing protein; Belongs to the MHC class I family. (406 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
PXNUncharacterized protein. (1087 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (418 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (243 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
LOC100982423Uncharacterized protein. (78 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IRF3Interferon regulatory factor 3. (452 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
C3Complement C3. (1614 aa)
EGR2Early growth response 2. (476 aa)
MAPKAPK2Protein kinase domain-containing protein. (365 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
RASA2RAS p21 protein activator 2. (929 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
LTBRLymphotoxin beta receptor. (435 aa)
ACTN1Actinin alpha 1. (914 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HDAC11Histone deacetylase 11. (320 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SYKTyrosine-protein kinase. (635 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (867 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (352 aa)
CREBBPCREB binding protein. (2414 aa)
LOC10097851514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
ENSPPAP00000031810MHC_I-like_Ag-recog domain-containing protein. (194 aa)
ATF4Activating transcription factor 4. (340 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
MRPS18BUncharacterized protein. (258 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
KAT2BLysine acetyltransferase 2B. (675 aa)
ACTN4Actinin alpha 4. (931 aa)
SRCTyrosine-protein kinase. (458 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
SNW1SNW domain containing 1. (571 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
HDAC10Histone deacetylase 10. (669 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
TRAF1TNF receptor-associated factor. (416 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1011 aa)
LOC100988917Histone domain-containing protein; Belongs to the histone H2B family. (153 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
RANBP1RAN binding protein 1. (278 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1058 aa)
SCINScinderin. (715 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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