STRINGSTRING
BAD BAD LOC106634335 LOC106634335 DDB2 DDB2 EGF EGF RALA RALA MAPK8 MAPK8 RPS6KB2 RPS6KB2 PIK3R3 PIK3R3 ARAF ARAF CYCS CYCS FOS FOS MAPK1 MAPK1 POLK POLK MYC MYC LOC103785895 LOC103785895 SOS1 SOS1 SMAD4 SMAD4 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA RPS6KB1 RPS6KB1 GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 MAP2K2 MAP2K2 RGL4 RGL4 BAK1 BAK1 CASP3 CASP3 TGFBR1 TGFBR1 TCF7L1 TCF7L1 RAC2 RAC2 MLH1 MLH1 AXIN1 AXIN1 RHOA RHOA TGFB1 TGFB1 TGFB3 TGFB3 PIK3CB PIK3CB PMAIP1 PMAIP1 BCL2 BCL2 APC APC RAC1 RAC1 LOC100989777 LOC100989777 SMAD3 SMAD3 MSH3 MSH3 AXIN2 AXIN2 MSH2 MSH2 TCF7 TCF7 RAF1 RAF1 SMAD2 SMAD2 CTNNB1 CTNNB1 AKT3 AKT3 RALB RALB BRAF BRAF MTOR MTOR DCC DCC CDKN1A CDKN1A APPL1 APPL1 NRAS NRAS MAPK9 MAPK9 BBC3 BBC3 BAX BAX AKT1 AKT1 BCL2L11 BCL2L11 SOS2 SOS2 GSK3B GSK3B RALGDS RALGDS MSH6 MSH6 PIK3R1 PIK3R1 GADD45A GADD45A AREG AREG EREG EREG MAPK10 MAPK10 LEF1 LEF1 TGFA TGFA CASP9 CASP9 GADD45B GADD45B EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (168 aa)
LOC106634335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RALARAS like proto-oncogene A. (206 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
POLKDNA polymerase kappa. (897 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
LOC103785895Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
RGL4Ras-GEF domain-containing protein. (588 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TCF7L1Transcription factor 7 like 1. (560 aa)
RAC2Rac family small GTPase 2. (192 aa)
MLH1MutL homolog 1. (756 aa)
AXIN1Axin 1. (862 aa)
RHOAUncharacterized protein. (206 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PMAIP1Uncharacterized protein. (133 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
RAC1Uncharacterized protein. (224 aa)
LOC100989777Uncharacterized protein. (191 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa)
AXIN2Axin 2. (843 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
TCF7HMG box domain-containing protein. (391 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RALBRAS like proto-oncogene B. (254 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
DCCDCC netrin 1 receptor. (1457 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BBC3Uncharacterized protein. (131 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
RALGDSUncharacterized protein. (913 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
AREGEGF-like domain-containing protein. (274 aa)
EREGEpiregulin. (169 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TGFATransforming growth factor alpha. (181 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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