STRINGSTRING
BCL2L1 BCL2L1 BAD BAD DDB2 DDB2 EGF EGF RB1 RB1 BRCA2 BRCA2 RALA RALA MAPK8 MAPK8 RPS6KB2 RPS6KB2 PIK3R3 PIK3R3 JAK1 JAK1 ARAF ARAF IKBKG IKBKG MAPK1 MAPK1 E2F1 E2F1 POLK POLK SMAD4 SMAD4 PIK3R2 PIK3R2 PIK3CA PIK3CA RPS6KB1 RPS6KB1 GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 ARHGEF6 ARHGEF6 TP53 TP53 RALBP1 RALBP1 RGL4 RGL4 BAK1 BAK1 TGFBR1 TGFBR1 E2F3 E2F3 RAC2 RAC2 CDC42 CDC42 TGFB1 TGFB1 TGFB3 TGFB3 PIK3CB PIK3CB NFKB1 NFKB1 RELA RELA RAC1 RAC1 LOC100989777 LOC100989777 SMAD3 SMAD3 IKBKB IKBKB CDK6 CDK6 RAF1 RAF1 SMAD2 SMAD2 AKT3 AKT3 RALB RALB BRAF BRAF MTOR MTOR PLD2 PLD2 CDK4 CDK4 CDKN1A CDKN1A CHUK CHUK MAPK9 MAPK9 STAT1 STAT1 BAX BAX AKT1 AKT1 STAT3 STAT3 E2F2 E2F2 ERBB2 ERBB2 RALGDS RALGDS PIK3R1 PIK3R1 GADD45A GADD45A MAPK10 MAPK10 TGFA TGFA CASP9 CASP9 GADD45B GADD45B EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1BCL2 like 1. (233 aa)
BADBCL2 associated agonist of cell death. (168 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RB1RB transcriptional corepressor 1. (911 aa)
BRCA2BRCA2 DNA repair associated. (3417 aa)
RALARAS like proto-oncogene A. (206 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
E2F1E2F transcription factor 1. (397 aa)
POLKDNA polymerase kappa. (897 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (783 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RALBP1RalA binding protein 1. (655 aa)
RGL4Ras-GEF domain-containing protein. (588 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
E2F3E2F transcription factor 3. (420 aa)
RAC2Rac family small GTPase 2. (192 aa)
CDC42Uncharacterized protein. (191 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RAC1Uncharacterized protein. (224 aa)
LOC100989777Uncharacterized protein. (191 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RALBRAS like proto-oncogene B. (254 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PLD2Phospholipase. (915 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
E2F2E2F transcription factor 2. (437 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
RALGDSUncharacterized protein. (913 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TGFATransforming growth factor alpha. (181 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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