STRINGSTRING
DDB2 DDB2 EGF EGF RB1 RB1 PIK3R3 PIK3R3 PDGFA PDGFA IGF1 IGF1 ARAF ARAF CALML5 CALML5 MAPK1 MAPK1 CALML3 CALML3 E2F1 E2F1 POLK POLK SOS1 SOS1 IGF1R IGF1R GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA SHC3 SHC3 GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 MAP2K2 MAP2K2 BAK1 BAK1 PDGFB PDGFB SHC1 SHC1 E2F3 E2F3 PRKCA PRKCA PIK3CB PIK3CB PDGFRA PDGFRA CALML4 CALML4 CAMK1 CAMK1 CDK6 CDK6 PRKCB PRKCB RAF1 RAF1 AKT3 AKT3 BRAF BRAF MTOR MTOR CDK4 CDK4 PDGFRB PDGFRB CALM3 CALM3 CDKN1A CDKN1A NRAS NRAS LOC100995377 LOC100995377 PLCG2 PLCG2 BAX BAX CALML6 CALML6 AKT1 AKT1 SOS2 SOS2 CAMK4 CAMK4 E2F2 E2F2 SHC4 SHC4 PIK3R1 PIK3R1 GADD45A GADD45A CAMK2A CAMK2A CAMK1G CAMK1G CAMK1D CAMK1D TGFA TGFA SHC2 SHC2 GADD45B GADD45B EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB2Damage specific DNA binding protein 2. (427 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RB1RB transcriptional corepressor 1. (911 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
IGF1IlGF domain-containing protein. (196 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CALML5Calmodulin like 5. (146 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
E2F1E2F transcription factor 1. (397 aa)
POLKDNA polymerase kappa. (897 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
SHC3SHC adaptor protein 3. (501 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SHC1SHC adaptor protein 1. (584 aa)
E2F3E2F transcription factor 3. (420 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CALML4Calmodulin like 4. (196 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100995377Uncharacterized protein. (557 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
CALML6Calmodulin like 6. (181 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
E2F2E2F transcription factor 2. (437 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (315 aa)
TGFATransforming growth factor alpha. (181 aa)
SHC2Uncharacterized protein. (539 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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