STRINGSTRING
FZD5 FZD5 DDB2 DDB2 WNT4 WNT4 WNT8A WNT8A WNT6 WNT6 WNT11 WNT11 WNT5B WNT5B DVL1 DVL1 WNT1 WNT1 POLK POLK WNT2B WNT2B WNT5A WNT5A WNT16 WNT16 FZD9 FZD9 GADD45G GADD45G BMP4 BMP4 TP53 TP53 BAK1 BAK1 WNT7A WNT7A WNT2 WNT2 FZD7 FZD7 BMP2 BMP2 TCF7L1 TCF7L1 PTCH2 PTCH2 AXIN1 AXIN1 DVL2 DVL2 SMO SMO FZD3 FZD3 APC APC HHIP HHIP WNT9B WNT9B SHH SHH WNT3A WNT3A AXIN2 AXIN2 TCF7 TCF7 FZD6 FZD6 CTNNB1 CTNNB1 WNT10B WNT10B WNT7B WNT7B GLI2 GLI2 WNT3 WNT3 CDKN1A CDKN1A KIF7 KIF7 WNT8B WNT8B FZD4 FZD4 BAX BAX WNT9A WNT9A GSK3B GSK3B WNT10A WNT10A DVL3 DVL3 PTCH1 PTCH1 GADD45A GADD45A LEF1 LEF1 GLI3 GLI3 GLI1 GLI1 GADD45B GADD45B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
DVL1Dishevelled segment polarity protein 1. (674 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
POLKDNA polymerase kappa. (897 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TCF7L1Transcription factor 7 like 1. (560 aa)
PTCH2Patched 2. (1203 aa)
AXIN1Axin 1. (862 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (771 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
HHIPHedgehog interacting protein. (700 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
AXIN2Axin 2. (843 aa)
TCF7HMG box domain-containing protein. (391 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
GLI2GLI family zinc finger 2. (1587 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1304 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (414 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
PTCH1Patched 1. (1446 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
GLI3GLI family zinc finger 3. (1580 aa)
GLI1GLI family zinc finger 1. (1106 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.