STRINGSTRING
BAD BAD DDB2 DDB2 EGF EGF RB1 RB1 FGF9 FGF9 PIK3R3 PIK3R3 PDGFA PDGFA IGF1 IGF1 ARAF ARAF MAPK1 MAPK1 FGF19 FGF19 E2F1 E2F1 POLK POLK IGF1R IGF1R PIK3R2 PIK3R2 PIK3CA PIK3CA GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 MAP2K2 MAP2K2 BAK1 BAK1 PDGFB PDGFB E2F3 E2F3 FGF20 FGF20 FGFR1 FGFR1 FGF5 FGF5 FGF22 FGF22 PIK3CB PIK3CB PDGFRA PDGFRA FGF21 FGF21 PDGFD PDGFD FGF16 FGF16 FGF23 FGF23 CDK6 CDK6 HGF HGF RAF1 RAF1 AKT3 AKT3 BRAF BRAF CDK4 CDK4 FGF7 FGF7 PDGFRB PDGFRB CDKN1A CDKN1A NRAS NRAS MET MET PDGFC PDGFC FGF10 FGF10 LOC100995377 LOC100995377 BAX BAX FGF8 FGF8 AKT1 AKT1 FGF6 FGF6 FGF1 FGF1 MITF MITF E2F2 E2F2 FGF2 FGF2 FGF3 FGF3 PIK3R1 PIK3R1 GADD45A GADD45A GADD45B GADD45B FGF18 FGF18 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BADBCL2 associated agonist of cell death. (168 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RB1RB transcriptional corepressor 1. (911 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
IGF1IlGF domain-containing protein. (196 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
E2F1E2F transcription factor 1. (397 aa)
POLKDNA polymerase kappa. (897 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
E2F3E2F transcription factor 3. (420 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FGF21Uncharacterized protein. (147 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC100995377Uncharacterized protein. (557 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
E2F2E2F transcription factor 2. (437 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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