STRINGSTRING
BCL2L1 BCL2L1 BAD BAD DDB2 DDB2 RB1 RB1 RUNX1 RUNX1 PIK3R3 PIK3R3 MECOM MECOM ARAF ARAF CRKL CRKL IKBKG IKBKG MAPK1 MAPK1 E2F1 E2F1 POLK POLK MYC MYC SOS1 SOS1 SMAD4 SMAD4 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA SHC3 SHC3 GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 BCR BCR MAP2K2 MAP2K2 BAK1 BAK1 CDKN1B CDKN1B GAB2 GAB2 CRK CRK SHC1 SHC1 TGFBR1 TGFBR1 E2F3 E2F3 TGFB1 TGFB1 TGFB3 TGFB3 PIK3CB PIK3CB NFKB1 NFKB1 HDAC1 HDAC1 RELA RELA CTBP1 CTBP1 CTBP2 CTBP2 HDAC2 HDAC2 SMAD3 SMAD3 IKBKB IKBKB CDK6 CDK6 RAF1 RAF1 AKT3 AKT3 PTPN11 PTPN11 BRAF BRAF ABL1 ABL1 CDK4 CDK4 CDKN1A CDKN1A CHUK CHUK NRAS NRAS CBL CBL STAT5B STAT5B BAX BAX AKT1 AKT1 SOS2 SOS2 E2F2 E2F2 NFKBIA NFKBIA SHC4 SHC4 PIK3R1 PIK3R1 STAT5A STAT5A GADD45A GADD45A SHC2 SHC2 GADD45B GADD45B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1BCL2 like 1. (233 aa)
BADBCL2 associated agonist of cell death. (168 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
RB1RB transcriptional corepressor 1. (911 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MECOMMDS1 and EVI1 complex locus. (1230 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
E2F1E2F transcription factor 1. (397 aa)
POLKDNA polymerase kappa. (897 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
SHC3SHC adaptor protein 3. (501 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
BCRUncharacterized protein. (1034 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SHC1SHC adaptor protein 1. (584 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
E2F3E2F transcription factor 3. (420 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
CTBP2C-terminal binding protein 2. (985 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CBLCbl proto-oncogene. (906 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
E2F2E2F transcription factor 2. (437 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SHC2Uncharacterized protein. (539 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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