STRINGSTRING
BCL2L1 BCL2L1 LOC106634335 LOC106634335 DDB2 DDB2 TRAF2 TRAF2 COL4A6 COL4A6 RB1 RB1 BIRC2 BIRC2 PIK3R3 PIK3R3 LAMA3 LAMA3 CYCS CYCS IKBKG IKBKG E2F1 E2F1 COL4A1 COL4A1 POLK POLK MYC MYC LOC103785895 LOC103785895 SKP2 SKP2 ITGA6 ITGA6 BIRC7 BIRC7 TRAF4 TRAF4 TRAF3 TRAF3 PIK3R2 PIK3R2 PIK3CA PIK3CA LAMB3 LAMB3 GADD45G GADD45G CCNE2 CCNE2 AKT2 AKT2 LAMB1 LAMB1 TP53 TP53 XIAP XIAP BAK1 BAK1 BIRC3 BIRC3 LAMA2 LAMA2 CDKN1B CDKN1B CASP3 CASP3 E2F3 E2F3 LAMA5 LAMA5 TRAF5 TRAF5 COL4A3 COL4A3 LAMA1 LAMA1 COL4A2 COL4A2 APAF1 APAF1 PIK3CB PIK3CB BCL2 BCL2 NFKB1 NFKB1 RXRG RXRG RELA RELA NOS2 NOS2 ITGA3 ITGA3 LAMC1 LAMC1 IKBKB IKBKB LAMC3 LAMC3 CDK6 CDK6 LAMB2 LAMB2 ZBTB17 ZBTB17 AKT3 AKT3 LAMC2 LAMC2 COL4A5 COL4A5 ITGAV ITGAV CDK4 CDK4 FHIT FHIT CDKN2B CDKN2B COL4A4 COL4A4 CDKN1A CDKN1A CHUK CHUK RARB RARB LAMB4 LAMB4 RXRB RXRB ITGB1 ITGB1 CKS1B CKS1B LAMA4 LAMA4 LOC100995377 LOC100995377 ITGA2B ITGA2B BAX BAX AKT1 AKT1 E2F2 E2F2 FN1 FN1 TRAF1 TRAF1 NFKBIA NFKBIA PIK3R1 PIK3R1 RXRA RXRA GADD45A GADD45A CKS2 CKS2 TRAF6 TRAF6 PTGS2 PTGS2 CASP9 CASP9 GADD45B GADD45B ITGA2 ITGA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1BCL2 like 1. (233 aa)
LOC106634335Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
RB1RB transcriptional corepressor 1. (911 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
E2F1E2F transcription factor 1. (397 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
POLKDNA polymerase kappa. (897 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
LOC103785895Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
SKP2S-phase kinase associated protein 2. (437 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1096 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
TRAF4TNF receptor-associated factor. (451 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
E2F3E2F transcription factor 3. (420 aa)
LAMA5Laminin subunit alpha 5. (3648 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
COL4A3Collagen type IV alpha 3 chain. (1641 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RXRGRetinoid X receptor gamma. (473 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
LAMC3Laminin subunit gamma 3. (1559 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
LAMB2Laminin subunit beta 2. (1780 aa)
ZBTB17Zinc finger and BTB domain containing 17. (807 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
COL4A5Collagen type IV alpha 5 chain. (1664 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FHITHIT domain-containing protein. (67 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
RARBRetinoic acid receptor beta. (448 aa)
LAMB4Laminin subunit beta 4. (1746 aa)
RXRBRetinoid X receptor beta. (537 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
LOC100995377Uncharacterized protein. (557 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
E2F2E2F transcription factor 2. (437 aa)
FN1Fibronectin 1. (2477 aa)
TRAF1TNF receptor-associated factor. (416 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
RXRARetinoid X receptor alpha. (472 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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